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NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1102 Mifepristone 84371-65-3 99.74%
Mifepristone
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1479 Isosorbide dinitrate 87-33-2 99.72%
Isosorbide dinitrate
Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.
TN1691 Glabrol 59870-65-4 99.72%
Glabrol
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T3S0364 L-Arginine 74-79-3 99.71%
L-Arginine
1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabe...
TN1463 Calycanthoside 483-91-0 99.69%
Calycanthoside
Calycanthoside (Isofraxidin 7-O-beta-D-Glucoside) is a natural compound isolated from Angelica tenuissima. Calycanthoside shows anti-inflammatory and antibacteri...
T3S0870 Paederosidic acid methyl ester 122413-01-8 99.67%
Paederosidic acid methyl ester
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
T3811 Ginsenoside C-K 39262-14-1 99.65%
Ginsenoside C-K
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
T4124 IKarisoside A 55395-07-8 99.64%
IKarisoside A
IKarisoside A(Baohuoside II) is a flavonol glycoside from the Berberidaceae plant Epimedium, with anti-inflammatory activity.
T3918 Ginsenoside Rb3 68406-26-8 99.63%
Ginsenoside Rb3
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits ...
T77650 Topoisomerase II inhibitor 14 305343-00-4 99.62%
Topoisomerase II inhibitor 14
Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis a...
TN6985 Anhydronotoptol 88206-51-3 99.61%
Anhydronotoptol
Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one), a natural compound extracted from the umbelliferae plant Qiangw...
TN1413 Atranorin 479-20-9 99.57%
Atranorin
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent ...
T2758 Madecassic acid 18449-41-7 99.55%
Madecassic acid
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.
T2791 Pectolinarin 28978-02-1 99.47%
Pectolinarin
Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
TN1238 3,4-O-Isopropylidene-shikimic acid 183075-03-8 99.47%
3,4-O-Isopropylidene-shikimic acid
3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it ha...
T3847 Asperuloside 14259-45-1 99.42%
Asperuloside
Asperuloside (Asperulosid) has anti-inflammatory activity.
TN1705 Glycyrrhisoflavone 116709-70-7 99.4%
Glycyrrhisoflavone
Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.
TN2139 Regaloside B 114420-67-6 99.4%
Regaloside B
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity.
T9113 Myristicin 607-91-0 99.34%
Myristicin
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
T7992 4-Hydroxyflavanone 6515-37-3 99.34%
4-Hydroxyflavanone
4-Hydroxyflavanone is a natural product, shows full vasorelaxing effects
Mifepristone
T1102
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
Isosorbide dinitrate
T1479
Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.
Glabrol
TN1691
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
L-Arginine
T3S0364
1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabe...
Calycanthoside
TN1463
Calycanthoside (Isofraxidin 7-O-beta-D-Glucoside) is a natural compound isolated from Angelica tenuissima. Calycanthoside shows anti-inflammatory and antibacteri...
Paederosidic acid methyl ester
T3S0870
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
Ginsenoside C-K
T3811
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
IKarisoside A
T4124
IKarisoside A(Baohuoside II) is a flavonol glycoside from the Berberidaceae plant Epimedium, with anti-inflammatory activity.
Ginsenoside Rb3
T3918
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits ...
Topoisomerase II inhibitor 14
T77650
Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis a...
Anhydronotoptol
TN6985
Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one), a natural compound extracted from the umbelliferae plant Qiangw...
Atranorin
TN1413
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent ...
Madecassic acid
T2758
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.
Pectolinarin
T2791
Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
3,4-O-Isopropylidene-shikimic acid
TN1238
3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it ha...
Asperuloside
T3847
Asperuloside (Asperulosid) has anti-inflammatory activity.
Glycyrrhisoflavone
TN1705
Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.
Regaloside B
TN2139
Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B is a phenylpropanoid isolated from Lilium longiflorum.It has anti-inflammatory activity.
Myristicin
T9113
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
4-Hydroxyflavanone
T7992
4-Hydroxyflavanone is a natural product, shows full vasorelaxing effects
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TargetMol