NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T2179	Triptolide	38748-32-2	98.52%
T2179	Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive,...
T3S1707	Dendrophenol	108853-14-1	98.51%
T3S1707	Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.
TN2309	Withanolide A	32911-62-9	98.49%
TN2309	Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
T4S1615	Sanggenon C	80651-76-9	98.49%
T4S1615	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the...
TQ0131	Rocaglamide	84573-16-0	98.46%
TQ0131	Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of N...
T3251	Stachydrine Hydrochloride	4136-37-2	98.45%
T3251	Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.
TN2063	Physalin B	23133-56-4	98.40%
TN2063	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
T0200	α-Lipoic Acid	1077-28-7	98.39%
T0200	α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio...
TMA0507	Tomatidine	77-59-8	98.38%
TMA0507	Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C....
T8981	WAY-169916	669764-18-5	98.37%
T8981	WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estr...
T4237	Rubiadin-1-methyl ether	7460-43-7	98.32%
T4237	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p6...
T15204	EHT 1610	1425945-60-3	98.27%
T15204	EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on ...
T6S1371	Isovitexin	38953-85-4	98.24%
T6S1371	1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase i...
T125120	Cyclo(L-Pro-L-Val)	2854-40-2	98.18%
T125120	Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
T9582	CLEFMA	1246964-32-8	98.17%
T9582	CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
T6S1256	Ruscogenin	472-11-7	98.12%
T6S1256	1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
T3S0335	Soyasaponin Bb	51330-27-9	98.11%
T3S0335	1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiti...
T10809L	CHPG hydrochloride	T10809L	98.1%
T10809L	CHPG hydrochloride is a selective agonist of mGluR5.
T17217	Vamorolone	13209-41-1	98.04%
T17217	Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side...
T2P2870	Damascenone	23696-85-7	98.03%
T2P2870	Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.