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P-gp

P-glycoprotein (P-gp) is a plasma membrane protein which acts as a localized drug transport mechanism, actively exporting drugs out of the cell. The effects of P-gp on the distribution, metabolism and excretion of drugs — including protease inhibitors — in the body is great.

Cat. No.	Product name	CAS No.	Purity
T4085	Paris saponin VII	68124-04-9	99.83%
T4085	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T1010	Verapamil hydrochloride	152-11-4	99.79%
T1010	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T1634	Glibenclamide	10238-21-8	99.77%
T1634	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T0100L	Atazanavir	198904-31-3	99.76%
T0100L	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T0100	Atazanavir sulfate	229975-97-7	99.67%
T0100	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with ...
T11578L	Encequidar mesylate	849675-87-2	99.67%
T11578L	Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
T16339	Norverapamil hydrochloride	67812-42-4	99.63%
T16339	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel...
T77575	P-gb-IN-1	2632874-49-6	99.58%
T77575	P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydr...
T6018	Zosuquidar trihydrochloride	167465-36-3	99.55%
T6018	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.
TN1731	Hernandezine	6681-13-6	99.53%
TN1731	Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
T20656	Verapamil	52-53-9	99.53%
T20656	Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies ab...
T11071	Dofequidar fumarate	153653-30-6	99.43%
T11071	Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the ...
T2657	Elacridar	143664-11-3	99.32%
T2657	Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.
TN1525	Convallatoxin	508-75-8	99.27%
TN1525	Convallatoxin is a natural product
T15713	Larotaxel	156294-36-9	99.22%
T15713	Larotaxel (XRP9881) is a taxane analogue that has anticancer activity, exerts its cytotoxic effects by promoting tubulin assembly and stabilizing microtubules, a...
TN5118	Taxol C	153415-45-3	99.18%
TN5118	Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain.
T2S0223	Isosinensetin	17290-70-9	99.05%
T2S0223	1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.
T8389	Trifluoperazine	117-89-5	99.03%
T8389	Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T3868	Agnuside	11027-63-7	98.98%
T3868	Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, ...
T2799	(20S)-Protopanaxadiol	30636-90-9	98.91%
T2799	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginse...