PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.

Cat. No.	Product name	CAS No.	Purity
T15945	MA-0204	2095128-17-7	98.83%
T15945	MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mou...
T8699	GFT505	824932-88-9	98.83%
T8699	GFT505 (Elafibranor) (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
T5532	BMS-687453	1000998-59-3	98.79%
T5532	BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in...
T5S1550	Cinnamyl alcohol	104-54-1	98.77%
T5S1550	Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.
T1603	Glipizide	29094-61-9	98.66%
T1603	Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T19094	2,3-Butanediol	513-85-9	98.64%
T19094	2,3-Butanediol is a butanediol derived from the bioconversion of natural resources which has great potential for diverse industries, including chemical, cosmetic...
TN1475	Caulophyllogenin	52936-64-8	98.56%
TN1475	Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammat...
T3362	Eupatilin	22368-21-4	98.53%
T3362	Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
T3710	XMD16-5	1345098-78-3	98.53%
T3710	XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted m...
T2855	Icariin	489-32-7	98.49%
T2855	Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T8184	Fucosterol	17605-67-3	98.39%
T8184	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
T4628	Seladelpar	851528-79-5	98.39%
T4628	Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.
T8486	GW6471	880635-03-0	98.38%
T8486	GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMR...
T2879	Fisetin	528-48-3	98.31%
T2879	Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
TQ0120	CDDO-Im	443104-02-7	98.3%
TQ0120	CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
TN2290	Uvaol	545-46-0	98.27%
TN2290	Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.
T19710	Ciglitazone	74772-77-3	98.23%
T19710	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation o...
TQ0156	GW1929	196808-24-9	98.21%
TQ0156	GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
T2838	Naringenin	480-41-1	98.2%
T2838	Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, car...
TN1055	Licochalcone E	864232-34-8	98.09%
TN1055	Licochalcone E is a potential LXRβ agonist.