Mitophagy

Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. In addition to the selective removal of damaged mitochondria, mitophagy is also required to adjust mitochondrial numbers to changing cellular metabolic needs, for steady-state mitochondrial turnover, and during certain cellular developmental stages, such as during cellular differentiation of red blood cells.

Cat. No.	Product name	CAS No.	Purity
T13036	Sulfosuccinimidyl oleate	135661-44-8	98%
T13036	Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Su...
T21332	U0126	109511-58-2	98%
T21332	U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
T0101	Doxazosin mesylate	77883-43-3	99.98%
T0101	Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.
T0687	Simvastatin	79902-63-9	99.95%
T0687	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cho...
T1583	Vorinostat	149647-78-9	99.93%
T1583	Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity...
T0132	Etoposide	33419-42-0	99.93%
T0132	Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide ha...
T6468	D-glutamine	5959-95-5	99.92%
T6468	D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T1764	Adezmapimod	152121-47-6	99.87%
T1764	Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autoph...
T2240	GSK2578215A	1285515-21-0	99.81%
T2240	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T0740	Metformin hydrochloride	1115-70-4	99.81%
T0740	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the...
T4S1102	Liensinine diperchlorate	5088-90-4	99.8%
T4S1102	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome...
T1637	Deferoxamine Mesylate	138-14-7	99.8%
T1637	Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulat...
T1076	Dexamethasone	50-02-2	99.77%
T1076	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
T8526	Metformin	657-24-9	99.77%
T8526	Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensit...
T1662	5-Aminolevulinic acid hydrochloride	5451-09-2	99.77%
T1662	5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.
T3043	Ruxolitinib phosphate	1092939-17-7	99.72%
T3043	Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fo...
T2534	Pitavastatin calcium	147526-32-7	99.71%
T2534	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol i...
T0649	Salicylic acid	69-72-7	99.64%
T0649	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T3015	Olaparib	763113-22-0	99.61%
T3015	Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is sel...
T5S1099	Liensinine	2586-96-1	99.56%
T5S1099	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.