PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.

Cat. No.	Product name	CAS No.	Purity
TN3443	Aristolactam AII	53948-07-5	98%
TN3443	Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN5045	Spiradine F	21040-64-2	98%
TN5045	Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
TN1815	Kadsulignan L	163660-06-8	98%
TN1815	Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
TN4088	Futoenone	19913-01-0	98%
TN4088	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
TN3520	Bisdethiobis(methylthio)gliotoxin	74149-38-5	98%
TN3520	Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN4181	Hancinone C	111843-10-8	98%
TN4181	Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN4660	Niranthin	50656-77-4	99.8%
TN4660	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
TN2329	Zingiberen newsaponin	91653-50-8	99.75%
TN2329	Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
T6242	Rupatadine Fumarate	182349-12-8	99.64%
T6242	Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
TN1643	Ferulamide	61012-31-5	99.45%
TN1643	Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.
T10159	48740 RP	93363-11-2	99.4%
T10159	48740 RP (RP 55779) is an antagonist of platelet-activating factor.
T2751	Ginkgolide B	15291-77-7	99.39%
T2751	Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
TN2322	Yangambin	13060-14-5	98.02%
TN2322	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peri...
T17178	Tulopafant	116289-53-3	98%
T17178	Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
T14007	PAF-AN-1	115621-84-6	98%
T14007	PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.
TN3831	(-)-Denudatin B	87402-88-8	98%
TN3831	(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoi...
TN1271	Scutellarein tetramethyl ether	1168-42-9	98%
TN1271	Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is extracted from Siam weeds and exhibits anti-inflammatory activity through NF-κB pathway.