Search Result

Search Results for " microrna "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T61093	MicroRNA-21-IN-2		Others
	MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.		Others
T63879	microRNA-21-IN-1
	MicroRNA-21-IN-1 (compound 7A) is an effective inhibitor of microRNA with antiproliferative effects on Hela and HCT-116 cells, showing IC50 values of 5.5 μM and 2.8 μM, respectively. It also induces apoptosis in Hela cel...
T10831L	Cl-amidine hydrochloride		Apoptosis , PAD
	Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro ca...		Apoptosis , PAD
T11850	LIN28 inhibitor LI71
	LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.
T16538	PIN1 inhibitor API-1		Others
	PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, th...		Others
T11851	Lin28-let-7a antagonist 1		Others
	Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.		Others
T8333	Aurintricarboxylic acid	ATA,NSC-4056,NSC4056,NSC 4056	Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
	Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.		Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
T0717L	Enoxacin	NSC 629661,AT 2266,Pd107779,CI 919	DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic
	Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T0717	Enoxacin hydrate	CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate	DNA gyrase , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic
	Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T23777	BCI-137	BCI137	Others
	BCI-137 is an Argonaute 2 ligand. It acts by targeting the MicroRNA Binding Domain.		Others
T38680	RJW100		Others
	RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces r...		Others
T8902	DOTMA	Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium	Others
	DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) is a tetra-methylated DOTA analogue. DOTMA is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in lipos...		Others
T28045	MiR-21 Inhibitor-1
	miR-21 Inhibitor-1 is a microRNA-21 (miR-21) inhibitor.
T13085	Targaprimir-96		Others
	Targaprimir-96 is a potent microRNA-96 (miR-96) processing inhibitor.		Others
T16077	MIR96-IN-1		MALT
	MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.		MALT
T16882	SID 3712249	MiR-544 Inhibitor 1	Others
	SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).		Others
T13085L	Targaprimir-96 TFA (1655508-14-7 free base)	Targaprimir-96 TFA	Others
	Targaprimir-96 TFA is a potent microRNA-96 (miR-96) processing inhibitor.		Others
T39712	RGLS4326	RG4326,RGLS4326
	RGLS4326 (RG4326) is a short oligonucleotide inhibitor of microRNA-17 (miR-17), with a pioneering role in its class. This compound, with a research focus on autosomal dominant polycystic kidney disease (ADPKD), effective...
T74059	Targaprimir-96 TFA
	Targaprimir-96 TFA, a potent inhibitor of microRNA-96 (miR-96) processing, selectively reduces miR-96 production in cancer cells, thereby inducing apoptosis. This compound exhibits low nanomolar affinity binding to prima...
T73824	Thymidine 3',5'-diphosphate tetrasodium
	Thymidine 3',5'-diphosphate tetrasodium (Deoxythymidine 3′,5′-diphosphate tetrasodium) acts as a selective inhibitor targeting staphylococcal nuclease, tudor domain-containing 1 (SND1, a MicroRNA regulatory complex RISC ...

Compounds

Cl-amidine hydrochloride

T10831L

Synonym:

Target: Apoptosis, PAD

Lin28-let-7a antagonist 1

T11851

Synonym:

Target: Others

Aurintricarboxylic acid

T8333

Synonym: ATA,NSC-4056,NSC4056,NSC 4056

Target: Apoptosis, P2X Receptor, Influenza Virus, Topoisomerase

Enoxacin

T0717L

Synonym: NSC 629661,AT 2266,Pd107779,CI 919

Target: DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Enoxacin hydrate

T0717

Synonym: CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate

Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Linifanib

T2514

Synonym: ABT-869,RG3635,AL-39324

Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy

Synonym: Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium

Synonym: MiR-544 Inhibitor 1

Target: Others

Targaprimir-96 TFA (1655508-14-7 free base)

T13085L

Synonym: Targaprimir-96 TFA

Target: Others

RGLS4326

T39712

Synonym: RG4326,RGLS4326

Thymidine 3',5'-diphosphate tetrasodium

T73824

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T5S0246	Pseudoprotodioscin		Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.		Others , Fatty Acid Synthase
T1123	Camptothecin	NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT	Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
	Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
TN1068	Tricin		Others , CDK
	Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.		Others , CDK

Natural Products

Pseudoprotodioscin

T5S0246

Synonym:

Target: Others, Fatty Acid Synthase

Camptothecin

T1123

Synonym: NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT

Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02130	Argonaute-2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small...
TMPY-01186	Argonaute-2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small...
TMPJ-01155	PDCD4 Protein, Human, Recombinant (His)	Human	E. coli
	Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation...
TMPH-02189	TENT4B Protein, Human, Recombinant (His)	Human	E. coli
	Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active de...
TMPY-04084	ANGPTL1 Protein, Canine, Recombinant (hFc)	Canine	HEK293
	Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an im...
TMPY-03397	TPPP3 Protein, Human, Recombinant (His)	Human	E. coli
	TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons...
TMPH-01249	ADAR Protein, Human, Recombinant (GST)	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
TMPH-01248	ADAR Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...