PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T12315	OR-1896	220246-81-1	99.51%
T12315	OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator.
T25829	Mopidamol	13665-88-8	99.51%
T25829	Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental d...
T31101	CRT0273750	1979939-16-6	99.49%
T31101	CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.
T1618	Dipyridamole	58-32-2	99.47%
T1618	Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
T3631	PF-8380	1144035-53-9	99.45%
T3631	PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysopho...
T27475	GSK356278	720704-34-7	99.43%
T27475	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively...
T19812	Propentofylline	55242-55-2	99.42%
T19812	Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine s...
T5S2059	Glaucine	475-81-0	99.42%
T5S2059	Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 produ...
T25373	EMD57439	148714-88-9	99.38%
T25373	EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).
T21965	MBCQ	150450-53-6	99.38%
T21965	MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.
T36832	PDE4B-IN-2	915082-52-9	99.37%
T36832	PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent an...
T71744	Imazodan	84243-58-3	99.36%
T71744	Imazodan, a small molecule compound with positive inotropic activity, is a selective type III phosphodiesterase inhibitor and can be used to study heart failure....
T10676	Carbodenafil	944241-52-5	99.35%
T10676	Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).
T60608	FPFT-2216	2367619-87-0	99.35%
T60608	FPFT-2216 is a "molecular glue" compound that degrades IKZF6, IKZF1, DE1D, and CK3α. FPFT-2216 has potential antitumor activity and can be used to study immune s...
T14217	AMG 579	1227067-61-9	99.35%
T14217	AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
T10590	Zatolmilast	1606974-33-7	99.31%
T10590	Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
T24656	PQ-10	927691-21-2	99.30%
T24656	PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.
T77603	WAY-313170	314041-83-3	99.3%
T77603	WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.
T33422	MK-0873	500355-52-2	99.29%
T33422	MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.
T1745	Balipodect	1238697-26-1	99.28%
T1745	Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.