NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.

Cat. No.	Product name	CAS No.	Purity
T19032	Nitro blue tetrazolium chloride	298-83-9	98.93%
T19032	Nitro blue tetrazolium chloride (NBT) is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 M). A well-known scavenger of...
TN1134	Euscaphic acid	53155-25-2	98.93%
TN1134	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
TN1041	Quercimeritrin	491-50-9	98.84%
TN1041	Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) has antibacterial activity, it shows promising activity against Staphylococcus aureus.
TN1675	Gardenin B	2798-20-1	98.71%
TN1675	Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
T1322	Bendazol	621-72-7	98.7%
T1322	Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.
T6S1665	Irisflorentin	41743-73-1	98.6%
T6S1665	1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-...
T40335	AChE-IN-3	2713548-95-7	98.59%
T40335	AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.
T3S0006	(E)-Ferulic acid methyl ester	22329-76-6	98.22%
T3S0006	(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...
TN1222	26-Deoxyactein	264624-38-6	98.06%
TN1222	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity...
T5684	Ethyl 3,4-dihydroxybenzoate	3943-89-3	98%
T5684	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T12808	S-Nitroso-N-acetyl-DL-penicillamine	67776-06-1	98%
T12808	S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and .
T5838	L-Canavanine sulfate	2219-31-0	98%
T5838	L-Canavanine sulfate is a selective inducible NO synthase inhibitor.
T5681	ETHYL CAFFEATE	102-37-4	98%
T5681	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely block...
TN1803	Isoscoparin	20013-23-4	97.95%
TN1803	Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
TN3176	6-Methoxynaringenin	94942-49-1	97.87%
TN3176	6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.
T0006	Methylene Blue trihydrate	7220-79-3	97.61%
T0006	Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water o...
T7597	6-Biopterin	22150-76-1	95.95%
T7597	6-Biopterin (L-Biopterin) is a natural product,is a NO synthase cofactor.
T62899	Tau-aggregation and neuroinflammation-IN-1	2175953-98-5	100%
T62899	Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-lengt...
T6S2023	Harpagoside	19210-12-9	100%
T6S2023	1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit li...
TN1546	Dactylorhin A	256459-34-4	100%
TN1546	Dactylorhin A, a succinate derivative ester isolated from the rhizomes of Gymnadenia conopsea, demonstrates a moderate inhibitory effect on nitric oxide (NO) pro...