NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T1144	Lidocaine hydrochloride	73-78-9	99.83%
T1144	Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and...
TN3609	Catalposide	6736-85-2	99.82%
TN3609	Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
T3877	Esculentoside A	65497-07-6	99.81%
T3877	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. E...
T7030	Anemarsaponin B	139051-27-7	99.81%
T7030	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
TN6726	Methyl chlorogenate	29708-87-0	99.80%
TN6726	Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.
TN6730	Epoxyazadiradione	18385-59-6	99.8%
TN6730	Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
TN1786	Isomerazin	1088-17-1	99.8%
TN1786	Isomerazin (Isomeranzin) has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathw...
TN2232	Soyasaponin Ab	118194-13-1	99.79%
TN2232	Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
T2921	Sinomenine hydrochloride	6080-33-7	99.79%
T2921	Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.
T4S0969	Obtusifolin	477-85-0	99.79%
T4S0969	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppre...
T2872	Ginsenoside Re	52286-59-6	99.78%
T2872	Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.
T0020	Sodium 4-aminosalicylate dihydrate	6018-19-5	99.78%
T0020	Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA...
TQ0169	Inulicin	33627-41-7	99.77%
TQ0169	Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
T3384	Wedelolactone	524-12-9	99.76%
T3384	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T2930	α-Lipoic Acid	62-46-4	99.76%
T2930	α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hep...
T2794	Astilbin	29838-67-3	99.76%
T2794	Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T5S1097	Neferine	2292-16-2	99.75%
T5S1097	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Nefer...
T0468	Lidocaine	137-58-6	99.74%
T0468	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation o...
T14491	B022	1202764-53-1	99.74%
T14491	B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protec...
T9656	AP-1/NF-κB activation inhibitor 1	188936-12-1	99.74%
T9656	AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcripti...