Mitophagy

Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. In addition to the selective removal of damaged mitochondria, mitophagy is also required to adjust mitochondrial numbers to changing cellular metabolic needs, for steady-state mitochondrial turnover, and during certain cellular developmental stages, such as during cellular differentiation of red blood cells.

Cat. No.	Product name	CAS No.	Purity
T1662	5-Aminolevulinic acid hydrochloride	5451-09-2	99.77%
T1662	5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.
T3043	Ruxolitinib phosphate	1092939-17-7	99.72%
T3043	Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fo...
T0942	Quinacrine dihydrochloride	69-05-6	99.72%
T0942	Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and...
T2534	Pitavastatin calcium	147526-32-7	99.71%
T2534	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol i...
T0649	Salicylic acid	69-72-7	99.64%
T0649	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T5515	Hemin	16009-13-5	99.59%
T5515	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme...
T5S1099	Liensinine	2586-96-1	99.56%
T5S1099	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.
T7064	Valproic Acid	99-66-1	99.49%
T7064	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be u...
T3028	Tripterin	34157-83-0	99.48%
T3028	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripter...
T73331	GSK3-IN-3	331963-27-0	99.37%
T73331	GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 i...
T13809	P62-mediated mitophagy inducer	1809031-84-2	99.35%
T13809	P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy .
T6290	Tanespimycin	75747-14-7	99.34%
T6290	Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T2140	Parthenolide	20554-84-1	99.33%
T2140	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions...
T2099	ABT-737	852808-04-9	99.3%
T2099	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
T6062	Brefeldin A	20350-15-6	99.26%
T6062	Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation a...
T2414	Torkinib	1092351-67-1	99.23%
T2414	Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
T0972	Isoniazid	54-85-3	99.21%
T0972	Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.
T1020	Doxorubicin hydrochloride	25316-40-9	99.13%
T1020	Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
T2822	Ginsenoside Rb1	41753-43-9	99.12%
T2822	Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T2177	Kaempferol	520-18-3	99.11%
T2177	Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, ...