PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T2923	Apremilast	608141-41-9	98.13%
T2923	Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
T3465	Vesnarinone	81840-15-5	98.13%
T3465	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but min...
T16379	Oglemilast	778576-62-8	98.11%
T16379	Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally...
T72031	BI 1015550	1423719-30-5	98.06%
T72031	BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic ...
T7346	Lodenafil	139755-85-4	98%
T7346	Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)
T5956	VP3.15 dihydrobromide	1281681-33-1	98%
T5956	VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1....
T6147	Nortadalafil	171596-36-4	98%
T6147	Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treat...
T5411	PDE10-IN-1	1516896-09-5	98%
T5411	PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.
T7642	Cilostamide	68550-75-4	98%
T7642	Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)
T6445	Cilomilast	153259-65-5	98%
T6445	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.
T9816	Arofylline	136145-07-8	97.98%
T9816	Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.
T1027	Luteolin	491-70-3	97.39%
T1027	Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities...
T21457	Carbazeran	70724-25-3	97.28%
T21457	Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases. Carbazeran shows inotropic and chronotropic effects...
T38759	ONO-8430506	1354805-08-5	97.05%
T38759	ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.
T77641	5-Bromoimidazo[1,2-A]Pyrazine	87597-26-0	97.04%
T77641	5-Bromoimidazo[1,2-a]pyrazine inhibits phosphodiesterase and beta-adrenergic receptors.5-Bromoimidazo[1,2-a]pyrazine shows antibronchospastic activity in vitro.
T8462	Enoximone	77671-31-9	95.52%
T8462	Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.
T5474	D159687	1155877-97-6	95.02%
T5474	D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxioly...
T50062	2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide	473477-26-8	95.00%
T50062	2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.
T39341	FCPR03	1917347-65-9	100.00%
T39341	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. ...
T7888	Enpp-1-IN-1	2289728-58-9	100%
T7888	Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)