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Cytoskeletal Signaling Microtubule Associated

Microtubule Associated

Microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of functions. These include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and mediating the interactions of microtubules with other proteins in the cell.
Cat No. product name
T0009 Flubendazole Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T0186 Docetaxel trihydrate Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
T0190 Vinorelbine Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor ...
T0320 ColchicineHOT Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
T0651 N-Phenylbenzylamine A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
T0838 Triclabendazole Triclabendazole has been used in trials studying Parasitic Disease.
T0938 Thiabendazole Thiabendazole is a benzimidazole derivative with anthelminthic property.
T0968 PaclitaxelHOT Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to ce...
T1034 DocetaxelHOT Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
T1121 Podophyllotoxin Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
T1152 Albendazole Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T1155 Mebendazole Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
T1270 Vincristine sulfateHOT Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic sp...
T1382 Griseofulvin Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
T1753 D64131 D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T1758 ABT-751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T1820 CK-636 CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM)...
T1910 Ansamitocin P-3 Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
T2060 LR-510444 ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter...
T2090 Lexibulin Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and le...
T2220 2-Methoxyestradiol 2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
T2502 INH1 INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T2511 Plinabulin Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bin...
T2543 Cabazitaxel Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of doce...
T2802 Nocodazole Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM)...
T3652 KRIBB11 KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T4029 BTB-1 BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T4077 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation.
T4125 HSF1A HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T4232 VCMMAE VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
T6075 Epothilone B Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabil...
T6180 INH6 INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
T6209 CW069 CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T6212 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T6213 Vinorelbine Tartrate Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6272 Fosbretabulin Disodium Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-...
T6372 Albendazole Oxide Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
T6490 Epothilone A Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T6721 Vinblastine Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T6864 Ixabepilone Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arre...
T6888 Methylene Blue Methylene Blue(IC50 of 1.9μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T6897 Monomethyl auristatin E Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug ...
T7003 TRx0237 mesylate TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
T4677 MMAD MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
T5170 KHS101 hydrochloride KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T5699 SSE15206 SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spind...
T6071 Parbendazole Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatmen...
TQ0141 Taltobulin Taltobulin (HTI-286) is a potent tubulin inhibitor.
TQ0202 Epothilone D Epothilone D (KOS 862) is an effective microtubule stabilizer.
Flubendazole
T0009CAS 31430-15-6
Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
Docetaxel trihydrate
T0186CAS 148408-66-6
Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
Vinorelbine
T0190CAS 71486-22-1
Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor ...
Colchicine HOT
T0320CAS 64-86-8
Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
N-Phenylbenzylamine
T0651CAS 103-32-2
A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
Oxfendazole
T0714CAS 53716-50-0
Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
Triclabendazole
T0838CAS 68786-66-3
Triclabendazole has been used in trials studying Parasitic Disease.
Thiabendazole
T0938CAS 148-79-8
Thiabendazole is a benzimidazole derivative with anthelminthic property.
Paclitaxel HOT
T0968CAS 33069-62-4
Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to ce...
Docetaxel HOT
T1034CAS 114977-28-5
Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
Podophyllotoxin
T1121CAS 518-28-5
Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
Albendazole
T1152CAS 54965-21-8
Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
Mebendazole
T1155CAS 31431-39-7
Mebendazole is a hedgehog inhibitor, used as an antihelminthic.
Vincristine sulfate HOT
T1270CAS 2068-78-2
Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic sp...
Griseofulvin
T1382CAS 126-07-8
Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
D64131
T1753CAS 74588-78-6
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
ABT-751
T1758CAS 141430-65-1
ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
CK-636
T1820CAS 442632-72-6
CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM)...
Ansamitocin P-3
T1910CAS 66547-09-9
Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
LR-510444
T2060CAS 1233948-35-0
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter...
Lexibulin
T2090CAS 917111-44-5
Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and le...
2-Methoxyestradiol
T2220CAS 362-07-2
2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
INH1
T2502CAS 313553-47-8
INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
Plinabulin
T2511CAS 714272-27-2
Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bin...
Cabazitaxel
T2543CAS 183133-96-2
Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of doce...
Nocodazole
T2802CAS 31430-18-9
Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM)...
KRIBB11
T3652CAS 342639-96-7
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
BTB-1
T4029CAS 86030-08-2
BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
PE859
T4077CAS 1402727-29-0
PE859 is a potent inhibitor of both tau and Aβ aggregation.
HSF1A
T4125CAS 1196723-93-9
HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
VCMMAE
T4232CAS 646502-53-6
VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
Epothilone B
T6075CAS 152044-54-7
Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabil...
INH6
T6180CAS 1001753-24-7
INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
CW069
T6209CAS 1594094-64-0
CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
Combretastatin A4
T6212CAS 117048-59-6
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
Vinorelbine Tartrate
T6213CAS 125317-39-7
Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
Fosbretabulin Disodium
T6272CAS 168555-66-6
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-...
Albendazole Oxide
T6372CAS 54029-12-8
Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
Epothilone A
T6490CAS 152044-53-6
Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
Vinblastine
T6721CAS 865-21-4
Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
Ixabepilone
T6864CAS 219989-84-1
Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arre...
Methylene Blue
T6888CAS 61-73-4
Methylene Blue(IC50 of 1.9μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
Monomethyl auristatin E
T6897CAS 474645-27-7
Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug ...
TRx0237 mesylate
T7003CAS 1236208-20-0
TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
MMAD
T4677CAS 203849-91-6
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
KHS101 hydrochloride
T5170CAS 1784282-12-7
KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
SSE15206
T5699CAS 1370046-40-4
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spind...
Parbendazole
T6071CAS 14255-87-9
Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatmen...
Taltobulin
TQ0141CAS 228266-40-8
Taltobulin (HTI-286) is a potent tubulin inhibitor.
Epothilone D
TQ0202CAS 189453-10-9
Epothilone D (KOS 862) is an effective microtubule stabilizer.