nod like receptor (nlr) — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3587	NOD-IN-1	Compound 4	NOD-like Receptor (NLR) , NOD
	NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.		NOD-like Receptor (NLR) , NOD
T15052	Dapansutrile		NOD-like Receptor (NLR) , NOD
	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.		NOD-like Receptor (NLR) , NOD
T13375	YQ128		IL Receptor , NOD-like Receptor (NLR) , NOD , Interleukin
	YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
T4217	INF39		NOD-like Receptor (NLR) , NOD
	INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.		NOD-like Receptor (NLR) , NOD
T4164	CY-09	CY 09	NOD-like Receptor (NLR) , NOD
	CY-09 is an NLRP3 inhibitor.		NOD-like Receptor (NLR) , NOD
T8828	CP 424174		IL Receptor
	CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.		IL Receptor
T38361	GSK717		IL Receptor , NOD
	GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio...		IL Receptor , NOD
T16159	Muramyl dipeptide	MDP	NOD
	Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation...		NOD
T3701	MCC950	CP-456773	NOD
	CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and...		NOD
T6454	CORM-3	CORM3	Others , NF-κB , NOD-like Receptor (NLR)
	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.		Others , NF-κB , NOD-like Receptor (NLR)
T6591	Nodinitib-1	ML130,CID-1088438	TNF , NOD-like Receptor (NLR) , NOD
	Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.		TNF , NOD-like Receptor (NLR) , NOD
T28178	NLRP3-IN-9	INF-4E,INF 4E,INF4E	NOD
	NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ...		NOD
T1404	Stavudine	d4T,Sanilvudine,BMY-27857,NSC 163661	Apoptosis , Nucleoside Antimetabolite/Analog , HIV Protease , NOD-like Receptor (NLR) , Reverse Transcriptase , Autophagy
	Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
T2131	Articaine hydrochloride	Ultracaine,Articaine HCl,Hoe-045	Sodium Channel
	Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.		Sodium Channel
T6887	MCC950 sodium	CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950	NOD-like Receptor (NLR) , NOD
	MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs). MCC950 sodium has no effect on other inflammatory vesicles such as AIM2...		NOD-like Receptor (NLR) , NOD
T3230	NLRP3-IN-2	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR) , NOD
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...		NOD-like Receptor (NLR) , NOD
T9222	Emlenoflast	MCC7840	NOD-like Receptor (NLR) , NOD
	Emlenoflast (MCC7840) is a selective inhibitor of NLRP3 inflammasome.		NOD-like Receptor (NLR) , NOD

Compounds

NOD-IN-1

T3587

Synonym: Compound 4

Target: NOD-like Receptor (NLR), NOD

Dapansutrile

T15052

Synonym:

Target: NOD-like Receptor (NLR), NOD

YQ128

T13375

Synonym:

Target: IL Receptor, NOD-like Receptor (NLR), NOD, Interleukin

INF39

T4217

Synonym:

Target: NOD-like Receptor (NLR), NOD

CY-09

T4164

Synonym: CY 09

Target: NOD-like Receptor (NLR), NOD

CP 424174

T8828

Synonym:

Target: IL Receptor

GSK717

T38361

Synonym:

Target: IL Receptor, NOD

Target: Others, NF-κB, NOD-like Receptor (NLR)

Nodinitib-1

T6591

Synonym: ML130,CID-1088438

Target: TNF, NOD-like Receptor (NLR), NOD

NLRP3-IN-9

T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Stavudine

T1404

Synonym: d4T,Sanilvudine,BMY-27857,NSC 163661

Target: Apoptosis, Nucleoside Antimetabolite/Analog, HIV Protease, NOD-like Receptor (NLR), Reverse Transcriptase, Autophagy

Articaine hydrochloride

T2131

Synonym: Ultracaine,Articaine HCl,Hoe-045

Target: Sodium Channel

MCC950 sodium

T6887

Synonym: CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950

Target: NOD-like Receptor (NLR), NOD

NLRP3-IN-2

T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Emlenoflast

T9222

Synonym: MCC7840

Target: NOD-like Receptor (NLR), NOD

Cat No.	Product Name	Synonyms	Targets
T6S1256	Ruscogenin		NOS , NF-κB , NOD-like Receptor (NLR)
	1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein ...		NOS , NF-κB , NOD-like Receptor (NLR)
T0772	Troxerutin	Trihydroxyethylrutin	NOD-like Receptor (NLR)
	Troxerutin (Trihydroxyethylrutin), a natural bioflavonoid, is isolated from Sophora japonica. It has many benefits and medicinal properties.		NOD-like Receptor (NLR)
TQ0165	Arglabin	(+)-Arglabin	NOD-like Receptor (NLR) , Transferase , NOD , Autophagy
	Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
T4S0350	Licochalcone B		Beta Amyloid , Others
	1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc...		Beta Amyloid , Others
T3092	Nigericin sodium salt		Potassium Channel , NOD-like Receptor (NLR) , Antibacterial , Antibiotic , NOD
	Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-...
T2893	Muscone	3-Methylcyclopentadecanone,Methylexaltone	MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T5247	Trimethylamine N-oxide dihydrate	TMANO Dihydrate	Others , Endogenous Metabolite
	Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.		Others , Endogenous Metabolite