oxphos inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8500	VLX600		OXPHOS , Mitochondrial Metabolism , Autophagy
	VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.		OXPHOS , Mitochondrial Metabolism , Autophagy
T5337	IACS-010759	IACS-10759,IACS 10759,IACS10759	Apoptosis , Others , Mitochondrial Metabolism
	IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.		Apoptosis , Others , Mitochondrial Metabolism
T8841	IMT1	Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others , DNA/RNA Synthesis , Mitochondrial Metabolism
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.		Others , DNA/RNA Synthesis , Mitochondrial Metabolism
T8842	IMT1B	3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974	Others , DNA/RNA Synthesis
	IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it...		Others , DNA/RNA Synthesis
T6834	FCCP	Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone	ATPase , Mitochondrial Metabolism
	FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.		ATPase , Mitochondrial Metabolism
T7081	CCCP	Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone	Apoptosis , IκB/IKK , COX , Mitochondrial Metabolism , STING , IFNAR , Antibacterial
	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ...
T63136	DX3-213B		OXPHOS
	DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM. DX3-213B blocks ATP production (IC50: 11 nM) and inhibits the growth of MIA PaCa-2 cells (GI50: 11 nM)...		OXPHOS
T36420	IM-156 acetate	HL271 acetate
	IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-15...
T8532	IM156		OXPHOS
	IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in anima...		OXPHOS
T62890	OXPHOS-IN-1
	OXPHOS-IN-1 (compound 2) is an inhibitor of oxidative phosphorylation (OXPHOS) and inhibits the growth of MIA PaCa-2 cells (IC50: 2.34 μM) and BxPC-3 cells (IC50: 13.82 μM).
T62416	DX2-201
	DX2-201 is a potent and selective inhibitor of oxidative phosphorylation (OXPHOS) complex I (IC50: 312 nM) and exhibits anticancer activity.
T64004	DX3-234
	DX3-234 is an inhibitor of oxidative phosphorylation (OXPHOS). In a Pan02 homozygous model of pancreatic cancer, DX3-234 exhibits significant tumour suppressive activity.
T64108	DX3-235
	DX3-235 is an inhibitor of oxidative phosphorylation (OXPHOS). In galactose-containing media, DX3-235 inhibits complex I function and ATP production by nanomolar amounts and is significantly cytotoxic.
T27568	IACS-010759 hydrochloride	IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759
	IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NA...
T79477	SCAL-266		Mitochondrial Metabolism
	SCAL-266, a potent inhibitor of mitochondrial complex I (CI), exhibits an IC50 of 0.83 μM. This compound impairs mitochondrial function by blocking oxidative phosphorylation (OXPHOS), inhibiting oxygen consumption rate (...		Mitochondrial Metabolism
T74092	Cyanine5 alkyne
	Cyanine5 alkyne (Alkyne-Cy5), a fluorescent dye, labels azide proteins for analyzing post-translational modifications, such as glycosylation. Additionally, it serves as a mitochondrial OXPHOS inhibitor, curtailing the pr...
T79226	AMPK activator 11		Mitochondrial Metabolism
	AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative...		Mitochondrial Metabolism
T79476	SCAL-255		Mitochondrial Metabolism
	SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM. It impedes mitochondrial function by blocking oxygen consumption rate (OCR), inducing reactive oxygen species (R...		Mitochondrial Metabolism
T79285	TRAP1-IN-1		HSP
	TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and p...		HSP

Compounds

VLX600

T8500

Synonym:

Target: OXPHOS, Mitochondrial Metabolism, Autophagy

IACS-010759

T5337

Synonym: IACS-10759,IACS 10759,IACS10759

Target: Apoptosis, Others, Mitochondrial Metabolism

IMT1

T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

IMT1B

T8842

Synonym: 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974

Target: Others, DNA/RNA Synthesis

FCCP

T6834

Synonym: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone

Target: ATPase, Mitochondrial Metabolism

CCCP

T7081

Synonym: Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone

Target: Apoptosis, IκB/IKK, COX, Mitochondrial Metabolism, STING, IFNAR, Antibacterial

Synonym: HL271 acetate

IACS-010759 hydrochloride

T27568

Synonym: IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759

Target: Mitochondrial Metabolism

Target: Mitochondrial Metabolism

SCAL-255

T79476

Synonym:

Target: Mitochondrial Metabolism

Cat No.	Product Name	Synonyms	Targets
TN4171	Grossamide		NO Synthase
	Grossamide (GSE) Grossamide is a lignan amide derived from thioguanosine.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) i...		NO Synthase

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Compounds

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