T10481L |
BAY 73-6691
|
794568-92-6
|
98%
|
|
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
|
T13232 |
TyK2-IN-2
|
2098466-94-3
|
98%
|
|
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
|
T38108 |
Fulvic Acid
|
479-66-3
|
98%
|
|
Fulvic Acid is a natural product of humus produced by microorganisms in soil, sediment or aquatic environments. Fulvic acid is a phenolic acid and fungal metabol...
|
T15766 |
Lirimilast
|
329306-27-6
|
98%
|
|
Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties...
|
TN1843 |
Kushenol K
|
101236-49-1
|
98%
|
|
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
|
T16976 |
TAK-915
|
1476727-50-0
|
98%
|
|
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
|
T10416 |
Autotaxin-IN-4
|
2156655-86-4
|
98%
|
|
Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
|
T10417 |
Autotaxin-IN-5
|
2156655-99-9
|
98%
|
|
Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
|
T15640 |
K134
|
189362-06-9
|
98%
|
|
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.
|
T16272 |
Naproxen etemesil
|
385800-16-8
|
98%
|
|
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naprox...
|
T10994L2 |
Deltasonamide 2 (TFA)
|
2235358-74-2
|
98%
|
|
Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
|
T10350 |
Apremilast-d5
|
1258597-47-5
|
98%
|
|
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α rele...
|
T9805 |
BAY 2666605
|
2275774-60-0
|
99.98%
|
|
BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.
|
T0480 |
Doxofylline
|
69975-86-6
|
99.98%
|
|
Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofy...
|
TN2159 |
Robustine
|
2255-50-7
|
99.97%
|
|
Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro.
|
T0080 |
Trapidil
|
15421-84-8
|
99.96%
|
|
Trapidil (Avantrin) is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients wit...
|
T2205 |
Acefylline
|
652-37-9
|
99.95%
|
|
Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhyd...
|
T1681 |
Aminophylline
|
317-34-0
|
99.94%
|
|
Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
|
T1096 |
Milrinone
|
78415-72-2
|
99.93%
|
|
Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.
|
TN6120 |
Nauclefine
|
57103-51-2
|
99.92%
|
|
Nauclefine (Parvine) is a plant indole alkaloid natural product and induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. Nauclef...
|