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Search Results for " monocarboxylate-transporter "

Targets

12

Compounds

1

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1768 7ACC2 Mitochondrial Metabolism , Monocarboxylate transporter
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
T3210 AZD3965 AZD 3965,AZD-3965 Monocarboxylate transporter
AZD3965 (AZD-3965) is a selective inhibitor of monocarboxylate transporter 1 (MCT1).
T5208 BAY-8002 BAY8002,BAY 8002 Monocarboxylate transporter
BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively).
T14316 AR-C155858 Monocarboxylate transporter
AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).
T7460 α-Cyano-4-hydroxycinnamic acid α-Cyano-4-hydroxycinnamic acid(α-CHCA) Monocarboxylate transporter
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
T5845 7ACC1 DEAC,Coumarin D 1421,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421 Monocarboxylate transporter
7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistan...
T67727 MCT1-IN-3 Monocarboxylate transporter
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) sho...
T26221 MCT1-IN-2 SR13800,SR-13800,SR 13800
SR13800 is a monocarboxylate transporter 1 (MCT1) inhibitor with cell-permeable.
T37822 AR-C 141990 hydrochloride
Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs card...
T37824 MCT4-IN-1 MCT4-IN-1
MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate ...
T70903 KRH102053
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 an...
T68511 KRH102140
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH10214...
Cat No. Product Name Synonyms Targets
TN2252 Syrosingopine Dopamine Receptor
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01528 IHH Protein, Human, Recombinant (His) Human E. coli
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine...
TargetMol