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NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN1009 Epimagnolin B 1134188-26-3 98%
Epimagnolin B
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
T36512 PTIO 18390-00-6 98%
PTIO
PTIO is a specific scavenger of NO. PTIO reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be used to examine nitric o...
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 113981-49-0 98%
5-Hydroxy-7,8-dimethoxyflavanone
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
TN4160 Goniothalamin 17303-67-2 98%
Goniothalamin
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
T36033 DETA NONOate 146724-94-9 98%
DETA NONOate
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents ...
TN5019 Siegeskaurolic acid 52645-97-3 98%
Siegeskaurolic acid
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN1102 Physalin L 113146-74-0 98%
Physalin L
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
TN1086 Dehydrotrametenolic acid 6879-05-6 98%
Dehydrotrametenolic acid
Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
TN5387 Grasshopper ketone 41703-38-2 98%
Grasshopper ketone
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory e...
TQ0073 Andropanolide 869807-57-8 98%
Andropanolide
Andropanolide is a dipterocarbon from Andrographis paniculata with anti-HIV, antimalarial and anticancer activities and inhibits Lipopolysaccharides (LPS)-stimul...
TN2167 Rutaevin 33237-37-5 99.99%
Rutaevin
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
TN1006 Tirucallol 514-46-5 99.98%
Tirucallol
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action re...
TQ0301 Kuwanon A 62949-77-3 99.96%
Kuwanon A
Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.
TN1949 Moracin C 69120-06-5 99.86%
Moracin C
Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release ...
TN3609 Catalposide 6736-85-2 99.82%
Catalposide
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
TN1295 5-O-Caffeoylshikimic acid 73263-62-4 99.82%
5-O-Caffeoylshikimic acid
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
T7030 Anemarsaponin B 139051-27-7 99.81%
anemarsaponin B
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T3770 Taraxasterol 1059-14-9 99.79%
Taraxasterol
Taraxasterol (Taraxasterin) is compound with anti-inflammatory activity.
TN4228 Hulupinic acid 1891-42-5 99.76%
Hulupinic acid
Hulupinic acid is the main oxidation product of hop acid, which may inhibit the production of NO in macrophages RAW 264.7 cells.
T0670 L-Arginine hydrochloride 1119-34-2 99.74%
L-Arginine hydrochloride
L-Arginine hydrochloride is a nitrogen donor for synthesis of nitric oxide.
Epimagnolin B
TN1009
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
PTIO
T36512
PTIO is a specific scavenger of NO. PTIO reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be used to examine nitric o...
5-Hydroxy-7,8-dimethoxyflavanone
TN3119
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
Goniothalamin
TN4160
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
DETA NONOate
T36033
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents ...
Siegeskaurolic acid
TN5019
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
Physalin L
TN1102
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
Dehydrotrametenolic acid
TN1086
Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
Grasshopper ketone
TN5387
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory e...
Andropanolide
TQ0073
Andropanolide is a dipterocarbon from Andrographis paniculata with anti-HIV, antimalarial and anticancer activities and inhibits Lipopolysaccharides (LPS)-stimul...
Rutaevin
TN2167
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
Tirucallol
TN1006
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action re...
Kuwanon A
TQ0301
Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.
Moracin C
TN1949
Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release ...
Catalposide
TN3609
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
5-O-Caffeoylshikimic acid
TN1295
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
anemarsaponin B
T7030
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
Taraxasterol
T3770
Taraxasterol (Taraxasterin) is compound with anti-inflammatory activity.
Hulupinic acid
TN4228
Hulupinic acid is the main oxidation product of hop acid, which may inhibit the production of NO in macrophages RAW 264.7 cells.
L-Arginine hydrochloride
T0670
L-Arginine hydrochloride is a nitrogen donor for synthesis of nitric oxide.
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TargetMol