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PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2357 GSK1059615 958852-01-2 98%
GSK1059615
GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.
T3705 GDC0084 1382979-44-3 98%
GDC0084
GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinas...
T2287 PIK-75 hydrochloride 372196-77-5 98%
PIK-75  hydrochloride
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also pote...
T5831 Selective PI3Kδ Inhibitor 1 2088525-31-7 98%
Selective PI3Kδ Inhibitor 1
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).
T2461 PIK-90 677338-12-4 98%
PIK-90
PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
T6330 Linperlisib 1702816-75-8 98%
Linperlisib
Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ
T6773 AZD8186 1627494-13-6 98%
AZD8186
AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).
T7166 GNE-493 1033735-94-2 98%
GNE-493
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for ...
T2P2919 (2S,3R,4S)-4-Hydroxyisoleucine 55399-93-4 98%
(2S,3R,4S)-4-Hydroxyisoleucine
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesit...
T6251 PF-04691502 1013101-36-4 98%
PF-04691502
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
T6319 OSI-027 936890-98-1 98%
OSI-027
OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTO...
T1961 Vistusertib 1009298-59-2 97.94%
Vistusertib
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
T24642 YH-306 1373764-75-0 97.87%
YH-306
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
T4867 Erucic acid 112-86-7 97.85%
Erucic acid
Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Er...
T10804 CHMFL-PI3KD-317 2244992-76-3 97.8%
CHMFL-PI3KD-317
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other clas...
T3986 SF2523 1174428-47-7 97.78%
SF2523
SF2523 is a highly selective and potent inhibitor.
T22377 NIBR-17 944396-88-7 97.67%
NIBR-17
NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.
T64392 PI3K-IN-46 304645-61-2 97.51%
PI3K-IN-46
PI3K-IN-46 is a specific inhibitor of PI3Kγ.
TMA2474 δ-Tocotrienol 25612-59-3 97.38%
δ-Tocotrienol
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
T16750 Rigosertib 592542-59-1 97.33%
Rigosertib
Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer a...
GSK1059615
T2357
GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.
GDC0084
T3705
GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinas...
PIK-75 hydrochloride
T2287
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also pote...
Selective PI3Kδ Inhibitor 1
T5831
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).
PIK-90
T2461
PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
Linperlisib
T6330
Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ
AZD8186
T6773
AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).
GNE-493
T7166
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for ...
(2S,3R,4S)-4-Hydroxyisoleucine
T2P2919
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesit...
PF-04691502
T6251
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
OSI-027
T6319
OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTO...
Vistusertib
T1961
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
YH-306
T24642
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
Erucic acid
T4867
Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Er...
CHMFL-PI3KD-317
T10804
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other clas...
SF2523
T3986
SF2523 is a highly selective and potent inhibitor.
NIBR-17
T22377
NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.
PI3K-IN-46
T64392
PI3K-IN-46 is a specific inhibitor of PI3Kγ.
δ-Tocotrienol
TMA2474
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
Rigosertib
T16750
Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer a...
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