Microtubule Associated

Microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of functions. These include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and mediating the interactions of microtubules with other proteins in the cell.

Cat No.	product name
T0009	Flubendazole	Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T0186	Docetaxel trihydrate	Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
T0190	Vinorelbine	Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor ...
T0320	ColchicineHOT	Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin.
T0651	N-Phenylbenzylamine	A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization
T0714	Oxfendazole	Oxfendazole, a broad spectrum benzimidazole anthelmintic,protects livestock against roundworm, strongyles and pinworms.
T0838	Triclabendazole	Triclabendazole has been used in trials studying Parasitic Disease.
T0938	Thiabendazole	Thiabendazole is a benzimidazole derivative with anthelminthic property.
T0968	PaclitaxelHOT	Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to ce...
T1034	DocetaxelHOT	Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).
T10428	AZ82	AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
T1121	Podophyllotoxin	Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
T1152	Albendazole	Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T1155	Mebendazole	Mebendazole is a hedgehog inhibitor， used as an antihelminthic.
T12052	Mivobulin	Mivobulin is an inhibitor of tubulin .
T1270	Vincristine sulfateHOT	Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic sp...
T12805	S-methyl DM1	S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.
T12823	S516	S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
T13224	Tubulin inhibitor 6	Tubulin inhibitor 6 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.
T13225	Tubulin inhibitor 7	Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines(tubulin polymerization(IC50 of 0.52 μM), K562 cell growth(I...
T13226	Tubulin inhibitor 8	Tubulin inhibitor 8 is an inhibitor of tubulin and multiple cancer cell lines(tubulin polymerization with an IC50 of 0.73 μM, K562 cell growth with an IC50 of ...
T13227	Tubulin inhibitor 1	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization,with potent anti-tumor activity, induces cellular apoptosis casues and cellular ...
T13228	Tubulysin D	Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis,and displays potent antitumor activity.
T13298	Verubulin hydrochloride	Verubulin hydrochloride is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent ant...
T13807	OSIP-486823	OSIP-486823 is a microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.
T1382	Griseofulvin	Griseofulvin is an antifungal agent used in the treatment of TINEA infections.
T13901	SS28	SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.
T14349	Auristatin F	Auristatin F is a potent cytotoxin. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (A...
T14350	Soblidotin	Soblidotin (Auristatin PE) is an inhibitor of tubulin polymerization. It also is a novel synthetic Dolastatin 10 derivative.
T15012	Crolibulin	Crolibulin is an inhibitor of small molecule tubulin polymerization.
T15576	Indibulin	Indibulin decreases inter-kinetochoric tension, activates mitotic checkpoint proteins Mad2 and BubR1, produces aberrant spindles, and induces mitotic arrest an...
T16386	Ombrabulin hydrochloride	Ombrabulin hydrochloride is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of...
T16387	Ombrabulin	Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial c...
T16543	Pironetin	Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an...
T16997	Tasidotin hydrochloride	Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and m...
T17228	VERU-111	VERU-111 is an effective and orally bioavailable α and β tubulin inhibitor (average IC50: 5.2 nM) against panels of melanoma and prostate cancer cell lines. V...
T17229	Verubulin	Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities.
T1753	D64131	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T1758	ABT-751	ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T1820	CK-636	CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM)...
T1910	Ansamitocin P-3	Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity.
T2060	LR-510444	ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter...
T2090	Lexibulin	Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and le...
T2220	2-Methoxyestradiol	2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
T2502	INH1	INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.
T2511	Plinabulin	Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bin...
T2543	Cabazitaxel	Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of doce...
T2802	Nocodazole	Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM)...
T2937	4'-Demethylepipodophyllotoxin	4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
T3652	KRIBB11	KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T4029	BTB-1	BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T4077	PE859	PE859 is a potent inhibitor of both tau and Aβ aggregation.
T4125	HSF1A	HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T4232	VCMMAE	VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
T4677	MMAD	MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
T5170	KHS101 hydrochloride	KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.
T5699	SSE15206	SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spind...
T6071	Parbendazole	Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatmen...
T6075	Epothilone B	Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabil...
T6180	INH6	INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
T6209	CW069	CW069( IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T6212	Combretastatin A4	Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T6213	Vinorelbine Tartrate	Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6272	Fosbretabulin Disodium	Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-...
T6372	Albendazole Oxide	Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
T6490	Epothilone A	Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T6721	Vinblastine	Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.
T6864	Ixabepilone	Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arre...
T6888	Methylene Blue	Methylene Blue(IC50 of 1.9μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T6897	Monomethyl auristatin E	Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug ...
T7003	TRx0237 mesylate	TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
T8216	T-1101 tosylate	T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.
T8492	BO-264	BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).
TN1087	Deoxypodophyllotoxin	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
TQ0112	Tubulysin A	Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, antic...
TQ0141	Taltobulin	Taltobulin (HTI-286) is a potent tubulin inhibitor.
TQ0202	Epothilone D	Epothilone D (KOS 862) is an effective microtubule stabilizer.