Home Tools
Log in
Cart

NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T10964L DB1976 dihydrochloride 2369663-93-2 99.08%
DB1976 dihydrochloride
DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and...
TN4383 Kazinol U 1238116-48-7 98%
Kazinol U
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
T3775 Armepavine 524-20-9
Armepavine
Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experime...
TN4394 Kobophenol A 124027-58-3 98%
Kobophenol A
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TP1373L Ac2-26 acetate 98%
Ac2-26 acetate
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1). Ac2-26 acetate decreases AnxA1 protein expression and inhibits the activation of NF-κB and M...
TN1694 Gliotoxin 67-99-2 98%
Gliotoxin
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
TN3635 Chlojaponilactone B 1449382-91-5 98%
Chlojaponilactone B
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN4938 Samidin 477-33-8 98%
Samidin
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
T78095 Demethyleneberberine chloride 16705-03-6 98%
Demethyleneberberine chloride
Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-κB...
T78750 NF-κB-IN-10 98%
NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviating ...
T78816 Anti-osteoporosis agent-4 98%
Anti-osteoporosis agent-4
Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively in...
T78882 NF-κB-IN-12 98%
NF-κB-IN-12
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].
T79130 COX-2-IN-32 2725863-08-9 98%
COX-2-IN-32
COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression. Demonstrating anti-inflammatory properties, it impedes N...
T79507 Anti-inflammatory agent 48 98%
Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatory ag...
T79585 Anti-inflammatory agent 50 98%
Anti-inflammatory agent 50
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and T...
T79671 NF-κB-IN-11 2768833-35-6 98%
NF-κB-IN-11
NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB. It also r...
T79790 ALPK1-IN-3 2765633-73-4 98%
ALPK1-IN-3
ALPK1-IN-3, derived from patent WO2022063153A1 compound T007, serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhance...
T79930 Sanggenon A 76464-71-6 98%
Sanggenon A
Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it signi...
T79932 Eudebeiolide B 1934299-51-0 98%
Eudebeiolide B
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is ...
T79933 (−)-N-Hydroxyapiosporamide 1205676-02-3 98%
(−)-N-Hydroxyapiosporamide
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has po...
DB1976 dihydrochloride
T10964L
DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and...
Kazinol U
TN4383
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
Armepavine
T3775
Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experime...
Kobophenol A
TN4394
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
Ac2-26 acetate
TP1373L
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1). Ac2-26 acetate decreases AnxA1 protein expression and inhibits the activation of NF-κB and M...
Gliotoxin
TN1694
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
Chlojaponilactone B
TN3635
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
Samidin
TN4938
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Demethyleneberberine chloride
T78095
Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-κB...
NF-κB-IN-10
T78750
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviating ...
Anti-osteoporosis agent-4
T78816
Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively in...
NF-κB-IN-12
T78882
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].
COX-2-IN-32
T79130
COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression. Demonstrating anti-inflammatory properties, it impedes N...
Anti-inflammatory agent 48
T79507
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatory ag...
Anti-inflammatory agent 50
T79585
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and T...
NF-κB-IN-11
T79671
NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB. It also r...
ALPK1-IN-3
T79790
ALPK1-IN-3, derived from patent WO2022063153A1 compound T007, serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhance...
Sanggenon A
T79930
Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it signi...
Eudebeiolide B
T79932
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is ...
(−)-N-Hydroxyapiosporamide
T79933
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has po...
1 2 3 4 5 ... 21
TargetMol