PD-1/PD-L1

PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present on the surface of cells. Immune checkpoint inhibitors are emerging as a front-line treatment for several types of cancer.

Cat. No.	Product name	CAS No.	Purity	Chemical Structure
T81461	Pidilizumab	1036730-42-3	98%	Pidilizumab
T81461	Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologic maligna...			Pidilizumab
T81928	Lipustobart	2639481-06-2	98%	Lipustobart
T81928	Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplastic a...			Lipustobart
T82508	Eciskafusp alfa	2649758-52-9	98%
T82508	Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specific s...
T82613	Danburstotug	2307144-65-4	98%	Danburstotug
T82613	Danburstotug (IMC-001), an immunostimulant and antineoplastic [1], is a humanized IgG1-lambda monoclonal antibody targeting CD274 (PDL1, B7 homologue 1, B7H1).			Danburstotug
T82960	ASC-69	1216665-50-7	98%
T82960	ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].
T72668	PD-1/PD-L1-IN-26	2966090-78-6	98%
T72668	PD-1/PD-L1-IN-26 (Compound II-14) is a potent PD-1/PD-L1 inhibitor, demonstrating an IC50 of 0.0380 μM. It enhances the immune microenvironment by facilitating C...
T72680	PD-1/PD-L1-IN-27	2891831-47-1	98%
T72680	PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, exhibiting an IC50 of 134 nM and demonstrating antitumor effects with minimal T cell cytotoxicity. It activ...
T74348	HE-S2	2939851-67-7	98%
T74348	HE-S2, an antibody-drug conjugate, elicits a potent antitumor immune response by inhibiting the PD-1/PD-L1 interaction and stimulating the Toll-like receptor 7/8...
T76080	Human PD-L1 inhibitor V	2815311-61-4	98%
T76080	Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectively ...
T36900	PD-1/PD-L1-IN-NP19	2377916-66-8	98%
T36900	PD-1/PD-L1-IN-NP19 is a PD-1/PD-L1 inhibitor, with an IC50 of 12.5 nM for human PD-1/PD-L1 interaction. PD-1/PD-L1-IN-NP19 could activate the immune microenviron...
T12377	PD-1-IN-17	1673560-66-1	98%
T12377	PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.
T35396	Spartalizumab (anti-PD-1)		98%	Spartalizumab (anti-PD-1)
T35396	Spartalizumab (anti-PD-1) is a useful organic compound for research related to life sciences and the catalog number is T35396.			Spartalizumab (anti-PD-1)
T3655	BMS-1	1675201-83-8	99.86%
T3655	BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1...
T10565	BMS-1001 hydrochloride	2113650-04-5	99.57%
T10565	BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect o...
T67871	LSD1-IN-24	4734-59-2	99.53%
T67871	LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, ...
T9651	PD-1/PD-L1-IN-9	2628506-54-5	99.37%
T9651	PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tum...
T6S0071	Fraxinellone	28808-62-0	99.35%
T6S0071	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
T5697	BMS-1166	1818314-88-3	99.14%
T5697	BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.
T36487	Evixapodlin	2374856-75-2	99.07%
T36487	Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.
T26859	BMS-8	1675201-90-7	99.06%
T26859	BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.