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Metabolism PAI-1

PAI-1

Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis,PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
Cat No. product name
T2030 Tiplaxtinin Tiplaxtinin(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
T4255 TM5275 sodium TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T4254 TM5441 TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T3899 Calceolarioside B Calceolarioside B displays inhibition of aromatase. Calceolarioside B displays inhibition of human recombinant PKCalpha.
T4S0592 Toddalolactone anti-inflammatory and analgesic.
Tiplaxtinin
T2030CAS 393105-53-8
Tiplaxtinin(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
TM5275 sodium
T4255CAS 1103926-82-4
TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
TM5441
T4254CAS 1190221-43-2
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
Calceolarioside B
T3899CAS 105471-98-5
Calceolarioside B displays inhibition of aromatase. Calceolarioside B displays inhibition of human recombinant PKCalpha.
Toddalolactone
T4S0592CAS 483-90-9
anti-inflammatory and analgesic.