NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T3954	Adelmidrol	1675-66-7	99.35%
T3954	Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
TN1620	Eriocalyxin B	84745-95-9	99.35%
TN1620	Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
T27012	Chrysotoxine	156951-82-5	99.34%
T27012	Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mit...
T6S1495	Ginsenoside Rk3	364779-15-7	99.33%
T6S1495	1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparatio...
T2140	Parthenolide	20554-84-1	99.33%
T2140	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions...
TN4234	Hydrangenol	480-47-7	99.33%
TN4234	Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...
T4S1962	Beta-Asarone	5273-86-9	99.32%
T4S1962	1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing RO...
T25450	GGTI 2147	191102-87-1	99.32%
T25450	GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
T3416	Aucubin	479-98-1	99.31%
T3416	Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T6S1141	Ganoderic acid A	81907-62-2	99.31%
T6S1141	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganode...
T23911	CPS-11	145945-21-7	99.30%
T23911	CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent ...
T9105	NF-κB-IN-1	1227098-15-8	99.29%
T9105	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhib...
T5S0754	Isoquercetin	482-35-9	99.29%
T5S0754	1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as ...
T16324	Nimbolide	25990-37-8	99.28%
T16324	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis th...
TN1525	Convallatoxin	508-75-8	99.27%
TN1525	Convallatoxin is a natural product
T6718	Zingerone	122-48-5	99.26%
T6718	Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipol...
T16706	Quinoclamine	2797-51-5	99.25%
T16706	Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
T2898	Andrographolide	5508-58-7	99.18%
T2898	Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential a...
T5S2129	Sciadopitysin	521-34-6	99.17%
T5S2129	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
T6204	QNZ	545380-34-5	99.17%
T6204	QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.