P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T6509	Galeterone	851983-85-2	99.57%
T6509	Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galetero...
T22391	Omeprazole Sodium	95510-70-6	99.57%
T22391	Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibit...
TN1078	Seneciphylline	480-81-9	99.53%
TN1078	Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significa...
T20656	Verapamil	52-53-9	99.53%
T20656	Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies ab...
T2944	Danshensu sodium salt	67920-52-9	99.52%
T2944	Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced...
TN1023	Miltirone	27210-57-7	99.51%
TN1023	Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
T2S0663	Humantenmine	82354-38-9	99.51%
T2S0663	1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities.
T0182L	Clopidogrel hydrogen sulfate	120202-66-6	99.51%
T0182L	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets ...
T5786	TETRAHYDROPIPERINE	23434-88-0	99.51%
T5786	Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T37826	CAY10462	502656-68-0	99.49%
T37826	CAY10462 (CTK8E8405) is an effective and selective inhibitor of the 20-HETE synthase CYP4A11 with an IC50 of 8.8 nM. CAY10462 exhibits nearly 200 times less pote...
T11991	Mefentrifluconazole	1417782-03-6	99.45%
T11991	Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.9...
T3585	TMS	24144-92-1	99.42%
T3585	TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
T5778	5,7-DIMETHOXYFLAVONE	21392-57-4	99.41%
T5778	5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.
T6030	XL388	1251156-08-7	99.39%
T6030	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
T13600	CDD3505	173865-33-3	99.39%
T13600	CDD3505 (4-nitro-1-trityl-1H-imidazole) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.
T3886	Rosavin	84954-92-7	99.38%
T3886	Rosavin (Rosavidin) has antidepressant and anxiolytic actions, helps balance all the neurotransmitters.
T11847L	Liarozole	115575-11-6	99.38%
T11847L	Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of ar...
T3735	Tetrahydrocurcumin	36062-04-1	99.37%
T3735	Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.
T21507	7-Ethoxyresorufin	5725-91-7	99.35%
T21507	7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
T6S1917	Schisandrol B	58546-54-6	99.32%
T6S1917	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated...