P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
TN1343	8-Geranyloxypsoralen	7437-55-0	99.87%
TN1343	8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arter...
T3401	Ginsenoside F1	53963-43-2	99.86%
T3401	Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a ...
T5S2360	Corydaline	518-69-4	99.86%
T5S2360	1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric ...
T8182	Guanfu base A	1394-48-5	99.85%
T8182	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T8729	3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one	1031063-36-1	99.84%
T8729	DMU2105 is a specific CYP1B1 inhibitor(CYP1B1 and CYP1A1 with IC50 of 10 nM and 742 nM, respectively)
T10632	Bucolome	841-73-6	99.83%
T10632	Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.
T2143	Bergapten	484-20-8	99.83%
T2143	Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.
T7088	Diflubenzuron	35367-38-5	99.83%
T7088	Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also be...
T6215	Abiraterone Acetate	154229-18-2	99.83%
T6215	Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of me...
T3355	Naloxegol oxalate	1354744-91-4	99.82%
T3355	Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
T2770	Gentiopicroside	20831-76-9	99.8%
T2770	Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki ...
T1010	Verapamil hydrochloride	152-11-4	99.79%
T1010	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T21548	PF-4981517	1390637-82-7	99.77%
T21548	PF-4981517 (CYP3cide) is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 μM,17 μM...
T3411	Curdione	13657-68-6	99.76%
T3411	Curdione ((+)-Curdione) inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Cu...
T0100L	Atazanavir	198904-31-3	99.76%
T0100L	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T72501	CYP4A11/CYP4F2-IN-1	502654-40-2	99.75%
T72501	CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebro...
T6050	TAK-700	426219-18-3	99.75%
T6050	TAK-700 (Orteronel) (Orteronel) is a potent and highly selective human 17, 20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs...
T3736	Olivetol	500-66-3	99.74%
T3736	Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in...
T3696	Polygalaxanthone III	162857-78-5	99.74%
T3696	Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
T11218	ε-Viniferin	62218-08-0	99.73%
T11218	ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1...