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P2 Receptor

Nucleotides if get released into the extracellular environment can lead to cell death or some other harmful cellular consequences. To avoid them it is required that they should be neutralized. Therefore P2 receptors come to work. Almost every cell type expresses P2 receptors. Purinergic signalling also has a pathophysiological role in several immune cells including calcium mobilization, actin polymerization, chemotaxis, the release of mediators, cell maturation, cytotoxicity, and cell death etc.Depending on the nature of the receptor they are found to be of two types:P2Y receptors and P2X receptors,P is for purinergic, P2 refers to ATP receptors, as opposed to P1 adenosine adenosine receptors. P2X receptors are ATP activated channels that allow the passage of ions across cell membranes. P2Y receptors are ATP activated G protein-coupled receptors (GPCRs) that initiate an intracellular chain of reactions.
Cat No. product name
T9786 Lu AF27139 Lu AF27139 是一种有效的选择性 P2X7 受体拮抗剂(人和大鼠的 IC50 分别为 12 和 2.4 nM,小鼠、人和大鼠的 Ki 分别为 22、54 和 13 nM)。 Lu AF27139 可用于中枢神经系统疾病研究。
T14366 AZ10606120 dihydrochloride AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1]. AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7...
T12568 PSB-12062 PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
T4743 Uridine 5′-diphosphoglucose disodium salt UDP-Glucose sodium salt is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It is an agonist of the P2Y14 receptor (EC50 =...
T2673 A 438079 hydrochloride A-438079 hydrochloride is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9.
T16399 Opiranserin Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T3639 A-804598 A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
T20731 Brilliant blue G-250 Brilliant Blue G is an antagonist of the P2X7 purinergic receptor.
T5099 Gefapixant Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
T14385 AZD9056 hydrochloride AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
T22518 5-BDBD 5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal ...
T8333 Aurintricarboxylic acid Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
TQ0002 A-317491 A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T8946 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
T0182L Clopidogrel hydrogen sulfate (S)-(+)-Clopidogrel hydrogensulfate, a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and ...
T6526 GW791343 trihydrochloride GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
T0362 Ticlopidine hydrochloride Ticlopidine hydrochloride is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
T4298 JNJ-47965567 JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X...
T4699 5-(N,N-Hexamethylene)-amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-...
T10466 BAY-1797 BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
T8635 CI 75300 CI 75300 targets the P2X purinoceptor 7 (human).
T2087 AF-353 AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T14844 BX430 BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
T4706 Uridine-5'-diphosphate disodium salt UDP is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstr...
T7805 GW791343 dihydrochloride GW791343 dihydrochloride is a P2X7 allosteric modulator.
T3690 A-740003 A 740003 is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropat...
T5036 Cangrelor tetrasodium Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
T1131 Ivermectin Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T7881 CTP disodium dihydrate CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
T6172 MRS 2578 MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
T9519 Eliapixant Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chron...
T21659 AZ 11645373 AZ 11645373 is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor.
T21059 Ticagrelor metabolite M5 Ticagrelor metabolite M5 is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster an...
T8582 1-[(5-methylisoxazol-3-yl)methyl]piperazine Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI) is a P2Y12 inhibitor.
T7423 Diquafosol tetrasodium Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium improves tear film stability...
T10207 A 438079 A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T10560 P2X3 antagonist 34 P2X3 antagonist 34 is a selective and orally active antagonist of P2X3 homotrimeric receptor (IC50s: 25 nM, 92 nM, and 126 nM for the human, rat, and guinea pig ...
T11177 Elinogrel Elinogrel can be given orally and intravenously and has a strong anti-platelet effect.Elinogrel is an effective, direct acting, competitive, reversible platelet ...
TP2226 BzATP triethylammonium salt BzATP triethylammonium salt is a P2X7 receptor agonist.
T6952 Prasugrel Hydrochloride Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome...
T4132 BPTU Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contrac...
T3536 AZD1283 AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
T5513 RO-3 RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T0182L2 (±) Clopidogrel hydrogen sulfate Clopidogrel, an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cere...
T0182 Clopidogrel Clopidogrel, a P2Y12 receptor antagonist, decreases platelet aggregation.
T0179 Ticagrelor Ticagrelor, produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The ...
T0230 Prasugrel Prasugrel is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANG...
T16572 Prasugrel (Maleic acid) Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. Prasugrel Maleic acid is a thienopy...
T16672 PSB-1114 tetrasodium PSB-1114 tetrasodium shows >50-fold selectivity versus the P2Y4 (EC50: 9.3 μM) and P2Y6 (EC50: 7.0 μM) receptors. PSB-1114 tetrasodium is an effective, enzymatic...
T14076 A 839977 A 839977 is a P2X7 selective antagonist and the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta[1]. It blocks...
Lu AF27139
T9786
Lu AF27139 是一种有效的选择性 P2X7 受体拮抗剂(人和大鼠的 IC50 分别为 12 和 2.4 nM,小鼠、人和大鼠的 Ki 分别为 22、54 和 13...
AZ10606120 dihydrochloride
T14366
AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1]. AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7...
PSB-12062
T12568
PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
Uridine 5′-diphosphoglucose disodium salt
T4743
UDP-Glucose sodium salt is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It is an agonist of the P2Y14 receptor (EC50 =...
A 438079 hydrochloride
T2673
A-438079 hydrochloride is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9.
Opiranserin
T16399
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
A-804598
T3639
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
Brilliant blue G-250
T20731
Brilliant Blue G is an antagonist of the P2X7 purinergic receptor.
Gefapixant
T5099
Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
AZD9056 hydrochloride
T14385
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
5-BDBD
T22518
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal...
Aurintricarboxylic acid
T8333
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
A-317491
TQ0002
A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
Indophagolin
T8946
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
Clopidogrel hydrogen sulfate
T0182L
(S)-(+)-Clopidogrel hydrogensulfate, a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and ...
GW791343 trihydrochloride
T6526
GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
Ticlopidine hydrochloride
T0362
Ticlopidine hydrochloride is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
JNJ-47965567
T4298
JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X...
5-(N,N-Hexamethylene)-amiloride
T4699
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
BAY-1797
T10466
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
CI 75300
T8635
CI 75300 targets the P2X purinoceptor 7 (human).
AF-353
T2087
AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
BX430
T14844
BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
Uridine-5'-diphosphate disodium salt
T4706
UDP is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstr...
GW791343 dihydrochloride
T7805
GW791343 dihydrochloride is a P2X7 allosteric modulator.
A-740003
T3690
A 740003 is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropat...
cangrelor tetrasodium
T5036
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
Ivermectin
T1131
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
CTP disodium dihydrate
T7881
CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
MRS 2578
T6172
MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
Eliapixant
T9519
Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chron...
AZ 11645373
T21659
AZ 11645373 is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor.
Ticagrelor metabolite M5
T21059
Ticagrelor metabolite M5 is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster an...
1-[(5-methylisoxazol-3-yl)methyl]piperazine
T8582
Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI) is a P2Y12 inhibitor.
Diquafosol tetrasodium
T7423
Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium improves tear film stability...
A 438079
T10207
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
P2X3 antagonist 34
T10560
P2X3 antagonist 34 is a selective and orally active antagonist of P2X3 homotrimeric receptor (IC50s: 25 nM, 92 nM, and 126 nM for the human, rat, and guinea pig ...
Elinogrel
T11177
Elinogrel can be given orally and intravenously and has a strong anti-platelet effect.Elinogrel is an effective, direct acting, competitive, reversible platelet ...
BzATP triethylammonium salt
TP2226
BzATP triethylammonium salt is a P2X7 receptor agonist.
Prasugrel Hydrochloride
T6952
Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome...
BPTU
T4132
Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contra...
AZD1283
T3536
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
RO-3
T5513
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
(±) Clopidogrel hydrogen sulfate
T0182L2
Clopidogrel, an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cere...
Clopidogrel
T0182
Clopidogrel, a P2Y12 receptor antagonist, decreases platelet aggregation.
Ticagrelor
T0179
Ticagrelor, produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The ...
Prasugrel
T0230
Prasugrel is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANG...
Prasugrel (Maleic acid)
T16572
Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. Prasugrel Maleic acid is a thienopy...
PSB-1114 tetrasodium
T16672
PSB-1114 tetrasodium shows >50-fold selectivity versus the P2Y4 (EC50: 9.3 μM) and P2Y6 (EC50: 7.0 μM) receptors. PSB-1114 tetrasodium is an effective, enzymat...
A 839977
T14076
A 839977 is a P2X7 selective antagonist and the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta[1]. It blocks...
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