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Cat No. | Product Name | Synonyms | Targets |
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TP2206 | [Leu31,Pro34]-Neuropeptide Y (porcine) | Neuropeptide Y Receptor | |
High affinity neuropeptide Y Y1 receptor agonist | |||
T23094 | NTNCB hydrochloride | Others , Neuropeptide Y Receptor | |
NTNCB hydrochloride is an antagonist of neuropeptide Y (NPY) Y5 receptor. | |||
TQ0286 | MK-0557 | Neuropeptide Y Receptor | |
MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM). | |||
T8963 | CYM2503 | Neuropeptide Y Receptor | |
CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by ... | |||
T10539 | BIBO3304 TFA | Neuropeptide Y Receptor | |
BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor). | |||
T17222 | Velneperit | S2367 | Neuropeptide Y Receptor |
Velneperit (S2367) is potent and selective neuropeptide Y (NPY) Y5 receptor under evaluating for treatment of obesity. | |||
T5587 | CGP71683 hydrochloride | CGP71683A | Neuropeptide Y Receptor |
CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes. | |||
TP1380 | Galanin (1-16), mouse, porcine, rat | Neuropeptide Y Receptor | |
Galanin (1-16), mouse, porcine, rat is a hippocampal galanin receptor agonist(Kd = 3 nM) with high biological activity on locus coeruleus neurons. | |||
T1997 | JNJ-31020028 | JNJ 31020028 | Neuropeptide Y Receptor |
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors. | |||
T5455 | HT-2157 | SNAP37889,SNAP-37889 | Neuropeptide Y Receptor |
HT-2157 (SNAP-37889) is a selective, high-affinity competitive antagonist of the galanin-3 receptor (Gal3), demonstrating effective inhibition of this target. | |||
T74350 | Neuropeptide Y Y1 receptor antagonist 1 | ||
Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, serves as a powerful antagonist against the neuropeptide Y Y1 receptor (Y1R), exhibiting a Kᵢ value of 0.19 nM [1]. It should be stored in condi... | |||
TP1059 | Peptide YY (PYY) (3-36), human | Peptide YY (3-36) | Neuropeptide Y Receptor |
Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) is a gut hormone peptide. Peptide YY (PYY) (3-36), human acts as a Y2 receptor agonist to reduce appetite. | |||
T8456 | GALNON | Neuropeptide Y Receptor | |
Galnon is a galanin receptor agonist, improves intrinsic cortical bone tissue properties | |||
T12895 | SHA 68 | Neuropeptide Y Receptor | |
SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively). | |||
T23087 | NPY 5RA972 | Neuropeptide Y Receptor | |
neuropeptide Y Y5 receptor antagonist | |||
TP1984L | [D-Trp34]-Neuropeptide Y Acetate | [D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base) | Neuropeptide Y Receptor |
[D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-... | |||
T21611L | BWX 46 Acetate | BWX 46 Acetate(172997-92-1 Free base) | Neuropeptide Y Receptor |
BWX 46 Acetate is a potent, highly selective neuropeptide Y (NPY) receptor agonist with IC50 of 0.5 nM. | |||
T23349 | SF 11 | Others | |
SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist with IC50 of 199 nM. Antidepressant-like activity | |||
TP1137L | Pancreatic Polypeptide (human) acetate | Neuropeptide Y Receptor | |
Pancreatic Polypeptide (human) acetate is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist. | |||
T15679 | L 152804 | Neuropeptide Y Receptor | |
L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice. | |||
T26801 | BIBP3226 | BIBP 3226,BIBP-3226 | |
BIBP3226 is a potent and selective antagonist for the Neuropeptide Y receptor Y1 and the neuropeptide FF receptor. | |||
T36447 | Neuropeptide Y 13-36 (porcine) | ||
Neuropeptide Y 13-36 (porcine) is a selective neuropeptide Y2 receptor agonist. | |||
T27345 | FMS586 | FMS-586,FMS 586 | |
FMS586 is a selective antagonist of neuropeptide Y Y5 receptor with oral activity. | |||
T23287 | S 25585 | Others | |
S 25585 is a neuropeptide Y (NPY) Y5 receptor antagonist. | |||
T22935 | LU AA33810 | Others | |
LU AA33810 is a neuropeptide Y (NPY) Y5 receptor antagonist. | |||
T36445 | Neuropeptide Y (3-36) (human, rat) | ||
Neuropeptide Y (3-36) (human, rat) is a metabolite of neuropeptide Y (NPY) generated by dipeptidyl peptidase-4 (DPP4). Known as a selective Y2 receptor agonist, Neuropeptide Y (3-36) (human, rat) effectively reduces the ... | |||
TP1081 | Neuropeptide Y (13-36), amide, human | Neuropeptide Y (13-36), human | |
Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist. | |||
T26008 | PYX 2 | PYX2,PYX-2 | |
PYX 2 is used as a neuropeptide Y receptor antagonist. | |||
T76355 | Neuropeptide Y (3-36) (porcine) | ||
Neuropeptide Y (3-36) (porcine) acts as an agonist for the Y2 subtype of the neuropeptide Y (NPY) receptor, effectively stimulating feeding behavior in rats. This compound exhibits high selectivity for the Y2 receptor co... | |||
T10921 | CYM 9484 | Others | |
CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with IC50 value of 19 nM. | |||
T10540 | BIBP3226 TFA | Others | |
BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF). | |||
T14572 | BIIE-0246 | AR-H 053591 | Others |
BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist. With an IC50 of 15 nM. | |||
T10514 | FR252384 | Others | |
FR252384 is an antagonist of the neuropeptide Y-Y5 receptor (IC50: 2.3 nM). | |||
T37528 | TBPC | ||
Positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Sh... | |||
T22608 | BMS 193885 | BMS193885 | Neuropeptide Y Receptor |
BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM. | |||
TP1985 | [Leu31,Pro34]-Neuropeptide Y(human,rat) | [Leu31,Pro34]-Neuropeptide Y (human, rat) | |
High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors. | |||
T75912 | [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA | ||
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA acts as a specific agonist for the neuropeptide Y Y1 receptor, while also activating receptors Y4 and Y5. This compound is known to elevate blood pressure in anesthetized rats ... | |||
T75911 | [D-Trp34]-Neuropeptide Y TFA | ||
[D-Trp34]-Neuropeptide Y TFA acts as a potent and selective agonist for the neuropeptide Y (NPY) Y5 receptor, demonstrating significantly lower potency at the NPY Y1, Y2, Y4, and Y6 receptors. It has been observed to sig... | |||
T69621 | BIIE-0246 HCl | ||
BIIE-0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor. BIIE-0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors. | |||
T76357 | Neuropeptide Y (18-36) (porcine) | ||
Neuropeptide Y (18-36) (porcine) acts as a competitive antagonist of the neuropeptide Y (NPY) cardiac receptor, effectively blocking the attachment of I-NPY to cardiac ventricular membranes. Its action is concentration-d... | |||
T41188 | BIBP 3226 trifluoroacetate | ||
BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1(NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Kivalues are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4... | |||
T36481 | BIIE 0246 hydrochloride | ||
Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo. | |||
T12623 | (R)-JNJ-31020028 | Others | |
(R)-JNJ-31020028 is a high affinity, selective brain penetrant antagonist of neuropeptide Y Y2 receptor(pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively). | |||
T75730 | [D-Arg25]-Neuropeptide Y (human) | ||
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY), a Y1 receptor selective agonist, plays a role in Alzheimer's disease (AD) and safeguards rat cortical neurons from β-Amyloid toxicity [1]. | |||
TP2022 | GR231118 | GR 231118 | |
Potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1, receptors respectively). Also a potent and selective NPY Y4 receptor agonist (pEC50 values are 6.0, 8.6 and 6.1 for rY2, hY4 and rY5 r... | |||
T74459 | Y1R probe-1 | ||
Compound 39, also known as Y1R probe-1, is a high-affinity fluorescent probe targeting the Neuropeptide Y Y1 Receptor, with potential applications in cancer research [1]. | |||
T76423 | Neuropeptide AF (cattle) | ||
Neuropeptide AF (cattle), an amidated octadecapeptide and RFamide neuropeptide, serves as a ligand for Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) with an EC50 of approximately... | |||
T75910 | GR231118 TFA | ||
GR231118 TFA, a neuropeptide Y C-terminus analogue, acts as a potent, competitive, and relatively selective antagonist at the human neuropeptide YY receptor, exhibiting a pKi of 10.4. It serves as a strong agonist at the... | |||
T15620 | JNJ-5207787 | Others | |
JNJ-5207787 is a penetrates the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. It is >100-fold selective versus human Y1, Y4, and Y5 receptors. JNJ-5207787 suppresses the binding of peptide YY with pIC50... | |||
TP1963 | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide | cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide | |
Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM)... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02809 | NPY2R Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Receptor for neuropeptide Y and peptide YY. | |||
TMPH-01767 | NPY2R Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY a... |