NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T1930	JSH-23	749886-87-1	99.67%
T1930	JSH-23, an NF-κB inhibitor（IC50= 7.1 μM）, suppresses the transcriptional activity.
T5S2228	6‴-Feruloylspinosin	77690-92-7	99.65%
T5S2228	6‴-Feruloylspinosin (6'''-Feruloylspinosin) may possess anti-inflammatory activity.
T17157	TRAF-STOP inhibitor 6877002	433249-94-6	99.65%
T17157	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor), is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and redu...
TN1721	Gypenoside L	94987-09-4	99.65%
TN1721	Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also i...
T3S0807	Berbamine	478-61-5	99.64%
T3S0807	Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardio...
TN1833	Karacoline	39089-30-0	99.64%
TN1833	Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway...
T13265	Urolithin B	1139-83-9	99.64%
T13265	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical frui...
T1229	Erdosteine	84611-23-4	99.63%
T1229	Erdosteine (RV 144) is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate muc...
T5764	Alliin	556-27-4	99.62%
T5764	Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induce...
T4S1881	Aconine	509-20-6	99.61%
T4S1881	1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.
TN1273	7,4'-Dihydroxyflavone	2196-14-7	99.6%
TN1273	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-...
T4S0217	HOMOPLANTAGININ	17680-84-1	99.6%
T4S0217	Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
TN1079	Deoxyelephantopin	29307-03-7	99.6%
TN1079	Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, P...
T4S1050	Pristimerin	1258-84-0	99.59%
T4S1050	1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced m...
T8550	NDMC101	1308631-40-4	99.59%
T8550	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 a...
T9115	Vanillic Acid	121-34-6	99.58%
T9115	Vanillic Acid (Acide vanillique) is used as a condiment in food,which used in wine and vinegar. It is an intermediate in the production of vanillin from ferulic ...
T3729	Ethyl gallate	831-61-8	99.58%
T3729	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytot...
T24816	SP-100030	154563-54-9	99.57%
T24816	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces...
T13686	Ergolide	54999-07-4	99.56%
T13686	Ergolide, a sesquiterpene lactone extracted from the dried flowers of Inula Britannica, effectively hinders the expression of inducible nitric oxide synthase and...
T23911	CPS-11	145945-21-7	99.55%
T23911	CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent ...