T10964L |
DB1976 dihydrochloride
|
2369663-93-2
|
99.08%
|
|
DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and...
|
TN4383 |
Kazinol U
|
1238116-48-7
|
98%
|
|
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
|
T3775 |
Armepavine
|
524-20-9
|
|
|
Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experime...
|
TN4394 |
Kobophenol A
|
124027-58-3
|
98%
|
|
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
|
TP1373L |
Ac2-26 acetate
|
|
98%
|
|
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1). Ac2-26 acetate decreases AnxA1 protein expression and inhibits the activation of NF-κB and M...
|
TN1694 |
Gliotoxin
|
67-99-2
|
98%
|
|
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
|
TN3635 |
Chlojaponilactone B
|
1449382-91-5
|
98%
|
|
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
|
TN4938 |
Samidin
|
477-33-8
|
98%
|
|
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
|
T78095 |
Demethyleneberberine chloride
|
16705-03-6
|
98%
|
|
Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-κB...
|
T78750 |
NF-κB-IN-10
|
|
98%
|
|
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviating ...
|
T78816 |
Anti-osteoporosis agent-4
|
|
98%
|
|
Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively in...
|
T78882 |
NF-κB-IN-12
|
|
98%
|
|
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].
|
T79130 |
COX-2-IN-32
|
2725863-08-9
|
98%
|
|
COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression. Demonstrating anti-inflammatory properties, it impedes N...
|
T79507 |
Anti-inflammatory agent 48
|
|
98%
|
|
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatory ag...
|
T79585 |
Anti-inflammatory agent 50
|
|
98%
|
|
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and T...
|
T79671 |
NF-κB-IN-11
|
2768833-35-6
|
98%
|
|
NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB. It also r...
|
T79790 |
ALPK1-IN-3
|
2765633-73-4
|
98%
|
|
ALPK1-IN-3, derived from patent WO2022063153A1 compound T007, serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhance...
|
T79930 |
Sanggenon A
|
76464-71-6
|
98%
|
|
Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it signi...
|
T79932 |
Eudebeiolide B
|
1934299-51-0
|
98%
|
|
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is ...
|
T79933 |
(−)-N-Hydroxyapiosporamide
|
1205676-02-3
|
98%
|
|
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has po...
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