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P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T23549 YM 511 148869-05-0 100%
YM 511
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively...
T1011 Itraconazole 84625-61-6 100%
Itraconazole
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T1704 Diosmetin 520-34-3 100%
Diosmetin
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.
T0765 Fomepizole 7554-65-6 100%
Fomepizole
Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competiti...
T3797 Isosilybin 72581-71-6 100%
Isosilybin
Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patien...
TN1724 Harmalol hydrochloride 6028-07-5 100%
Harmalol hydrochloride
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is th...
T7725 Albaconazole 187949-02-6 100%
Albaconazole
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, s...
T1597 Proadifen hydrochloride 62-68-0 100%
Proadifen hydrochloride
Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.
T0179 Ticagrelor 274693-27-5 100%
Ticagrelor
Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic ...
T1274 Benzbromarone 3562-84-3 100%
Benzbromarone
Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.
T10335 Antihistamine-1 1186430-60-3 100%
Antihistamine-1
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 ...
T9328 Ellagic Acid Dihydrate 133039-73-3
Ellagic Acid Dihydrate
Ellagic Acid Dihydrate inhibit the CYP1A1-dependent activation of benzo[a]pyrene.
T8728 DMU-2139 104890-70-2
DMU-2139
DMU2139 is a specific CYP1B1 inhibitor (CYP1B1 and CYP1A1 with IC50 of 9 nM and 795 nM, respectively).
T8079 α-​Terpinyl acetate 80-26-2
α-​Terpinyl acetate
α-​Terpinyl acetate is a natural compound found in several essential oils, is a flavouring agent.
T8182L Guan-fu base A hydrochloride(1394-48-5 free base) 618094-85-2
Guan-fu base A hydrochloride(1394-48-5 free base)
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monke...
T5582 β-​Apo-​8'-​carotenal 1107-26-2
β-​Apo-​8'-​carotenal
β-​Apo-​8'-​carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressin...
T8182 Guanfu base A 1394-48-5 98%
Guanfu base A
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T4567 Sulfaphenazole 526-08-9 98%
Sulfaphenazole
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CY...
TN6848 Piperonylic acid 94-53-1 98%
Piperonylic acid
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinna...
T19783 Dehydroabiethylamine 1446-61-3 98%
Dehydroabiethylamine
Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular ch...
YM 511
T23549
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively...
Itraconazole
T1011
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Diosmetin
T1704
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.
Fomepizole
T0765
Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competiti...
Isosilybin
T3797
Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patien...
Harmalol hydrochloride
TN1724
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is th...
Albaconazole
T7725
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, s...
Proadifen hydrochloride
T1597
Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.
Ticagrelor
T0179
Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic ...
Benzbromarone
T1274
Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.
Antihistamine-1
T10335
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 ...
Ellagic Acid Dihydrate
T9328
Ellagic Acid Dihydrate inhibit the CYP1A1-dependent activation of benzo[a]pyrene.
DMU-2139
T8728
DMU2139 is a specific CYP1B1 inhibitor (CYP1B1 and CYP1A1 with IC50 of 9 nM and 795 nM, respectively).
α-​Terpinyl acetate
T8079
α-​Terpinyl acetate is a natural compound found in several essential oils, is a flavouring agent.
Guan-fu base A hydrochloride(1394-48-5 free base)
T8182L
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monke...
β-​Apo-​8'-​carotenal
T5582
β-​Apo-​8'-​carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressin...
Guanfu base A
T8182
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
Sulfaphenazole
T4567
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CY...
Piperonylic acid
TN6848
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinna...
Dehydroabiethylamine
T19783
Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular ch...
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TargetMol