T0006 |
Methylene Blue trihydrate |
Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blu...
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T0009 |
Flubendazole |
Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans. |
T0186 |
Docetaxel trihydrate |
Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
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T0190 |
Vinorelbine |
Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor ...
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T0320 |
ColchicineHOT |
Colchicine is a tubulin inhibitor (IC50: 3 nM) and blocks polymerization of microtubules by binding to tubulin. |
T0651 |
N-Phenylbenzylamine |
A series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization |
T0714 |
Oxfendazole |
Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms. |
T0838 |
Triclabendazole |
Triclabendazole has been used in trials studying Parasitic Disease. |
T0938 |
Thiabendazole |
Thiabendazole is a benzimidazole derivative with anthelminthic property. |
T0968 |
PaclitaxelHOT |
Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree. It stabilizes microtubules in their polymerized form leading to cell death. |
T1034 |
DocetaxelHOT |
Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM). |
T10428 |
AZ82 |
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1). |
T1121 |
Podophyllotoxin |
Podophyllotoxin is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally,...
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T1152 |
Albendazole |
Albendazole is used as a drug indicated for the treatment of a variety of worm infestations. |
T1155 |
Mebendazole |
Mebendazole is a hedgehog inhibitor, used as an antihelminthic. |
T11917 |
Lys-SMCC-DM1 |
DM1 is a tubulin inhibitor. Lys-SMCC-DM1 is the active metabolite of DM1. |
T12052 |
Mivobulin |
Mivobulin is an inhibitor of tubulin . |
T1270 |
Vincristine sulfateHOT |
Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic sp...
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T12805 |
S-methyl DM1 |
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization. |
T12823 |
S516 |
S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity. |
T13224 |
Tubulin inhibitor 6 |
Tubulin inhibitor 6 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines. |
T13225 |
Tubulin inhibitor 7 |
Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (...
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T13226 |
Tubulin inhibitor 8 |
Tubulin inhibitor 8 is an inhibitor of tubulin and multiple cancer cell lines (tubulin polymerization with an IC50 of 0.73 μM, K562 cell growth with an IC50 of...
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T13227 |
Tubulin inhibitor 1 |
Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular...
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T13228 |
Tubulysin D |
Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity. |
T13298 |
Verubulin hydrochloride |
Verubulin hydrochloride is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent ant...
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T13807 |
OSIP-486823 |
OSIP-486823 is a microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules. |
T1382 |
Griseofulvin |
Griseofulvin is an antifungal agent used in the treatment of TINEA infections. |
T13901 |
SS28 |
SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. |
T14349 |
Auristatin F |
Auristatin F is a potent cytotoxin. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (A...
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T14350 |
Soblidotin |
Soblidotin (Auristatin PE) is an inhibitor of tubulin polymerization. It also is a novel synthetic Dolastatin 10 derivative. |
T15012 |
Crolibulin |
Crolibulin is an inhibitor of small molecule tubulin polymerization. |
T15576 |
Indibulin |
Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly,...
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T16031 |
McMMAF |
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC lin...
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T16031 |
McMMAF |
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC lin...
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T16386 |
Ombrabulin hydrochloride |
Ombrabulin hydrochloride is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of...
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T16387 |
Ombrabulin |
Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial c...
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T16543 |
Pironetin |
Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an...
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T16997 |
Tasidotin hydrochloride |
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and m...
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T17228 |
VERU-111 |
VERU-111 is an effective and orally bioavailable α and β tubulin inhibitor (average IC50: 5.2 nM) against panels of melanoma and prostate cancer cell lines. V...
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T17229 |
Verubulin |
Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities. |
T1753 |
D64131 |
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. |
T1758 |
ABT751 |
ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. |
T1820 |
CK636 |
CK-636, an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM)...
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T1910 |
Ansamitocin P-3 |
Ansamitocin P-3 is an antibody-drug conjugate cytotoxin with antitumor activity. |
T1992 |
Mertansine |
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reac...
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T1992 |
Mertansine |
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reac...
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T2060 |
LR510444 |
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter...
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T2090 |
Lexibulin |
Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and le...
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T2217 |
Cephalomannine |
Cephalomannine is a taxol derivative obtained from Taxus yunnanensis with antitumor activity. |
T2220 |
2-Methoxyestradiol |
2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing e...
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T2502 |
INH1 |
INH1 is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction. |
T2511 |
Plinabulin |
Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and bin...
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T2543 |
Cabazitaxel |
Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of doce...
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T2773 |
Vindoline |
Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly. |
T2802 |
Nocodazole |
Nocodazole is a synthetic inhibitor of microtubule polymerization, also inhibits Abl (IC50: 0.21 μM), Abl(E255K, IC50: 0.53 μM) and Abl(T315I, IC50: 0.64 μM)...
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T2937 |
4'-Demethylepipodophyllotoxin |
4'-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly. |
T3652 |
KRIBB11 |
KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor. |
T4029 |
BTB1 |
BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A. |
T4077 |
PE859 |
PE859 is a potent inhibitor of both tau and Aβ aggregation. |
T4125 |
HSF1A |
HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis. |
T4232 |
VCMMAE |
VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity. |
T4451 |
Estramustine phosphate sodium |
Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. |
T4677 |
MMAD |
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs). |
T5170 |
KHS101 hydrochloride |
KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype. |
T5699 |
SSE15206 |
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spind...
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T6071 |
Parbendazole |
Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatm...
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T6075 |
Epothilone B |
Epothilone B is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabil...
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T6180 |
INH6 |
INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment. |
T6209 |
CW069 |
CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP. |
T6212 |
Combretastatin A4 |
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). |
T6213 |
Vinorelbine Tartrate |
Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition. |
T6272 |
Fosbretabulin Disodium |
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-...
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T6372 |
Albendazole Oxide |
Albendazole Sulfoxide (Albendazole EP Impurity B) is a metabolite of Albendazole, an anthelmintic. |
T6490 |
Epothilone A |
Epothilone A is a microtubule-stabilizing agent with EC0.01 of 2 μM. |
T6691 |
TAI1 |
TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. |
T6721 |
Vinblastine |
Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer. |
T6722 |
Vinflunine Tartrate |
Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. |
T6864 |
Ixabepilone |
Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arre...
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T6888 |
Methylene Blue |
Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy. |
T6897 |
Monomethyl auristatin E |
Monomethyl auristatin E (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug ...
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T7003 |
TRx0237 mesylate |
TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
T8216 |
T-1101 tosylate |
T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity. |
T8492 |
BO-264 |
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM). |
TN1087 |
Deoxypodophyllotoxin |
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflamma...
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TQ0112 |
Tubulysin A |
Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, antic...
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TQ0141 |
Taltobulin |
Taltobulin (HTI-286) is a potent tubulin inhibitor. |
TQ0202 |
Epothilone D |
Epothilone D (KOS 862) is an effective microtubule stabilizer. |