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Search Results for " mitochondrial metabolism "

Targets

59

Compounds

21

Natural Products

30

Recombinant Proteins

3

Libraries

Cat No. Product Name Synonyms Targets
T9372 D-Histidine Mitochondrial Metabolism
D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.
T9777 THP104c Mitochondrial Metabolism
THP104c is an inhibitor of mitochondrial fission.
T15373 Gboxin ATPase , Mitochondrial Metabolism
Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
T12408 Perhexiline maleate Others , Mitochondrial Metabolism
Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively.
T1768 7ACC2 Mitochondrial Metabolism , Monocarboxylate transporter
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
T9232 Mitochondrial fusion promoter M1 Mitochondrial Metabolism
Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates ...
T9031 MCU-i4 Others , Mitochondrial Metabolism
MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
T15241 ER-000444793 Others , Mitochondrial Metabolism
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
T14497 BAM 15 OXPHOS , Mitochondrial Metabolism
BAM 15 is an uncoupler of mitochondrial protonophore.
T10706 CCI-006 Mitochondrial Metabolism
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein r...
T19428 Mito-TEMPO Reactive Oxygen Species , Mitochondrial Metabolism
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties.
T9169 MPP+ iodide Mitochondrial Metabolism , Autophagy
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex...
T8732 CTPI-2 Others , Mitochondrial Metabolism
CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha...
T4639 Azemiglitazone MSDC 0602 Mitochondrial Metabolism , mTOR
Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.
T6157 Devimistat CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid Apoptosis , Dehydrogenase , Mitochondrial Metabolism
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent...
T2498 Adjudin AF-2364 Chloride channel , Mitochondrial Metabolism
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T5827 BI-6C9 Apoptosis , Others , Mitochondrial Metabolism
BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.
T16342 KL1333 NQO1 activator 1 NADPH , Mitochondrial Metabolism
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ...
T0239 Lonidamine AF1890,DICA,Diclondazolic Acid Apoptosis , Hexokinase , Mitochondrial Metabolism
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
T8500 VLX600 OXPHOS , Mitochondrial Metabolism , Autophagy
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.
T6834 FCCP Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone ATPase , Mitochondrial Metabolism
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone), a potent uncoupler of oxidative phosphorylation in mitochondria, transport protons across cell membranes leading to disrupts ATP synthesis.
T5337 IACS-010759 IACS-10759,IACS 10759,IACS10759 Apoptosis , Others , Mitochondrial Metabolism
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.
T8308 NL-1 Mitochondrial Metabolism , Autophagy
NL-1 is a mitoNEET inhibitor with antileukemic effect.
T8366 Mitochonic acid 5 MA-5 Mitochondrial Metabolism
Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of f...
T4441 UK-5099 UK 5099,PF-1005023,UK5099 Others , Mitochondrial Metabolism
UK-5099 (PF-1005023) is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM) [1].
T2607 MSDC 0160 CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 Others , IGF-1R , Mitochondrial Metabolism
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
T1640 Ciprofloxacin Ciproxan,Ciprobay,Bay o 9867,Bay-09867 Topoisomerase , Antibacterial , Antibiotic
Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.
T9235 GW604714X 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- Mitochondrial Metabolism
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate
T9211 Mito-LND Mito-Loidamine OXPHOS , Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T0412 Idebenone CV-2619 Apoptosis , Antioxidant , Mitochondrial Metabolism
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).
T7629 Olesoxime NSC 21311,TRO 19622 Mitochondrial Metabolism
Olesoxime (TRO 19622) (TRO19622), A Mitochondrial-Targeted Neuroprotective Compound,is an experimental neuroprotective drug.
T1634 Glibenclamide Glyburide Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T0250 Ciprofloxacin monohydrochloride Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T5363 Tempo 2,2,6,6-Tetramethylpiperidinooxy Free radical scavengers , Reactive Oxygen Species , DNA/RNA Synthesis , Mitochondrial Metabolism
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.
T7486 Imeglimin hydrochloride EMD 387008 hydrochloride Reactive Oxygen Species , Mitochondrial Metabolism
Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
T22381 Antimalarial agent 14 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone Others
Antimalarial agent 14 (NSC-102533) is a bioactive chemical.
T7487 Speract Others , Mitochondrial Metabolism
Speract is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
T8841 IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) Others , DNA/RNA Synthesis , Mitochondrial Metabolism
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
T13748 L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium Histone Demethylase , Mitochondrial Metabolism
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ...
T7081 CCCP Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone Apoptosis , IκB/IKK , COX , Mitochondrial Metabolism , STING , IFNAR , Antibacterial
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ...
T7487L Speract TFA(76901-59-2(free base)) Others
Speract TFA is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
T9768L Ninerafaxstat trihydrochloride Ninerafaxstat trihydrochloride(2254741-41-6 Free base) Others
Ninerafaxstat trihydrochloride shifts cellular metabolism to glucose oxidation from fatty acid oxidation. Ninerafaxstat trihydrochloride improves overall mitochondrial respiration and reduces fatty acid oxidation, thereb...
T38715 MSDC-0602K MSDC-0602K,Azemiglitazone potassium PPAR
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (...
T10035 10,12-Tricosadiynoic acid TDA,TCDA Acyltransferase
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me...
T27417L Glutathione arsenoxide hydrochloride GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base) Apoptosis , AChR
Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) is a potentially active anti-cancer molecule and inhibitor of tumour metabolism. glutathione arsenoxide hydrochloride ta...
T33511 Ms2i6A ms2i6-2-6,ms2i6 2 6
ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.
T70032 NCI-006
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both m...
T9768 Ninerafaxstat Others
Ninerafaxstat hifts cellular metabolism from fatty acid oxidation to glucose oxidation.Ninerafaxstat decreases fatty acid oxidation and improve overall mitochondrial respiration.Ninerafaxstat inhibit the growth and proli...
T79226 AMPK activator 11 Mitochondrial Metabolism
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative...
T79285 TRAP1-IN-1 HSP
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and p...

Compounds

D-Histidine
T9372
Synonym:
Target: Mitochondrial Metabolism
THP104c
T9777
Synonym:
Target: Mitochondrial Metabolism
Gboxin
T15373
Synonym:
Target: ATPase, Mitochondrial Metabolism
Perhexiline maleate
T12408
Synonym:
Target: Others, Mitochondrial Metabolism
7ACC2
T1768
Synonym:
Target: Mitochondrial Metabolism, Monocarboxylate transporter
Mitochondrial fusion promoter M1
T9232
Synonym:
Target: Mitochondrial Metabolism
MCU-i4
T9031
Synonym:
Target: Others, Mitochondrial Metabolism
ER-000444793
T15241
Synonym:
Target: Others, Mitochondrial Metabolism
BAM 15
T14497
Synonym:
Target: OXPHOS, Mitochondrial Metabolism
CCI-006
T10706
Synonym:
Target: Mitochondrial Metabolism
Mito-TEMPO
T19428
Synonym:
Target: Reactive Oxygen Species, Mitochondrial Metabolism
MPP+ iodide
T9169
Synonym:
Target: Mitochondrial Metabolism, Autophagy
CTPI-2
T8732
Synonym:
Target: Others, Mitochondrial Metabolism
Azemiglitazone
T4639
Synonym: MSDC 0602
Target: Mitochondrial Metabolism, mTOR
Devimistat
T6157
Synonym: CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid
Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism
Adjudin
T2498
Synonym: AF-2364
Target: Chloride channel, Mitochondrial Metabolism
BI-6C9
T5827
Synonym:
Target: Apoptosis, Others, Mitochondrial Metabolism
KL1333
T16342
Synonym: NQO1 activator 1
Target: NADPH, Mitochondrial Metabolism
Lonidamine
T0239
Synonym: AF1890,DICA,Diclondazolic Acid
Target: Apoptosis, Hexokinase, Mitochondrial Metabolism
VLX600
T8500
Synonym:
Target: OXPHOS, Mitochondrial Metabolism, Autophagy
FCCP
T6834
Synonym: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone
Target: ATPase, Mitochondrial Metabolism
IACS-010759
T5337
Synonym: IACS-10759,IACS 10759,IACS10759
Target: Apoptosis, Others, Mitochondrial Metabolism
NL-1
T8308
Synonym:
Target: Mitochondrial Metabolism, Autophagy
Mitochonic acid 5
T8366
Synonym: MA-5
Target: Mitochondrial Metabolism
UK-5099
T4441
Synonym: UK 5099,PF-1005023,UK5099
Target: Others, Mitochondrial Metabolism
MSDC 0160
T2607
Synonym: CAY10415,Mitoglitazone,MSDC0160,MSDC-0160
Target: Others, IGF-1R, Mitochondrial Metabolism
Ciprofloxacin
T1640
Synonym: Ciproxan,Ciprobay,Bay o 9867,Bay-09867
Target: Topoisomerase, Antibacterial, Antibiotic
GW604714X
T9235
Synonym: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-
Target: Mitochondrial Metabolism
Mito-LND
T9211
Synonym: Mito-Loidamine
Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy
Idebenone
T0412
Synonym: CV-2619
Target: Apoptosis, Antioxidant, Mitochondrial Metabolism
Olesoxime
T7629
Synonym: NSC 21311,TRO 19622
Target: Mitochondrial Metabolism
Glibenclamide
T1634
Synonym: Glyburide
Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy
Ciprofloxacin monohydrochloride
T0250
Synonym: Bay-09867 (hydrochloride),Ciprofloxacin HCl,Ciprofloxacin hydrochloride
Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic
Tempo
T5363
Synonym: 2,2,6,6-Tetramethylpiperidinooxy
Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism
Imeglimin hydrochloride
T7486
Synonym: EMD 387008 hydrochloride
Target: Reactive Oxygen Species, Mitochondrial Metabolism
Antimalarial agent 14
T22381
Synonym: 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone
Target: Others
Speract
T7487
Synonym:
Target: Others, Mitochondrial Metabolism
IMT1
T8841
Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)
Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism
L-2-Hydroxyglutaric acid disodium
T13748
Synonym: (S)-2-Hydroxyglutaric acid disodium
Target: Histone Demethylase, Mitochondrial Metabolism
CCCP
T7081
Synonym: Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone
Target: Apoptosis, IκB/IKK, COX, Mitochondrial Metabolism, STING, IFNAR, Antibacterial
Speract TFA(76901-59-2(free base))
T7487L
Synonym:
Target: Others
Ninerafaxstat trihydrochloride
T9768L
Synonym: Ninerafaxstat trihydrochloride(2254741-41-6 Free base)
Target: Others
MSDC-0602K
T38715
Synonym: MSDC-0602K,Azemiglitazone potassium
Target: PPAR
10,12-Tricosadiynoic acid
T10035
Synonym: TDA,TCDA
Target: Acyltransferase
Glutathione arsenoxide hydrochloride
T27417L
Synonym: GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)
Target: Apoptosis, AChR
ms2i6A
T33511
Synonym: ms2i6-2-6,ms2i6 2 6
Target:
NCI-006
T70032
Synonym:
Target:
Ninerafaxstat
T9768
Synonym:
Target: Others
AMPK activator 11
T79226
Synonym:
Target: Mitochondrial Metabolism
TRAP1-IN-1
T79285
Synonym:
Target: HSP
1 2
Cat No. Product Name Synonyms Targets
TN1586 Dihydrorotenone Apoptosis , Mitochondrial Metabolism
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
T8433 HQNO Mitochondrial Metabolism
HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mitochondrial NDH-2 inhibitorin many species.
T14140 Agaric acid Agaricinic Acid Mitochondrial Metabolism , AChR
Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondri...
T7922 Kresoxim-Methyl Others , Mitochondrial Metabolism , Antifungal
Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .
T0938 Thiabendazole 2-(4-Thiazolyl)benzimidazole Microtubule Associated , Mitochondrial Metabolism , Parasite
Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.
T5645 Nerol Cis-Geraniol,Neryl alcohol Apoptosis , Reactive Oxygen Species , Mitochondrial Metabolism , Endogenous Metabolite , Antifungal
Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian heart.
T2970 Rotenone Rotenon,Paraderil,Barbasco,Rotocide,Dactinol Apoptosis , Dehydrogenase , Mitochondrial Metabolism , p53 , Autophagy
Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces...
TN1362 Afzelin Kaempferol-3-O-rhamnoside PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d...
T3898 Schaftoside APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T2A2532 L-Histidine Glyoxaline-5-alanine,L-(-)-Histidine,histidine,L-Hisidine Mitochondrial Metabolism , Endogenous Metabolite
L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect ne...
T2901 Daidzin NPI-031D,Daidzein 7-O-glucoside,Daidzoside,Daidzein 7-glucoside Dehydrogenase , Reverse Transcriptase , Mitochondrial Metabolism
Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T0200 α-Lipoic Acid Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid Apoptosis , NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme ...
T5564 Tricarballylic acid β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,Carballylic acid,Propane-1,2,3-tricarboxylic acid aconitase , Mitochondrial Metabolism
Tricarballylic acid (Carballylic acid) is an inhibitor of aconitase.
T22235 Lipoic acid R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid Reactive Oxygen Species , Mitochondrial Metabolism , Endogenous Metabolite
Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
TN4883 Quinine sulfate dihydrate Others
Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassiu...
T5245 N-Isovaleroylglycine Isovaleroylglycine,N-Isovalerylglycine Others , Endogenous Metabolite
N-Isovaleroylglycine (Isovaleroylglycine) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metaboli...
T4880 L-Dihydroorotic acid Others , Endogenous Metabolite
L-Dihydroorotic acid, also known as (S)-4,5-dihydroorotate or dihydro-L-orotate, belongs to the class of organic compounds known as alpha amino acids and derivatives. Within the cell, L-dihydroorotic acid is primarily lo...
T5S1632 Barlerin 8-O-Acetylshanzhiside methyl ester,ND01 VEGFR , TNF , NF-κB , Akt , Caspase
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...
T5300 Ammonium formate Formic acid ammonium salt Others
Ammonium formate (Formic acid ammonium salt) is the simplest carboxylic acid. Formate is an intermediate in normal metabolism. It is responsible for both metabolic acidosis and disrupting mitochondrial electron transport...
T4S2326 Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside ERK , p38 MAPK , NF-κB , JNK
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...
T37177 Norcholic Acid
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of met...

Natural Products

Dihydrorotenone
TN1586
Synonym:
Target: Apoptosis, Mitochondrial Metabolism
HQNO
T8433
Synonym:
Target: Mitochondrial Metabolism
Agaric acid
T14140
Synonym: Agaricinic Acid
Target: Mitochondrial Metabolism, AChR
Kresoxim-Methyl
T7922
Synonym:
Target: Others, Mitochondrial Metabolism, Antifungal
Thiabendazole
T0938
Synonym: 2-(4-Thiazolyl)benzimidazole
Target: Microtubule Associated, Mitochondrial Metabolism, Parasite
Nerol
T5645
Synonym: Cis-Geraniol,Neryl alcohol
Target: Apoptosis, Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite, Antifungal
Rotenone
T2970
Synonym: Rotenon,Paraderil,Barbasco,Rotocide,Dactinol
Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism, p53, Autophagy
Afzelin
TN1362
Synonym: Kaempferol-3-O-rhamnoside
Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy
Schaftoside
T3898
Synonym: APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside
Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy
L-Histidine
T2A2532
Synonym: Glyoxaline-5-alanine,L-(-)-Histidine,histidine,L-Hisidine
Target: Mitochondrial Metabolism, Endogenous Metabolite
Daidzin
T2901
Synonym: NPI-031D,Daidzein 7-O-glucoside,Daidzoside,Daidzein 7-glucoside
Target: Dehydrogenase, Reverse Transcriptase, Mitochondrial Metabolism
α-Lipoic Acid
T0200
Synonym: Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid
Target: Apoptosis, NF-κB, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite
Tricarballylic acid
T5564
Synonym: β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,Carballylic acid,Propane-1,2,3-tricarboxylic acid
Target: aconitase, Mitochondrial Metabolism
Lipoic acid
T22235
Synonym: R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid
Target: Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite
Quinine sulfate dihydrate
TN4883
Synonym:
Target: Others
N-Isovaleroylglycine
T5245
Synonym: Isovaleroylglycine,N-Isovalerylglycine
Target: Others, Endogenous Metabolite
L-Dihydroorotic acid
T4880
Synonym:
Target: Others, Endogenous Metabolite
Barlerin
T5S1632
Synonym: 8-O-Acetylshanzhiside methyl ester,ND01
Target: VEGFR, TNF, NF-κB, Akt, Caspase
Ammonium formate
T5300
Synonym: Formic acid ammonium salt
Target: Others
Cornuside
T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
Norcholic Acid
T37177
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-02514 APOA4 Protein, Mouse, Recombinant (His) Mouse Yeast
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ...
TMPH-01111 COL4A1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds...
TMPH-02150 SUCLG2 Protein, Human, Recombinant (His & SUMO) Human E. coli
SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma PMID: 28709933 The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alt...
TMPH-02814 Nmes1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynt...
TMPH-00223 Alpha-S2-casein Protein, Bovine, Recombinant (His & KSI) Bovine E. coli
SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma PMID: 28709933 The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alt...
TMPH-01498 HJURP Protein, Human, Recombinant (His & SUMO) Human E. coli
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA...
TMPJ-00941 DUTPase Protein, Human, Recombinant (His) Human E. coli
Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial (dUTPase) belongs to the dUTPase family. dUTPase exits as a homotrimer and is involved in nucleotide metabolism. dUTPase produces dUMP, the immediate precurs...
TMPJ-01008 THOP1 Protein, Human, Recombinant (His) Human E. coli
Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detec...
TMPJ-00940 DUTPase Protein, Human, Recombinant Human E. coli
Deoxyuridine 5'-Triphosphate Nucleotidohydrolase Mitochondrial (dUTPase) belongs to the dUTPase family. dUTPase exits as a homotrimer and is involved in nucleotide metabolism. dUTPase produces dUMP, the immediate precurs...
TMPY-02482 Aconitase 1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and th...
TMPY-04568 PDK1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantl...
TMPJ-00933 PRDX5 Protein, Human, Recombinant (His) Human Human Cells
Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Perox...
TMPY-03445 Aspartate Aminotransferase Protein, Human, Recombinant (His) Human E. coli
GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. GOT1 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent...
TMPY-03755 Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His) Human E. coli
GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. GPD1 is a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encode...
TMPY-03495 MID1IP1 Protein, Human, Recombinant (His) Human E. coli
MID1IP1 (MID1 Interacting Protein 1) is a Protein Coding gene. The encoded protein belongs to the SPOT14 family. It is a homodimer in the absence of THRSP. MID1IP1 interacts with ACACA and ACACB. Its interaction with THR...
TMPH-01522 HIV-2 (subtype A, isolate ROD) Protein Vpx (His) HIV-2 Yeast
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the...
TMPY-04755 AK3L1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member theadenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matri...
TMPY-04469 AK3L1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member theadenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matri...
TMPH-02086 SRSF3 Protein, Human, Recombinant (GB1 & His) Human E. coli
Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic p...
TMPH-01649 PMEL Protein, Human, Recombinant (His & SUMO) Human E. coli
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPY-02799 ALDH4A1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks...
TMPH-00939 Anoctamin-5/ANO5 Protein, Human, Recombinant (His) Human HEK293
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...
TMPY-03433 ALDH4A1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks...
TMPH-01654 MAGEA1 Protein, Human, Recombinant (His) Human Yeast
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPH-01644 MMP-7 Protein, Human, Recombinant (GST) Human E. coli
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPY-05241 SIRT5 Protein, Human, Recombinant (Flag) Human E. coli
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul...
TMPY-06954 SIRT5 Protein, Human, Recombinant (His) Human E. coli
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul...
TMPJ-01450 SARS-CoV-2 Helicase Protein (His & MBP) SARS-CoV-2 E. coli
The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 ...
TMPH-02230 NRROS Protein, Human, Recombinant (His & Myc) Human Baculovirus
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02231 NRROS Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
APOA4 Protein, Mouse, Recombinant (His)
TMPH-02514
Species: Mouse
Expression System: Yeast
COL4A1 Protein, Human, Recombinant (His & SUMO)
TMPH-01111
Species: Human
Expression System: E. coli
SUCLG2 Protein, Human, Recombinant (His & SUMO)
TMPH-02150
Species: Human
Expression System: E. coli
Nmes1 Protein, Mouse, Recombinant (His & SUMO)
TMPH-02814
Species: Mouse
Expression System: E. coli
Alpha-S2-casein Protein, Bovine, Recombinant (His & KSI)
TMPH-00223
Species: Bovine
Expression System: E. coli
HJURP Protein, Human, Recombinant (His & SUMO)
TMPH-01498
Species: Human
Expression System: E. coli
dUTPase Protein, Human, Recombinant (His)
TMPJ-00941
Species: Human
Expression System: E. coli
THOP1 Protein, Human, Recombinant (His)
TMPJ-01008
Species: Human
Expression System: E. coli
dUTPase Protein, Human, Recombinant
TMPJ-00940
Species: Human
Expression System: E. coli
Aconitase 1 Protein, Human, Recombinant (His)
TMPY-02482
Species: Human
Expression System: Baculovirus-Insect Cells
PDK1 Protein, Human, Recombinant (His)
TMPY-04568
Species: Human
Expression System: Baculovirus-Insect Cells
PRDX5 Protein, Human, Recombinant (His)
TMPJ-00933
Species: Human
Expression System: Human Cells
Aspartate Aminotransferase Protein, Human, Recombinant (His)
TMPY-03445
Species: Human
Expression System: E. coli
Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His)
TMPY-03755
Species: Human
Expression System: E. coli
MID1IP1 Protein, Human, Recombinant (His)
TMPY-03495
Species: Human
Expression System: E. coli
HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
TMPH-01522
Species: HIV-2
Expression System: Yeast
AK3L1 Protein, Human, Recombinant
TMPY-04755
Species: Human
Expression System: Baculovirus-Insect Cells
AK3L1 Protein, Human, Recombinant (His & GST)
TMPY-04469
Species: Human
Expression System: Baculovirus-Insect Cells
SRSF3 Protein, Human, Recombinant (GB1 & His)
TMPH-02086
Species: Human
Expression System: E. coli
PMEL Protein, Human, Recombinant (His & SUMO)
TMPH-01649
Species: Human
Expression System: E. coli
ALDH4A1 Protein, Human, Recombinant (His & GST)
TMPY-02799
Species: Human
Expression System: Baculovirus-Insect Cells
Anoctamin-5/ANO5 Protein, Human, Recombinant (His)
TMPH-00939
Species: Human
Expression System: HEK293
ALDH4A1 Protein, Human, Recombinant
TMPY-03433
Species: Human
Expression System: Baculovirus-Insect Cells
MAGEA1 Protein, Human, Recombinant (His)
TMPH-01654
Species: Human
Expression System: Yeast
MMP-7 Protein, Human, Recombinant (GST)
TMPH-01644
Species: Human
Expression System: E. coli
SIRT5 Protein, Human, Recombinant (Flag)
TMPY-05241
Species: Human
Expression System: E. coli
SIRT5 Protein, Human, Recombinant (His)
TMPY-06954
Species: Human
Expression System: E. coli
SARS-CoV-2 Helicase Protein (His & MBP)
TMPJ-01450
Species: SARS-CoV-2
Expression System: E. coli
NRROS Protein, Human, Recombinant (His & Myc)
TMPH-02230
Species: Human
Expression System: Baculovirus
NRROS Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-02231
Species: Human
Expression System: E. coli
Cat No. Product Name
L5300 Mitochondria-Targeted Compound Library

830 compounds
A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
L1120 AMPK-Targeted Compound Library

80 compounds
80 well-chosen unique AMPK-targeted small molecules;
L2550 Glutamine Metabolism Compound Library

580 compounds
A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...
TargetMol