PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T15381	Gisadenafil	334826-98-1	99.06%
T15381	Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
T27172	Difamilast	937782-05-3	99.04%
T27172	Difamilast is an inhibitor of phosphodiesterase IV.
T9239	RS-25344	152814-89-6	99.02%
T9239	RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vi...
T22851	ICI 63197	27277-00-5	99.02%
T22851	ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.
T12422	PF-04957325	1305115-80-3	99.02%
T12422	PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimm...
T0264	Zomepirac sodium salt	64092-48-4	99.01%
T0264	Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.
T83974	OPC18750 HCl	145364-90-5	98.92%
T83974	OPC18750 HCl is a potential phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disor...
T22086	HA 155	1229652-22-5	98.92%
T22086	HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.
TN1416	Ayanin	572-32-7	98.9%
TN1416	Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylethe...
T63190	Cudetaxestat	1782070-21-6	98.84%
T63190	Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.
TN3013	4,5-Dimethoxycanthin-6-one	18110-87-7	98.84%
TN3013	4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).4,5-Dimethoxycanthin-6-one was isolated from Picrasma quassio...
T10730	CDC801	192819-27-5	98.81%
T10730	CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.
T78169	Enpp-1-IN-16	2289739-47-3	98.74%
T78169	Enpp-1-IN-16 is an inhibitor targeting ENPP1 with potential anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance in relation to type II diab...
T9773	Thioquinapiperifil dihydrochloride	204077-66-7	98.73%
T9773	Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational ma...
T21865	BC 11-38	686770-80-9	98.72%
T21865	BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).
T13331	WAY127093B racemate	145743-63-1	98.63%
T13331	WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.
T10201	PDE IV-IN-1	225100-12-9	98.57%
T10201	PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease a...
T2855	Icariin	489-32-7	98.49%
T2855	Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T13189	TP-10	898563-00-3	98.48%
T13189	TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
T25376	Ensifentrine	1884461-72-6	98.45%
T25376	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is...