Search Result

Search Results for " p-gp "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T12341	P-gp inhibitor 1		Others , P-gp
	P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).		Others , P-gp
T12340	P-gp modulator 1		Others
	P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator		Others
T21640	Talinolol		Adrenergic Receptor
	(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.		Adrenergic Receptor
T63608	P-gp inhibitor 5
	P-gp inhibitor 5 is a potent inhibitor of P-glycoprotein (P-gp), inhibiting P-gp by a factor of 2.5 and 3.0 at 1.25 μM and 2.5 μM, respectively. p-gp inhibitor 5 exhibits anti-proliferative effects on some cancer cells. ...
T79261	P-gp inhibitor 15
	P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123 efflux. Additionally, this compound enhances the inhibitory ef...
T8596	Ceefourin 1		MRP
	Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.		MRP
T63745	P-gp modulator 3
	P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.
T63032	P-gp modulator 2
	P-gp modulator 2 (Compound 27) is a potent competitive and metabotropic P-glycoprotein (P-gp) modulator.
T78974	P-gp inhibitor 13
	P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia research [1].
T72739	P-gp inhibitor 2
	P-gp Inhibitor 2 is a powerful P-glycoprotein (P-gp) inhibitor, effective in reversing Doxorubicin resistance with an IC50 of 0.22 µM in human colorectal carcinoma cells overexpressing P-gp (SW600 Ad300).
T72665	P-gp inhibitor 3
	P-gp Inhibitor 3, an effective P-glycoprotein (P-gp) inhibitor, activates P-gp ATPase to inhibit P-gp's efflux function. It demonstrates a relatively stronger multidrug resistance (MDR) reversal ability, thereby enhancin...
T72678	P-gp inhibitor 4
	P-gp inhibitor 4 is a selective P-glycoprotein modulator with an EC 50 of 94 nM. P-gp inhibitor 4 increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer...
T79353	P-gp/BCRP-IN-2
	P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). Additionally, it bolsters the anti-prolifera...
T8426	Encequidar	HM30181,HM30181A	P-gp
	Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.		P-gp
T63267	P-gp/BCRP-IN-1
	P-gp/BCRP-IN-1 (compound 19) is a relatively safe, orally active, and efficient inhibitor of the efflux transporters P-gp and BCRP. By inhibiting their efflux function, it reverses resistance and enhances the oral bioava...
T16561	Polyoxyethylene stearate	POES	Antibacterial , P-gp
	Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.		Antibacterial , P-gp
T11071	Dofequidar fumarate	MS-209	P-gp
	Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass...		P-gp
T6287	Tariquidar	XR9576	P-gp
	Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.		P-gp
T0351	Risperidone	Risperidal,R 64 766	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , P-gp
	Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T4059	Selamectin	UK-124114	Chloride channel , P-gp , Parasite
	Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...		Chloride channel , P-gp , Parasite
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T11578L	Encequidar mesylate	HM30181 mesylate,HM30181A mesylate	P-gp
	Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.		P-gp
T83923	Girard's Reagent P	Girard P hydrazine,GirP,GP
	Girard's Reagent P, a cationic hydrazine compound, serves as a derivatization agent for the quantification of glycans, oxysterols, and 5-methylcytosine derivatives.
T8389	Trifluoperazine	trifluoroperazine	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T0100L	Atazanavir	Zrivada,Reyataz,Latazanavir,BMS-232632	P450 , SARS-CoV , HIV Protease , P-gp
	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.		P450 , SARS-CoV , HIV Protease , P-gp
T20656	Verapamil	NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil	P450 , Calcium Channel , P-gp
	Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...		P450 , Calcium Channel , P-gp
T16339	Norverapamil hydrochloride	(±)-Norverapamil hydrochloride,D591 hydrochloride	Calcium Channel , P-gp , Drug Metabolite
	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.		Calcium Channel , P-gp , Drug Metabolite
T1010	Verapamil hydrochloride	Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450 , Calcium Channel , P-gp
	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.		P450 , Calcium Channel , P-gp
T1222	Trifluoperazine dihydrochloride	Trifluoperazine 2HCl,SKF5019,Urinox	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T0100	Atazanavir sulfate	BMS-232632,BMS-232632 sulfate	P450 , SARS-CoV , HIV Protease , P-gp
	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.		P450 , SARS-CoV , HIV Protease , P-gp
T2657	Elacridar	GW0918,GW120918,GF120918,GG918	BCRP , P-gp
	Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.		BCRP , P-gp
T6018	Zosuquidar trihydrochloride	Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.		P-gp
T72055	FM04		P-gp
	FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R...		P-gp
T64133L	Laniquidar TFA	Laniquidar TFA(197509-46-9 Free base),R101933	P-gp
	Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavailability and can be used to modulate the multidrug resistan...		P-gp
T2590	Vismodegib	Erivedge,GDC-0449,RG 3616	Hedgehog/Smoothened , ABC , Autophagy
	Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).		Hedgehog/Smoothened , ABC , Autophagy
T9173	HM-30181 mesylate monohydrate		P-gp
	HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.		P-gp
T77575	P-gb-IN-1		P-gp
	P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 s...		P-gp
T30260	AZD-5672	AZD 5672,AZD5672,UNII-61XQN688TW	HER , P-gp , CCR
	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheu...		HER , P-gp , CCR
T16026	MCI826		P-gp , LTR
	MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model of advanced asthma.		P-gp , LTR
T41231	GP 1a		Cannabinoid Receptor , PERK , Arrestin
	GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and incr...		Cannabinoid Receptor , PERK , Arrestin
T70489	Enerisant HCl		P450 , Histamine Receptor
	Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.		P450 , Histamine Receptor
T60009	YS-370		P-gp
	YS-370 is an orally active inhibitor of P-gp and shows moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance to paclitaxel and colchicine and exhibits stronger antitumor activity in combina...		P-gp
T3581	KS176		Potassium Channel , BCRP
	KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1.		Potassium Channel , BCRP
T19649	PF-06273340	PF 6273340,PF 06273340,PF6273340,PF-6273340	Trk receptor
	PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflu...		Trk receptor
T6931	PD0166285	PD-166285	Apoptosis , Wee1 , Chk
	PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.		Apoptosis , Wee1 , Chk
T27985	MC-70	MC70,MC 70
	MC-70 is a potent P-glycoprotein (P-gp) inhibitor (EC50 = 0.69 μM).
T67790	Biricodar dicitrate	VX 710,VX 710-3	NF-κB , AChR
	Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.		NF-κB , AChR
T13087	Tariquidar methanesulfonate, hydrate	XR9576 methanesulfonate, hydrate	Others
	Tariquidar methanesulfonate, hydrate is a potent and specific P-glycoprotein (P-gp) inhibitor(Kd of 5.1 nM).		Others
T11268	FD 12-9	Ac12Az9	Others
	FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively.		Others

Compounds

Target: Adrenergic Receptor

Synonym: HM30181,HM30181A

Polyoxyethylene stearate

T16561

Synonym: POES

Target: Antibacterial, P-gp

Synonym: Risperidal,R 64 766

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, P-gp

Selamectin

T4059

Synonym: UK-124114

Target: Chloride channel, P-gp, Parasite

Zamicastat

T13383

Synonym: BIA 5-1058

Target: BCRP, Hydroxylase, P-gp

Encequidar mesylate

T11578L

Synonym: HM30181 mesylate,HM30181A mesylate

Target: P-gp

Girard's Reagent P

T83923

Synonym: Girard P hydrazine,GirP,GP

Target:

Trifluoperazine

T8389

Synonym: trifluoroperazine

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Glibenclamide

T1634

Synonym: Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Atazanavir

T0100L

Synonym: Zrivada,Reyataz,Latazanavir,BMS-232632

Target: P450, SARS-CoV, HIV Protease, P-gp

Verapamil

T20656

Synonym: NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil

Target: P450, Calcium Channel, P-gp

Norverapamil hydrochloride

T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride

Target: Calcium Channel, P-gp, Drug Metabolite

Verapamil hydrochloride

T1010

Synonym: Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

Trifluoperazine dihydrochloride

T1222

Synonym: Trifluoperazine 2HCl,SKF5019,Urinox

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Atazanavir sulfate

T0100

Synonym: BMS-232632,BMS-232632 sulfate

Target: P450, SARS-CoV, HIV Protease, P-gp

Elacridar

T2657

Synonym: GW0918,GW120918,GF120918,GG918

Target: BCRP, P-gp

Zosuquidar trihydrochloride

T6018

Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride

Synonym: Laniquidar TFA(197509-46-9 Free base),R101933

Target: P-gp

Vismodegib

T2590

Synonym: Erivedge,GDC-0449,RG 3616

Target: Hedgehog/Smoothened, ABC, Autophagy

HM-30181 mesylate monohydrate

Synonym: AZD 5672,AZD5672,UNII-61XQN688TW

Target: HER, P-gp, CCR

Target: Cannabinoid Receptor, PERK, Arrestin

Enerisant HCl

T70489

Synonym:

Target: P450, Histamine Receptor

Target: Potassium Channel, BCRP

PF-06273340

T19649

Synonym: PF 6273340,PF 06273340,PF6273340,PF-6273340

Target: Apoptosis, Wee1, Chk

Synonym: VX 710,VX 710-3

Target: NF-κB, AChR

Tariquidar methanesulfonate, hydrate

T13087

Synonym: XR9576 methanesulfonate, hydrate

Cat No.	Product Name	Synonyms	Targets
TN4761	Phellamurin		P-gp
	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...		P-gp
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST
T2S0223	Isosinensetin	6-Demethoxynobiletin	Antioxidant , HIV Protease , Antibacterial , P-gp
	1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.		Antioxidant , HIV Protease , Antibacterial , P-gp
TJS1159	Chrysosplenetin	Chrysosptertin B	P450 , Ferroptosis , P-gp
	Chrysosplenetin is a metabolic inhibitor of artemisinin.		P450 , Ferroptosis , P-gp
T3002	Piperine	1-Piperoylpiperidine,Bioperine	P450 , Endogenous Metabolite , P-gp , Autophagy
	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.		P450 , Endogenous Metabolite , P-gp , Autophagy
T2S0271	Voacamine	Voacanginine	Cannabinoid Receptor , P-gp
	Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini...		Cannabinoid Receptor , P-gp
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T4034	Solamargine	Solamargin,δ-Solanigrine	Apoptosis , p38 MAPK , P-gp , STAT
	Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel...		Apoptosis , p38 MAPK , P-gp , STAT
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
T2799	(20S)-Protopanaxadiol	20-Epiprotopanaxadiol,20(S)-APPD	Apoptosis , Reactive Oxygen Species , P-gp
	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.		Apoptosis , Reactive Oxygen Species , P-gp
TN1757	Hypophyllanthin		Potassium Channel , Calcium Channel , P-gp
	Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.		Potassium Channel , Calcium Channel , P-gp
TN1525	Convallatoxin		NF-κB , P-gp , PPAR
	Convallatoxin is a natural product		NF-κB , P-gp , PPAR
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
TCS2336	Evodine		P-gp
	1. Evodine has antinociceptive activity.		P-gp
T19768	γ-Tocotrienol	gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol	Others
	γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.		Others
TN2062	Phyllanthin		NF-κB
	Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.		NF-κB
T2S2018	7beta-Hydroxylathyrol	7β-Hydroxylathyrol,7-Hydroxylathyrol,7-beta-Hydroxylathyrol	P-gp
	7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp inhibition resulting in cytotoxic properties.		P-gp
T3868	Agnuside	chasteberry oil	COX , Prostaglandin Receptor , P-gp
	Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at conce...		COX , Prostaglandin Receptor , P-gp
T6S0077	Byakangelicol		COX
	1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...		COX
T0012	Cinchonine	LA40221,(8R,9S)-Cinchonine	Apoptosis , P-gp , Parasite
	Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spi...		Apoptosis , P-gp , Parasite
T4A2399	Cinobufotalin		IL Receptor , Akt , MRP , P-gp
	Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent...		IL Receptor , Akt , MRP , P-gp
TN1918	Medicarpin		Apoptosis , BCL , ROS , JNK
	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of peak bone mass, and is devoid of uterine estrogenicity; in add...		Apoptosis , BCL , ROS , JNK
T75524	Mutabilol
	Mutabilol, also known as compound 1, is a natural product derived from the leaves of Plectranthus mutabilis that acts as a potent regulator of P-glycoprotein (P-gp). It has been shown to increase P-gp expression in NCI-H...
TN2726	Jatrophane 5		P-gp
	Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).		P-gp
T72735	Coleon-U-quinone
	Coleon-U-quinone, a potent P-gp (P-glycoprotein) inhibitor, effectively reduces the viability of cancer cells and increases the sensitivity of multidrug-resistant cancer cells to Doxorubicin [1].
TN1099	Dihydroevocarpine		MAO , P-gp , Antifection
	Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it s...		MAO , P-gp , Antifection
T13872	Roquefortine C		Others
	Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins		Others
TN2727	Jatrophane 2		P-gp , Antifection
	2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Ja...		P-gp , Antifection
T37810	6',7'-Epoxybergamottin
	6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, a...

Natural Products

Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp

Synonym: 6-Demethoxynobiletin

Target: Antioxidant, HIV Protease, Antibacterial, P-gp

Chrysosplenetin

TJS1159

Synonym: Chrysosptertin B

Target: P450, Ferroptosis, P-gp

Piperine

T3002

Synonym: 1-Piperoylpiperidine,Bioperine

Target: P450, Endogenous Metabolite, P-gp, Autophagy

Voacamine

T2S0271

Synonym: Voacanginine

Target: Cannabinoid Receptor, P-gp

Sinapine

T2S1200

Synonym:

Target: Antioxidant, P-gp, AChE

Solamargine

T4034

Synonym: Solamargin,δ-Solanigrine

Target: Apoptosis, p38 MAPK, P-gp, STAT

(20S)-Protopanaxadiol

T2799

Synonym: 20-Epiprotopanaxadiol,20(S)-APPD

Target: Apoptosis, Reactive Oxygen Species, P-gp

Hypophyllanthin

TN1757

Synonym:

Target: Potassium Channel, Calcium Channel, P-gp

Convallatoxin

TN1525

Synonym:

Target: NF-κB, P-gp, PPAR

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Synonym: gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol

7beta-Hydroxylathyrol

T2S2018

Synonym: 7β-Hydroxylathyrol,7-Hydroxylathyrol,7-beta-Hydroxylathyrol

Target: P-gp

Agnuside

T3868

Synonym: chasteberry oil

Target: COX, Prostaglandin Receptor, P-gp

Synonym: LA40221,(8R,9S)-Cinchonine

Target: Apoptosis, P-gp, Parasite

Cinobufotalin

T4A2399

Synonym:

Target: IL Receptor, Akt, MRP, P-gp

Medicarpin

TN1918

Synonym:

Target: Apoptosis, BCL, ROS, JNK

Target: MAO, P-gp, Antifection

Target: P-gp, Antifection

6',7'-Epoxybergamottin

T37810

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00665	Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His)	Human	HEK293
	Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 fam...
TMPJ-01145	ABCB5 Protein, Human, Recombinant (Trx)	Human	E. coli
	ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progen...
TMPY-01926	S100A10 Protein, Human, Recombinant (His)	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPK-01278	CD69 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	CLEC2C (CD69) is a membrane-bound, type II C-lectin receptor and acts as a costimulatory molecule for T cell activation and proliferation. It is involved in lymphocyte proliferation and functions as a signal transmitting...

Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His)

TMPY-00665

Species: Human

Expression System: HEK293

ABCB5 Protein, Human, Recombinant (Trx)

TMPJ-01145

Species: Human

Expression System: E. coli

S100A10 Protein, Human, Recombinant (His)

TMPY-01926

Species: Human

Expression System: E. coli

CD69 Protein, Cynomolgus, Recombinant (His)

TMPK-01278

Species: Cynomolgus

Expression System: HEK293