PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T2137	Ibudilast	50847-11-5	99.9%
T2137	Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.
T4097	Vardenafil hydrochloride trihydrate	330808-88-3	99.89%
T4097	Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
T5106	BRL-50481	433695-36-4	99.89%
T5106	BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.
T0625	Theobromine	83-67-0	99.89%
T0625	Theobromine (3,7-Dimethylxanthine), a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
T10410	ATX inhibitor 1	2225892-70-4	99.88%
T10410	ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).
T0096	Vardenafil	224785-90-4	99.88%
T0096	Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
T6042	[11C]MP 10	1292799-56-4	99.87%
T6042	[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.
T5033	Olprinone	106730-54-5	99.87%
T5033	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflam...
T0462	Cilostazol	73963-72-1	99.87%
T0462	Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
T8405	Vardenafil hydrochloride	224785-91-5	99.86%
T8405	Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes
T1265	Amrinone	60719-84-8	99.86%
T1265	Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
T8787	Drotaverine hydrochloride	985-12-6	99.85%
T8787	Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during...
T16079	Mirodenafil	862189-95-5	99.85%
T16079	Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
T27596	Imazodan hydrochloride	89198-09-4	99.84%
T27596	Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.
T12103	MR-L2	2374703-19-0	99.84%
T12103	MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
T7954	YM976	191219-80-4	99.84%
T7954	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)
T1708	Pimobendan	74150-27-9	99.84%
T1708	Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).
T67815	Uk-50001	857900-47-1	99.83%
T67815	uk-50001 is a phosphodiesterase (PDE) 4 inhibitor that can be used for many diseases, especially inflammation, allergies, respiratory diseases, disorders and con...
T6S2115	Ginkgolide J	107438-79-9	99.83%
T6S2115	Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippoca...
T8919	Homo Sildenafil	642928-07-2	99.82%
T8919	Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.