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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0061 Clofibric acid 882-09-7 99.68%
Clofibric acid
Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T1088 Repaglinide 135062-02-1 99.66%
Repaglinide
Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repagli...
T0214L Pioglitazone hydrochloride 112529-15-4 99.66%
Pioglitazone hydrochloride
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic ac...
TN5137 Tetramethylkaempferol 16692-52-7 99.65%
Tetramethylkaempferol
Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with ...
T68000L MK-0533 668455-28-5 99.64%
MK-0533
MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.
T10783 CGS 15435 95853-92-2 99.63%
CGS 15435
CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less select...
T16022 Arhalofenate 24136-23-0 99.62%
Arhalofenate
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
T5764 Alliin 556-27-4 99.62%
Alliin
Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induce...
T3867 Alpinetin 36052-37-6 99.61%
Alpinetin
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to th...
T11747 KD-3010 934760-92-6 99.61%
KD-3010
KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.
T0705 Triflusal 322-79-2 99.61%
Triflusal
Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T60184 TUG-499 1206629-08-4 99.59%
TUG-499
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
T15581 Inolitazone 223132-37-4 99.58%
Inolitazone
Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.
T0214 Pioglitazone 111025-46-8 99.57%
Pioglitazone
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked...
TN3500 Beta-Amyrone 638-97-1 99.55%
beta-Amyrone
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through ...
T4408 Elafibranor 923978-27-2 99.55%
Elafibranor
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC...
T0212 Seratrodast 112665-43-7 99.54%
Seratrodast
Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
T1051 Retinoic acid 302-79-4 99.52%
Retinoic acid
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid in...
T2413 FH535 108409-83-2 99.5%
FH535
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T15049 Daltroban 79094-20-5 99.49%
Daltroban
Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intrac...
Clofibric acid
T0061
Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
Repaglinide
T1088
Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repagli...
Pioglitazone hydrochloride
T0214L
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic ac...
Tetramethylkaempferol
TN5137
Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with ...
MK-0533
T68000L
MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.
CGS 15435
T10783
CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less select...
Arhalofenate
T16022
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
Alliin
T5764
Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induce...
Alpinetin
T3867
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to th...
KD-3010
T11747
KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.
Triflusal
T0705
Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
TUG-499
T60184
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
Inolitazone
T15581
Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.
Pioglitazone
T0214
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked...
beta-Amyrone
TN3500
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through ...
Elafibranor
T4408
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC...
Seratrodast
T0212
Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
Retinoic acid
T1051
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid in...
FH535
T2413
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
Daltroban
T15049
Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intrac...
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TargetMol