TN1663 |
Ganoderic acid DM
|
173075-45-1
|
98%
|
|
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
|
TN4932 |
Sageone
|
142546-15-4
|
98%
|
|
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
|
T11992 |
Mefuparib hydrochloride
|
1449746-00-2
|
98%
|
|
Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, su...
|
T78787 |
PARP-1/2-IN-2
|
|
98%
|
|
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair ...
|
T79026 |
Tankyrase-IN-5
|
1460285-69-1
|
98%
|
|
Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory concentr...
|
T79265 |
Antitumor agent-104
|
2245272-16-4
|
98%
|
|
Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme a...
|
T79330 |
PARP-1-IN-13
|
|
98%
|
|
PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand break...
|
T79405 |
PARP1-IN-15
|
|
98%
|
|
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhi...
|
T79593 |
PARP1-IN-14
|
2098639-70-2
|
98%
|
|
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on ...
|
T79647 |
VEGFR/PARP-IN-1
|
|
98%
|
|
VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways,...
|
T79667 |
YCH1899
|
|
98%
|
|
YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM. It shows marked antiproliferative efficac...
|
T79853 |
Lerzeparib
|
2459693-01-5
|
98%
|
|
Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].
|
T81249 |
Ru3
|
|
98%
|
|
Ru3 is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor that prompts apoptosis in MCF-7 cells through various mechanisms, including DNA damage induction, inhibi...
|
T81541 |
PARP7-IN-16
|
2435657-10-4
|
98%
|
|
PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively. It ha...
|
T81542 |
PARP7-IN-15
|
2819998-97-3
|
98%
|
|
PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].
|
T81543 |
PARP1-IN-17
|
|
98%
|
|
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis. It exhibits ...
|
T81544 |
PARP1-IN-16
|
|
98%
|
|
PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM. It possesses the capability to halt the cell cycle at the S p...
|
TN1642 |
Ferruginol
|
514-62-5
|
98%
|
|
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
TN2511 |
Britannilactone diacetate
|
1286694-67-4
|
98%
|
|
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
|