Mitophagy

Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. In addition to the selective removal of damaged mitochondria, mitophagy is also required to adjust mitochondrial numbers to changing cellular metabolic needs, for steady-state mitochondrial turnover, and during certain cellular developmental stages, such as during cellular differentiation of red blood cells.

Cat. No.	Product name	CAS No.	Purity
T6223	U0126-EtOH	1173097-76-1	98.65%
T6223	U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
T1879	3-Methyladenine	5142-23-4	98.44%
T1879	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autop...
T1907	Mdivi-1	338967-87-6	98.24%
T1907	Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondria...
T0374	Sunitinib Malate	341031-54-7	98.23%
T0374	Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-...
T0374L	Sunitinib	557795-19-4	98.22%
T0374L	Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activit...
T0876	Clioquinol	130-26-7	98.09%
T0876	Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potent...
T2174	Quercetin	117-39-5	98.05%
T2174	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5....
T1477	AICAR	2627-69-2	98.00%
T1477	AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treat...
T0947	Dexamethasone acetate	1177-87-3	98%
T0947	Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addi...
T6714	URB-597	546141-08-6	97.84%
T6714	URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T2870	Matrine	519-02-8	97.16%
T2870	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T12352	Oxidopamine hydrochloride	28094-15-7	96.17%
T12352	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.
T1131	Ivermectin	70288-86-7	95.35%
T1131	Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T1554	Iohexol	66108-95-0	80.18%
T1554	Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood plasma-to 844 mOsm/kg, almost three times th...
T0005	Aspirin	50-78-2	100%
T0005	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Asp...
T5515	Hemin	16009-13-5
T5515	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme...
T2830	Betulinic acid	472-15-1
T2830	Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has ...
T0972	Isoniazid	54-85-3	98%
T0972	Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.
T12352L	Oxidopamine hydrobromide	636-00-0	98%
T12352L	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.
T14149	AICAR phosphate	681006-28-0	98%
T14149	AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose ...