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Neuroscience Neurokinin 1

Neurokinin 1

Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. NK-1 antagonists boost the efficacy of 5-HT3 antagonists to prevent nausea and vomiting. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy.
Cat No. product name
T1743 Aprepitant Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inh...
T1790 Fosaprepitant dimeglumine Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Up...
T3716 Rolapitant Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
T3724 Rolapitant hydrochloride Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
T6905 Netupitant Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
T7209 Maropitant Maropitant is a selective neurokinin (NK1) receptor antagonist.
T19518 Physalaemin Physalaemin is a non-mammalian tachykinin.
T10892 CS-003 Free base CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3...
T10688 Casopitant mesylate Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of ant...
T13329L Vofopitant dihydrochloride Vofopitant dihydrochloride is a selective and orally available antagonist of tachykinin neurokinin 1(NK1) receptor(pKi of 9.5 and 10.6, in rat and human membran...
T13329 Vofopitant Vofopitant is potent antagonist of tachykinin NK1 receptor(pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively).
T16406 Orvepitant maleate Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitan...
TP1087 Substance P Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
Aprepitant
T1743CAS 170729-80-3
Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inh...
Fosaprepitant dimeglumine
T1790CAS 265121-04-8
Fosaprepitant Dimeglumine is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Up...
Rolapitant
T3716CAS 552292-08-7
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
Rolapitant hydrochloride
T3724CAS 914462-92-3
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor)...
Netupitant
T6905CAS 290297-26-6
Netupitant is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
Maropitant
T7209CAS 147116-67-4
Maropitant is a selective neurokinin (NK1) receptor antagonist.
Physalaemin
T19518CAS 2507-24-6
Physalaemin is a non-mammalian tachykinin.
CS-003 Free base
T10892CAS 191672-52-3
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3...
Casopitant mesylate
T10688CAS 414910-30-8
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of ant...
Vofopitant dihydrochloride
T13329LCAS 168266-51-1
Vofopitant dihydrochloride is a selective and orally available antagonist of tachykinin neurokinin 1(NK1) receptor(pKi of 9.5 and 10.6, in rat and human membran...
Vofopitant
T13329CAS 168266-90-8
Vofopitant is potent antagonist of tachykinin NK1 receptor(pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively).
Orvepitant maleate
T16406CAS 579475-24-4
Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitan...
Substance P
TP1087CAS 33507-63-0
Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.