PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Cat. No.	Product name	CAS No.	Purity
T2591	Veliparib	912444-00-9	99.76%
T2591	Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
T5399	GeA-69	2143475-98-1	99.75%
T5399	GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
TN2329	Zingiberen newsaponin	91653-50-8	99.75%
TN2329	Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
TN1153	Polyporenic acid C	465-18-9	99.71%
TN1153	Polyporenic acid C shows inhibitory activity against human collagenase.
T61932	Nesuparib	2055357-64-5	99.71%
T61932	Nesuparib (JPI-547/OCN-201) is a potent PARP inhibitor with inhibitory effects on PARP and TNKS1.Nesuparib has antitumor activity and can be used in the treatmen...
T73007	PARP10-IN-2	1042780-52-8	99.68%
T73007	PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and P...
T15639	K-756	130017-40-2	99.68%
T15639	K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectivel...
T6780	Benzamide	55-21-0	99.64%
T6780	Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
T9113	Myristicin	607-91-0	99.63%
T9113	Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
T7896	BYK204165	1104546-89-5	99.61%
T7896	BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)
T3062	WIKI4	838818-26-1	99.6%
T3062	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T12365	PARP/PI3K-IN-1	2337386-47-5	99.59%
T12365	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antipr...
T3649	BGP-15	66611-37-8	99.59%
T3649	BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
T16761	RK-287107	2171386-10-8	99.59%
T16761	RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).
T3261	NVP-TNKS656	1419949-20-4	99.55%
T3261	NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor.
T67932	PARP10-IN-3	2225800-19-9	99.54%
T67932	PARP10-IN-3 is a potent and selective mono-Adp-ribotransferase PARP10 inhibitor that inhibits human PARP10 (IC50:480 nM). PARP10-IN-3 also inhibited human PARP2 ...
T5058	Pamiparib	1446261-44-4	99.53%
T5058	Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP...
T22988	MK-4827 Racemate	1038915-75-1	99.47%
T22988	MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3...
T60039	KSQ-4279	2446480-97-1	99.43%
T60039	KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovar...
T7042	1,5-Isoquinolinediol	5154-02-9	99.43%
T7042	1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes wi...