T0012 |
Cinchonine |
Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local nar...
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T16339 |
Norverapamil hydrochloride |
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-gl...
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T2657 |
Elacridar |
Elacridar (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor. |
T2893 |
Muscone |
Muscone is an organic compound that is the primary contributor to the odor of musk. |
T2A2486 |
5,7,3',4',5'-Pentamethoxyflavone |
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adj...
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T2S0410 |
Euphorbia factor L1 |
1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 a...
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T2S0410 |
Euphorbia factor L1 |
1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 a...
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T2S2018 |
7-beta-Hydroxylathyrol |
7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp inhibition resulting in cytotoxic properties. |
T3002 |
Piperine |
Piperine (1-Piperoylpiperidine), a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders. |
T3392 |
Sinapine thiocyanate |
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)...
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T3868 |
Agnuside |
Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-gl...
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T4A2399 |
Cinobufotalin |
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide p...
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T6018 |
Zosuquidar 3HCl |
Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. |
T6287 |
Tariquidar |
Tariquidar(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. |
T8426 |
Encequidar |
Encequidar is a potent and selective P-glycoprotein inhibitor. |
TMA2270 |
Alisol F 24-acetate |
Alisol F 24-acetate is a natural product from Alisma plantago-aquatica Linn. |
TN1023 |
Miltirone |
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors. |
TN1039 |
Tamarixetin |
Tamarixetin has vasodilator effects in rat isolated vessels. Tamarixetin has cytotoxic against leukemia cells and in particular P-glycoprotein- overexpressing K...
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TN1048 |
Cnidilin |
Cnidilin has high BBB permeability and has pharmacokinetic potentials for the treatment of central nervous system diseases. |
TN1072 |
Lappaol A |
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also...
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TN1099 |
Dihydroevocarpine |
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is ...
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TN1421 |
Bacopaside II |
Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis. |
TN1425 |
Bacoside A3 |
Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS. |
TN1580 |
Dihydrodaidzein |
Dihydrodaidzein-producing bacteria might lead to clarification of some of the mechanisms regulating the production of equol by fecal microbiota. |
TN1610 |
Epimagnolin A |
Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal cong...
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TN1757 |
Hypophyllanthin |
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. |
TN2233 |
Spathulenol |
Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possi...
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TN2254 |
Taccalonolide A |
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is...
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TN2257 |
Tanshinone IIB |
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in ...
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TN2263 |
Tenacigenin B |
Standard reference |
TN2554 |
1-Monopalmitin |
1-Monopalmitin has dielectric properties. 1-Monopalmitin inhibits the P-glycoprotein activity in intestinal Caco-2 cells. |
TN2726 |
Jatrophane 5 |
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-T...
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TN2727 |
Jatrophane 2 |
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-fe...
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TN3937 |
ent-16alpha,17-Dihydroxyatisan-3-one |
ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lym...
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TN4410 |
Lappaol C |
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also...
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TN4411 |
Lappaol F |
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. La...
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TN4749 |
Pepluanin A |
Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated daun...
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TN4761 |
Phellamurin |
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensu...
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TN4819 |
(-)-Praeruptorin A |
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depe...
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TN5114 |
Taxinine |
Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. |
TN5118 |
Taxol C |
1. Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain. <br/> |
TN5124 |
Taxuspine X |
Taxuspine X may have p-glycoprotein inhibitory activity. |
TQ0043 |
Dofequidar |
Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR. |