NPC1L1

Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract epithelial cells as well as in hepatocytes. Specifically, it appears to bind to a critical mediator of cholesterol absorption.

Cat. No.	Product name	CAS No.	Purity
T4S1421	Praeruptorin B	73069-28-0	98%
Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...
T11251	Ezetimibe ketone	191330-56-0	98%
Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone ...
TN6751	1-HEXACOSANOL	506-52-5
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T7798	FGH10019	1046045-61-7	98.93%
FGH-10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
T4317	PF 429242	947303-87-9	99.27%
PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease ...
T6832	Fatostatin hydrobromide	298197-04-3	99.91%
Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
T1593	Ezetimibe	163222-33-1	99.97%
Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T4S1421

Praeruptorin B

73069-28-0

98%

Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via t...

T11251

Ezetimibe ketone

191330-56-0

98%

Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone ...

TN6751

1-HEXACOSANOL

506-52-5

Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.

T7798

FGH10019

1046045-61-7

98.93%

FGH-10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).

T4317

PF 429242

947303-87-9

99.27%

PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease ...

T6832

Fatostatin hydrobromide

298197-04-3

99.91%

Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.

T1593

Ezetimibe

163222-33-1

99.97%

Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.