Microtubule Associated

Microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of functions. These include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and mediating the interactions of microtubules with other proteins in the cell.

Cat No.	product name
T0009	Flubendazole	Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T0186	Docetaxel trihydrate	Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
T0190	Vinorelbine	Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor ...
T0320	ColchicineHOT	Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
T0651	N-Phenylbenzylamine	A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
T0714	Oxfendazole	Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
T0838	Triclabendazole	Triclabendazole has been used in trials studying Parasitic Disease.
T0938	Thiabendazole	Thiabendazole is a benzimidazole derivative with anthelminthic property.
T0968	PaclitaxelHOT	Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to ce...
T1034	DocetaxelHOT	Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
T1121	Podophyllotoxin	Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
T1152	Albendazole	Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T1155	Mebendazole	Mebendazole is a hedgehog inhibitor， used as an antihelminthic.
T1270	Vincristine sulfateHOT	Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic sp...
T1382	Griseofulvin	Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
T1753	D64131	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T1758	ABT-751	ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T1820	CK-636	CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM)...
T1910	Ansamitocin P-3	Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
T2060	LR-510444	ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter...
T2090	Lexibulin	Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and le...
T2220	2-Methoxyestradiol	2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
T2502	INH1	INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T2511	Plinabulin	Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bin...
T2543	Cabazitaxel	Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of doce...
T2802	Nocodazole	Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM)...
T3652	KRIBB11	KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T4029	BTB-1	BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T4077	PE859	PE859 is a potent inhibitor of both tau and Aβ aggregation.
T4125	HSF1A	HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T4232	VCMMAE	VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
T6075	Epothilone B	Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabil...
T6180	INH6	INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
T6209	CW069	CW069( IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T6212	Combretastatin A4	Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T6213	Vinorelbine Tartrate	Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6272	Fosbretabulin Disodium	Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-...
T6372	Albendazole Oxide	Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
T6490	Epothilone A	Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T6721	Vinblastine	Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T6864	Ixabepilone	Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arre...
T6888	Methylene Blue	Methylene Blue(IC50 of 1.9μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T6897	Monomethyl auristatin E	Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug ...
T7003	TRx0237 mesylate	TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
T4677	MMAD	MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
T5170	KHS101 hydrochloride	KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T5699	SSE15206	SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spind...
T6071	Parbendazole	Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatmen...
TQ0141	Taltobulin	Taltobulin (HTI-286) is a potent tubulin inhibitor.
TQ0202	Epothilone D	Epothilone D (KOS 862) is an effective microtubule stabilizer.