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Mitochondrial Metabolism

Mitochondrial metabolism encompasses pathways that generate ATP to drive intracellular unfavorable energetic reactions and produce the building blocks necessary for macromolecule synthesis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6834 FCCP 370-86-5 99.5%
FCCP
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone), a potent uncoupler of oxidative phosphorylation in mitochondria, transport protons across cell membranes...
T2970 Rotenone 83-79-4 99.48%
Rotenone
Rotenone (Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papil...
T9031 MCU-i4 371924-24-2 99.45%
MCU-i4
MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
T2607 MSDC 0160 146062-49-9 99.45%
MSDC 0160
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
T1634 Glibenclamide 10238-21-8 99.39%
Glibenclamide
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
TN1362 Afzelin 482-39-3 99.38%
Afzelin
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absor...
T16342 KL1333 1800405-30-4 99.27%
KL1333
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and...
T8433 HQNO 341-88-8 99.23%
HQNO
HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mit...
T2498 Adjudin 252025-52-8 99.05%
Adjudin
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T9235 GW604714X 853953-65-8 99.03%
GW604714X
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitoch...
T77621 Z16078526 852222-94-7 98.93%
Z16078526
Z16078526 induces endogenous Ucp1 expression, promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. Z16078526 activates thermogenic ...
T4446 Tebufenpyrad 119168-77-3 98.92%
Tebufenpyrad
Tebufenpyrad (Comanche) (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant roten...
T0412 Idebenone 58186-27-9 98.76%
Idebenone
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC)....
T9774 BAY-179 2764880-87-5 98.75%
BAY-179
BAY-179 is a potent, selective, species cross-reactive complex I inhibitor for the study of cancer.
T7081 CCCP 555-60-2 98.55%
CCCP
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the ...
T19428 Mito-TEMPO 1334850-99-5 98.5%
Mito-TEMPO
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties.
T8308 NL-1 188532-26-5 98.42%
NL-1
NL-1 is a mitoNEET inhibitor with antileukemic effect.
T0200 α-Lipoic Acid 1077-28-7 98.39%
α-Lipoic Acid
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio...
T5363 Tempo 2564-83-2 98.35%
Tempo
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a stru...
T8841 IMT1 2304621-31-4 98.14%
IMT1
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
FCCP
T6834
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone), a potent uncoupler of oxidative phosphorylation in mitochondria, transport protons across cell membranes...
Rotenone
T2970
Rotenone (Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papil...
MCU-i4
T9031
MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
MSDC 0160
T2607
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
Glibenclamide
T1634
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Afzelin
TN1362
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absor...
KL1333
T16342
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and...
HQNO
T8433
HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mit...
Adjudin
T2498
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
GW604714X
T9235
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitoch...
Z16078526
T77621
Z16078526 induces endogenous Ucp1 expression, promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. Z16078526 activates thermogenic ...
Tebufenpyrad
T4446
Tebufenpyrad (Comanche) (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant roten...
Idebenone
T0412
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC)....
BAY-179
T9774
BAY-179 is a potent, selective, species cross-reactive complex I inhibitor for the study of cancer.
CCCP
T7081
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the ...
Mito-TEMPO
T19428
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties.
NL-1
T8308
NL-1 is a mitoNEET inhibitor with antileukemic effect.
α-Lipoic Acid
T0200
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio...
Tempo
T5363
Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a stru...
IMT1
T8841
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
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TargetMol