T60019 |
VPC-70063
|
13571-44-3
|
99.93%
|
|
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inh...
|
T6942 |
Picolinamide
|
1452-77-3
|
99.92%
|
|
Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
|
T6768 |
AZ6102
|
1645286-75-4
|
99.91%
|
|
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 c...
|
TN1854 |
Lasiodin
|
28957-08-6
|
99.90%
|
|
Lasiodin (Lasiokaurin) is a diterpene compound from the plant Camellia sinensis that inhibits the proliferation of NPC cells. Lasiodin has antioxidant, antitumor...
|
T3015 |
Olaparib
|
763113-22-0
|
99.89%
|
|
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is sel...
|
T4463 |
Rucaparib
|
283173-50-2
|
99.89%
|
|
Rucaparib (PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
|
T11143 |
EB-47
|
366454-36-6
|
99.86%
|
|
EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 va...
|
T3353 |
Niraparib hydrochloride
|
1038915-64-8
|
99.85%
|
|
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochl...
|
T6329 |
3-Aminobenzamide
|
3544-24-9
|
99.84%
|
|
3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion...
|
T22749 |
DR2313
|
284028-90-6
|
99.84%
|
|
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.
|
T40834 |
5-Hydroxymethyl-2'-deoxycytidine
|
7226-77-9
|
99.8%
|
|
5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, re...
|
T16807 |
Rucaparib monocamsylate
|
1859053-21-6
|
99.8%
|
|
Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP do...
|
TN5263 |
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
|
569-83-5
|
99.79%
|
|
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with...
|
T2S2362 |
Dehydrocorydaline nitrate
|
13005-09-9
|
99.79%
|
|
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
|
T2591 |
Veliparib
|
912444-00-9
|
99.76%
|
|
Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
|
T5399 |
GeA-69
|
2143475-98-1
|
99.75%
|
|
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
|
TN2329 |
Zingiberen newsaponin
|
91653-50-8
|
99.75%
|
|
Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
|
T61932 |
Nesuparib
|
2055357-64-5
|
99.71%
|
|
Nesuparib (JPI-547/OCN-201) is a potent PARP inhibitor with inhibitory effects on PARP and TNKS1.Nesuparib has antitumor activity and can be used in the treatmen...
|
T73007 |
PARP10-IN-2
|
1042780-52-8
|
99.68%
|
|
PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and P...
|
T15639 |
K-756
|
130017-40-2
|
99.68%
|
|
K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectivel...
|