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Membrane transporter/Ion channel Monocarboxylate transporter

Monocarboxylate transporter

The monocarboxylate transporters, or MCTs, are a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate, across biological membranes.
Cat No. product name
T0689 D-Phenylalanine D-Phenylalanine, a necessary aromatic amino acid, is a precursor of thyroxine, dopamine, melanin, and noradrenaline (norepinephrine).
T0693 Niflumic acid Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T1768 7ACC2 7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
T3210 AZD-3965 AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1).
T5208 BAY-8002 BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively).
T5845 7-(Diethylamino)coumarin-3-carboxylic acid 7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lac...
T7460 α-Cyano-4-hydroxycinnamic acid(α-CHCA) α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50...
T14316 AR-C155858 AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).
D-Phenylalanine
T0689CAS 673-06-3
D-Phenylalanine, a necessary aromatic amino acid, is a precursor of thyroxine, dopamine, melanin, and noradrenaline (norepinephrine).
Niflumic acid
T0693CAS 4394-00-7
Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
7ACC2
T1768CAS 1472624-85-3
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
AZD-3965
T3210CAS 1448671-31-5
AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1).
BAY-8002
T5208CAS 724440-27-1
BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively).
7-(Diethylamino)coumarin-3-carboxylic acid
T5845CAS 50995-74-9
7-(Diethylamino)coumarin-3-carboxylic acid(7ACC) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lac...
α-Cyano-4-hydroxycinnamic acid(α-CHCA)
T7460CAS 28166-41-8
α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50...
AR-C155858
T14316CAS 496791-37-8
AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).