Neurokinin receptor

Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. NK-1 antagonists boost the efficacy of 5-HT3 antagonists to prevent nausea and vomiting. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy.

Cat No.	product name
T10688	Casopitant mesylate	Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of ant...
T10892	CS-003 Free base	CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3...
T13329	Vofopitant	Vofopitant is a potent antagonist of the tachykinin NK1 receptor (pKis: 10.6, 9.5, and 9.8 for the human, rat, and ferret NK1 receptor, respectively).
T13329L	Vofopitant dihydrochloride	Vofopitant dihydrochloride is a selective and orally available antagonist of tachykinin neurokinin 1(NK1) receptor (pKi: 9.5 and 10.6 in rat and human membranes...
T16406	Orvepitant maleate	Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitan...
T1743	Aprepitant	Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inh...
T1790	Fosaprepitant dimeglumine	Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Up...
T19518	Physalaemin	Physalaemin is a non-mammalian tachykinin.
T3716	Rolapitant	Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
T3724	Rolapitant hydrochloride	Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
T6905	Netupitant	Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
T7209	Maropitant	Maropitant is a selective neurokinin (NK1) receptor antagonist.
T7549	Talnetant	Talnetant is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransm...
T7633	Senktide	Senktide is an agonist of tachykinin NK3 receptor.
T7828	Bhsar-sp	Bhsar-sp is an agonist of NK1 receptor.
T8235	L-732138	L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
T8789	N-Acetyl-L-tryptophan	N-Acetyl-L-tryptophan is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).
TP1008	Neurokinin A	Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
TP1008	Neurokinin A	Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
TP1086	Men 10376 TFA(135306-85-3,free)	Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
TP1087	Substance P	Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
TP1385	Neurokinin A(4-10) TFA(97559-35-8 free base)	Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1].
TP1572	GR-73632	Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
TP1772L	Hemokinin 1 (mouse) acetate(208041-90-1 free base)	Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 rece...
TP1883	[Lys5,MeLeu9,Nle10]-NKA(4-10)	Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).