NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
TN3708	Coronarin D	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
TN4652	Niazimicin	147821-49-6	98%
TN4652	Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
TN5011	Shizukaol B	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T7980	Hesperidin methylchalcone	24292-52-2	98%
T7980	Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting ...
T13625	Coronalolic acid	268214-52-4	98%
T13625	Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
T21577	Narasin (sodium salt)	58331-17-2	98%
T21577	Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and in...
T10318	Anatabine dicitrate	T10318	98%
T10318	Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β...
TN2164	Rubipodanone A	2170211-22-8	98%
TN2164	Rubipodanone A is a natural product
TN4774	Physalin A	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1143	1-O-Acetyl britannilactone	681457-46-5	98%
TN1143	1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR...
TN1846	Kushenol W	254886-76-5	98%
TN1846	Kushenol W is a natural product
TN4437	Licorisoflavan A	129314-37-0	98%
TN4437	Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
TN1347	8-Prenylkaempferol	28610-31-3	98%
TN1347	8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TN3298	8alpha-Hydroxyhirsutinolide	1394156-45-6	98%
TN3298	8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-ÎºB activity with the IC(50) value of 1.9 uM.
TN2177	Sanggenol L	329319-20-2	98%
TN2177	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopto...
TN2178	Sanggenone H	86450-80-8	98%
TN2178	Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated m...
TN2327	Zedoarondiol	98644-24-7	98%
TN2327	Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
T72869	IMD-biphenylA	2928463-40-3	98%
T72869	IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune potent...
T72870	IMD-biphenylB	2928463-41-4	98%
T72870	IMD-biphenylB, an imidazoquinolinone-based dimer, acts as a potent NF-κB immunomodulator, inhibiting tumor proliferation with minimal systemic inflammation and d...
T72871	IMD-biphenylC	2928463-42-5	98%
T72871	IMD-biphenylC is a novel imidazoquinolinone dimer functioning as an NF-κB immunomodulator. It effectively inhibits tumor proliferation and simultaneously induces...