T23549 |
YM 511
|
148869-05-0
|
100%
|
|
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively...
|
T1011 |
Itraconazole
|
84625-61-6
|
100%
|
|
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
|
T1704 |
Diosmetin
|
520-34-3
|
100%
|
|
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.
|
T0765 |
Fomepizole
|
7554-65-6
|
100%
|
|
Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competiti...
|
T3797 |
Isosilybin
|
72581-71-6
|
100%
|
|
Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patien...
|
TN1724 |
Harmalol hydrochloride
|
6028-07-5
|
100%
|
|
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is th...
|
T7725 |
Albaconazole
|
187949-02-6
|
100%
|
|
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, s...
|
T1597 |
Proadifen hydrochloride
|
62-68-0
|
100%
|
|
Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.
|
T0179 |
Ticagrelor
|
274693-27-5
|
100%
|
|
Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic ...
|
T1274 |
Benzbromarone
|
3562-84-3
|
100%
|
|
Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.
|
T10335 |
Antihistamine-1
|
1186430-60-3
|
100%
|
|
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 ...
|
T9328 |
Ellagic Acid Dihydrate
|
133039-73-3
|
|
|
Ellagic Acid Dihydrate inhibit the CYP1A1-dependent activation of benzo[a]pyrene.
|
T8728 |
DMU-2139
|
104890-70-2
|
|
|
DMU2139 is a specific CYP1B1 inhibitor (CYP1B1 and CYP1A1 with IC50 of 9 nM and 795 nM, respectively).
|
T8079 |
α-Terpinyl acetate
|
80-26-2
|
|
|
α-Terpinyl acetate is a natural compound found in several essential oils, is a flavouring agent.
|
T8182L |
Guan-fu base A hydrochloride(1394-48-5 free base)
|
618094-85-2
|
|
|
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monke...
|
T5582 |
β-Apo-8'-carotenal
|
1107-26-2
|
|
|
β-Apo-8'-carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressin...
|
T8182 |
Guanfu base A
|
1394-48-5
|
98%
|
|
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
|
T4567 |
Sulfaphenazole
|
526-08-9
|
98%
|
|
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CY...
|
TN6848 |
Piperonylic acid
|
94-53-1
|
98%
|
|
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinna...
|
T19783 |
Dehydroabiethylamine
|
1446-61-3
|
98%
|
|
Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular ch...
|