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P-gp

P-glycoprotein (P-gp) is a plasma membrane protein which acts as a localized drug transport mechanism, actively exporting drugs out of the cell. The effects of P-gp on the distribution, metabolism and excretion of drugs — including protease inhibitors — in the body is great.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2S0271 Voacamine 3371-85-5 98.73%
Voacamine
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein ...
TJS1159 Chrysosplenetin 603-56-5 98.53%
Chrysosplenetin
Chrysosplenetin is a metabolic inhibitor of artemisinin.
T68124 Pafenolol 75949-61-0 98.43%
Pafenolol
Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.
TN1757 Hypophyllanthin 33676-00-5 98.39%
Hypophyllanthin
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
T6287 Tariquidar 206873-63-4 98.34%
Tariquidar
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.
T2S0223 Isosinensetin 17290-70-9 98%
Isosinensetin
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.
T2S2018 7beta-Hydroxylathyrol 34208-98-5 98%
7beta-Hydroxylathyrol
7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp inhibition resulting in cytotoxic properties.
T2S0410 Euphorbia factor L1 76376-43-7 98%
Euphorbia factor L1
1. Euphorbia factor L1 (Euphorbiasteroid) can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 (Euphorbiasteroid) inh...
T3392 Sinapine thiocyanate 7431-77-8 98%
Sinapine thiocyanate
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
T28396 PGP-4008 365565-02-2 97.80%
PGP-4008
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
T13383 Zamicastat 1080028-80-3 97.43%
Zamicastat
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73....
TMA2270 Alisol F 24-acetate 443683-76-9 96.33%
Alisol F 24-acetate
Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX...
T30260 AZD-5672 780750-65-4 95.58%
AZD-5672
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
TN4761 Phellamurin 52589-11-4 93.19%
Phellamurin
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensur...
T0012 Cinchonine 118-10-5 86.31%
Cinchonine
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting ...
T3002 Piperine 94-62-2 100%
Piperine
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
T1222 Trifluoperazine dihydrochloride 440-17-5 100%
Trifluoperazine dihydrochloride
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T0351 Risperidone 106266-06-2 100%
Risperidone
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T4034 Solamargine 20311-51-7
Solamargine
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown t...
T2893 Muscone 541-91-3
Muscone
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
Voacamine
T2S0271
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein ...
Chrysosplenetin
TJS1159
Chrysosplenetin is a metabolic inhibitor of artemisinin.
Pafenolol
T68124
Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.
Hypophyllanthin
TN1757
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
Tariquidar
T6287
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.
Isosinensetin
T2S0223
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.
7beta-Hydroxylathyrol
T2S2018
7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp inhibition resulting in cytotoxic properties.
Euphorbia factor L1
T2S0410
1. Euphorbia factor L1 (Euphorbiasteroid) can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 (Euphorbiasteroid) inh...
Sinapine thiocyanate
T3392
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
PGP-4008
T28396
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
Zamicastat
T13383
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73....
Alisol F 24-acetate
TMA2270
Alisol F 24-acetate is a natural product isolated from Alisma plantago-aquatica Linn[1]. Alisol F 24 Acetate enhances chemosensitivity and apoptosis of MCF-7/DOX...
AZD-5672
T30260
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
Phellamurin
TN4761
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensur...
Cinchonine
T0012
Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting ...
Piperine
T3002
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Trifluoperazine dihydrochloride
T1222
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
Risperidone
T0351
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Solamargine
T4034
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown t...
Muscone
T2893
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
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TargetMol