P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
TN1691	Glabrol	59870-65-4	99.72%
TN1691	Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T1650	Chlorzoxazone	95-25-0	99.72%
T1650	Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
T15641	K777	233277-99-1	99.71%
T15641	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 a...
T117521	7-BFC	220001-53-6	99.71%
T117521	7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) is a coumarin-like fluorescent substrate that serves as a biomarker for cytochrome P 450 and can be used to study...
T5715	(E)-Flavokawain A	37951-13-6	99.7%
T5715	(E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-depende...
T4567	Sulfaphenazole	526-08-9	99.67%
T4567	Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CY...
T0100	Atazanavir sulfate	229975-97-7	99.67%
T0100	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with ...
T70489	Enerisant HCl	1152749-07-9	99.66%
T70489	Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins....
T2175	Apigenin	520-36-5	99.66%
T2175	Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for i...
T3811	Ginsenoside C-K	39262-14-1	99.65%
T3811	Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
T21818	Pregnenolone Carbonitrile	1434-54-4	99.64%
T21818	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.
T9113	Myristicin	607-91-0	99.63%
T9113	Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
TQ0296L	N-Nornuciferine hydrochloride(4846-19-9 free base)	TQ0296L	99.63%
TQ0296L	N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3...
T6S0630	Hypaconitine	6900-87-4	99.63%
T6S0630	Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T6246	Cobicistat	1004316-88-4	99.62%
T6246	Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, ...
T0679	Ketoconazole	65277-42-1	99.62%
T0679	Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T27918	LY 43578	26766-35-8	99.62%
T27918	LY 43578 is an orally active aromatase inhibitor. LY43578 could inhibit O-demethylation of P-450-dependent p-nitroanisole and N-demethylation of ethylmorphine (I...
T22254	Alflutinib	1869057-83-9	99.61%
T22254	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.
T3698	Alpha-Asarone	2883-98-9	99.59%
T3698	alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.
T7056	Dronedarone	141626-36-0	99.58%
T7056	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.