NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T6S1141	Ganoderic acid A	81907-62-2	98%
T6S1141	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganode...
T3S0738	Yangonin	500-62-9	98%
T3S0738	Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate fo...
T0646	5-Aminosalicylic Acid	89-57-6	97.88%
T0646	5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is consid...
T3627	IQ-1S free acid	23146-22-7	97.82%
T3627	IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inf...
T4S1615	Sanggenon C	80651-76-9	97.76%
T4S1615	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the...
T4S1658	Benzoyloxypaeoniflorin	72896-40-3	97.64%
T4S1658	Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet ...
TMA1570	Sappanone A	102067-84-5	97.48%
TMA1570	Sappanone A is a high isoflavanone that exhibits anti-inflammatory effects by modulating Nrf2.Sappanone A attenuates allergic airway inflammation in ovalbumin-in...
TN1016	Kukoamine A	75288-96-9	97.45%
TN1016	Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T6485	Embelin	550-24-3	97.07%
T6485	Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T1296	4-Aminosalicylic acid	65-49-6	97.07%
T1296	4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T63119	NF-κB/MAPK-IN-1	2413940-56-2	97.03%
T63119	NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition ...
T25150	BI-69A11	1233322-09-2	96.97%
T25150	BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
T3012	Mangiferin	4773-96-0	96.74%
T3012	Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.
T3893	Forsythoside B	81525-13-5	96.52%
T3893	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response an...
TN1576	Diallyl disulfide	2179-57-9	95%
TN1576	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
T17214	Valencene	4630-07-3	86.9%
T17214	Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene...
T11060	DMAPT	870677-05-7	100.00%
T11060	DMAPT (Dimethylamino Parthenolide) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary ac...
T6S1572	Sauchinone	177931-17-8	100%
T6S1572	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
T3005	4-Hydroxychalcone	20426-12-4	100%
T3005	4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
T10808	CHPG sodium salt	1303993-73-8	100%
T10808	CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...