P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T12171	Nampt-IN-5	2380013-17-0	99.3%
T12171	Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
T1491	Atovaquone	95233-18-4	99.28%
T1491	Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
T6260	AMG-208	1002304-34-8	99.27%
T6260	AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.
TP1313L	Cecropin B acetate		99.27%
TP1313L	Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA se...
T3669	Curcumenol	19431-84-6	99.26%
T3669	Curcumenol ((+)-Curcumenol), one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol ...
T2840	Phloracetophenone	480-66-0	99.26%
T2840	Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of...
T77627	Opevesostat	2231294-96-3	99.25%
T77627	Opevesostat (ODM-208) is an inhibitor of lyase (CYP11A1) (the enzyme cleavage cholesterol side chain).
TN1011	Rhodionin	85571-15-9	99.24%
TN1011	Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
T3417	Amentoflavone	1617-53-4	99.22%
T3417	Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for ...
T11680	Isoasatone A	67451-73-4	99.21%
T11680	Isoasatone A is a natural product isolated from the plant Heterotropa takaoi M., with anti-insect activity.
T10923	CYP17-IN-1	2093317-51-0	99.17%
T10923	CYP17-IN-1 is an effective oral inhibitor of CYP17 that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.
T2761	Naringin dihydrochalcone	18916-17-1	99.16%
T2761	Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
T2878	Ginsenoside Rd	52705-93-8	99.13%
T2878	Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T9043	AS1810722	909561-15-5	99.13%
T9043	AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhi...
T0865	Ranitidine Hydrochloride	66357-59-3	99.13%
T0865	Ranitidine Hydrochloride (AH19065) is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversibl...
T0293	Metyrapone	54-36-4	99.12%
T0293	Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the ...
T3610	Ranitidine	66357-35-5	99.1%
T3610	Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestina...
T35716	N-desmethyl Olanzapine	161696-76-0	99.1%
T35716	N-desmethyl Olanzapine is a metabolite of the atypical antipsychotic compound Olanzapinec, which is formed through the oxidative metabolism of olanzapine by the ...
T16412	Oteseconazole	1340593-59-0	99.07%
T16412	Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Ca...
T37825	CAY10434	769917-29-5	99.07%
T37825	CAY10434 is an active inhibitor of CYP4A hydroxylase with an IC50 value of 8.8 nM in human kidney microsomal test. The maximum contractile value (Emax) of CAY 10...