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Cat No. | Product Name | Synonyms | Targets |
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T1768 | 7ACC2 | Mitochondrial Metabolism , Monocarboxylate transporter | |
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells. | |||
T3210 | AZD3965 | AZD 3965,AZD-3965 | Monocarboxylate transporter |
AZD3965 (AZD-3965) is a selective inhibitor of monocarboxylate transporter 1 (MCT1). | |||
T5208 | BAY-8002 | BAY8002,BAY 8002 | Monocarboxylate transporter |
BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively). | |||
T14316 | AR-C155858 | Monocarboxylate transporter | |
AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM). | |||
T7460 | α-Cyano-4-hydroxycinnamic acid | α-Cyano-4-hydroxycinnamic acid(α-CHCA) | Monocarboxylate transporter |
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM). | |||
T5845 | 7ACC1 | DEAC,Coumarin D 1421,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421 | Monocarboxylate transporter |
7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistan... | |||
T67727 | MCT1-IN-3 | Monocarboxylate transporter | |
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) sho... | |||
T26221 | MCT1-IN-2 | SR13800,SR-13800,SR 13800 | |
SR13800 is a monocarboxylate transporter 1 (MCT1) inhibitor with cell-permeable. | |||
T37822 | AR-C 141990 hydrochloride | ||
Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs card... | |||
T37824 | MCT4-IN-1 | MCT4-IN-1 | |
MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate ... | |||
T70903 | KRH102053 | ||
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 an... | |||
T68511 | KRH102140 | ||
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH10214... |
Cat No. | Product Name | Synonyms | Targets |
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TN2252 | Syrosingopine | Dopamine Receptor | |
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. |
Cat No. | Product Name | Species | Expression System |
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TMPH-01528 | IHH Protein, Human, Recombinant (His) | Human | E. coli |
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine... |