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Cat No. | Product Name | Synonyms | Targets |
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TP1310 | Neurotensin | Neurotensin Receptor | |
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. | |||
T7617 | Neurotensin(8-13) | Neurotensin(8-13)(3TFA) | Neurotensin Receptor |
Neurotensin(8-13)(3TFA) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. | |||
T16860 | SBI-553 | Neurotensin Receptor | |
SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM). | |||
TQ0086 | AF38469 | AF-38469 | Neurotensin Receptor |
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM). | |||
T9044 | SORT-PGRN interaction inhibitor 1 | Neurotensin Receptor | |
SORT-PGRN interaction inhibitor 1 is a potent sortilin-progranulin interaction inhibitor(IC50 of 2 μM). | |||
T11861 | LM11A-31 dihydrochloride | Others | |
LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni... | |||
T23386 | SR 142948 | Neurotensin Receptor | |
SR 142948 is a neurotensin (NT) receptor antagonist. | |||
T28217 | NTRC-844 | NTRC 844,NTRC844 | Neurotensin Receptor |
NTRC-844 is a selective rat neurotensin receptor type 2 (NTS2) antagonist that shows analgesic activity in animal models of pain. | |||
TP1085L | Neuromedin N acetate(92169-45-4 free base) | Neuromedin N (rat, mouse, porcine, canine) acetate | Dopamine Receptor |
Neuromedin N acetate(92169-45-4 free base) is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.Neuromedin N is a potent modulator of d... | |||
T37529 | TC NTR1 17 | ||
Non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35. Hershberger et ... | |||
T16358 | NTRC-824 | Others | |
NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM). | |||
T16034 | Meclinertant | SR 48692 | Others |
Meclinertant is an effective, selective, nonpeptide, and orally active neurotensin receptor 1 (NTS1) antagonist. Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization (pA2 : 8.13), in... | |||
T32700 | Levocabastine | Livostin,Bilina | |
Levocarbastine is a second-generation H1 receptor antagonist for allergic conjunctivitis. It also acts as a potent selective antagonist for the neurotensin receptor NTS2 and is the first drug to be used to characterize d... | |||
T75711 | Contulakin G | ||
Contulakin G, an O-glycosylated invertebrate neurotensin, serves as a weaker agonist for the neurotensin receptor. Additionally, it is recognized as a potent antinociceptive agent [1] [2]. | |||
T70271 | PD-149163 | ||
PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cogniti... | |||
T28845 | SR142948A HCl | SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride | |
SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It... | |||
T75868 | JMV 449 acetate | ||
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC 50 of 0.15 nM for inhibition of 125 I-neurotensin binding to neonatal mouse brain and an EC 50 of 1.9 nM in contracting the guinea-pig... | |||
TP2012 | JMV 449 | ||
Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hyp... | |||
T73677 | SR 142948 dihydrochloride | ||
SR 142948 dihydrochloride is a selective, orally active, non-peptide neurotensin receptor (NT) antagonist, featuring IC50 values of 1.19 nM, 0.32 nM, and 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, res... |
Cat No. | Product Name | Species | Expression System |
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TMPK-01162 | NTS1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the ... | |||
TMPK-00982 | NTS1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the ... | |||
TMPH-03081 | ACE2 Protein, Paguma larvata, Recombinant (hFc) | Paguma larvata | HEK293 |
Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin ... |