| T0038 |
Doxapram hydrochloride monohydrate |
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| T0075 |
Nicorandil |
Nicorandil(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. First...
|
| T0126 |
Diazoxide |
Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it l...
|
| T0127 |
Glimepiride |
Glimepiride is a long-acting, third-generation sulfonylurea with hypoglycemic activity. |
| T0161 |
Pantoprazole Sodium Hydrate |
Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease...
|
| T0266 |
Quinidine hydrochloride |
Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and dec...
|
| T0342 |
Carvedilol phosphate |
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
|
| T0344 |
Miconazole |
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. |
| T0365 |
Thioridazine hydrochloride |
Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity. |
| T0371 |
Gliquidone |
Gliquidone is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater bindin...
|
| T0386 |
Ropivacaine hydrochloride |
Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. |
| T0447 |
Carvedilol |
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
|
| T0451 |
Minoxidil |
Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects. |
| T0483 |
Sotalol hydrochloride |
Sotalol Hydrochloride is the hydrochloride salt form of sotalol, an ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties. |
| T0690 |
Quinine |
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cra...
|
| T0700 |
Ursodeoxycholic acid |
Ursodeoxycholic acid can be used to dissolve gallstones and reduce cholesterol absorption. |
| T0791 |
Reserpine |
Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resu...
|
| T0816 |
Acetohexamide |
Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inw...
|
| T0847 |
Chenodeoxycholic acid |
Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorb...
|
| T0866 |
Propafenone |
Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythm...
|
| T0954 |
Anestan |
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
|
| T0974 |
Albamycinsodium |
Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
|
| T1050 |
Prazosin hydrochloride |
Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complet...
|
| T1054 |
Tolbutamide |
Tolbutamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. |
| T1073 |
Dronedarone hydrochloride |
Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation. |
| T1088 |
Repaglinide |
Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
|
| T1138 |
Taurocholic acid sodium salt hydrate |
Taurocholic acid sodium salt hydrate is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous ...
|
| T1146 |
Nifedipine |
Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
|
| T11753 |
Keto Ziprasidone |
Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist. Keto Ziprasidone is an impurity of Ziprasidone. |
| T1204 |
Bendroflumethiazide |
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, ede...
|
| T1206 |
Amsacrine |
Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specific...
|
| T12504 |
(+)-KCC2 blocker 1 |
(+)-KCC2 blocker 1 is a selective blocker of K+-Cl- cotransporter KCC2(IC50 of 0.4 μM). |
| T1260 |
Sodium cromoglycate |
Cromolyn sodium is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. |
| T1266 |
Terfenadine |
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistami...
|
| T1278 |
Astemizole |
Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors...
|
| T1291 |
Cisapride |
Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal p...
|
| T1320 |
Disopyramide |
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
|
| T13316 |
VU0134992 hydrochloride |
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 µM). |
| T13320 |
VU591 hydrochloride |
VU591 hydrochloride is a selective inhibitor of renal outer medullary potassium channel (ROMK or Kir1.1) (IC50：0.24 μM). |
| T13320L |
VU591 |
VU591 is a potent and selective renal outer medullary potassium channel inhibitor (IC50: 0.24 μM). |
| T1333 |
Tolazamide |
Tolazamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. |
| T1334 |
Hydroquinidine |
Dihydroquinidine is an organic compound, used as an antiarrhythmic agent. |
| T14040 |
4-Hydroxytolbutamide |
4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium ch...
|
| T14189 |
Almokalant |
Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it inhibits a specific component (Ikr) of the time-dependent delayed rec...
|
| T1449 |
Hydrochlorothiazide |
Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis. |
| T1453 |
Phenformin hydrochloride |
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. |
| T14666 |
BL-1249 |
BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) t...
|
| T1496 |
Amiodarone hydrochloride |
Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting PO...
|
| T1498 |
Indapamide |
Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. |
| T14982 |
Clofilium tosylate |
Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspas...
|
| T14984 |
CLP257 |
CLP257 is a selective activator of K+-Cl− cotransporter KCC2 (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 all...
|
| T1527 |
Gliclazide |
Gliclazide, an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to ...
|
| T1530 |
Mitiglinide calcium |
Mitiglinide is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) chann...
|
| T15545 |
ICA-27243 |
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27...
|
| T15555 |
IK1 inhibitor PA-6 |
IK1 inhibitor PA-6 (PA-6) improves KIR2.1 protein expression and causes intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat ...
|
| T15758 |
Linopirdine |
Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine...
|
| T16110 |
ML418 |
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1. |
| T16124 |
MMP13-IN-3 |
MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment...
|
| T16285 |
Neosolaniol |
Neosolaniol evokes a robust anorectic response. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp. |
| T1634 |
Glyburide |
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. |
| T1650 |
Chlorzoxazone |
Chlorzoxazone is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation. |
| T1674 |
Nateglinide |
Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
|
| T17243 |
VU0463271 |
VU0463271 is an effective antagonist of KCC2 (IC50: 61 nM). |
| T17262 |
XE 991 dihydrochloride |
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, an...
|
| T1752 |
NS6180 |
NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation. |
| T2546 |
Pimozide |
Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic re...
|
| T2S1635 |
3-Isomangostin |
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has ...
|
| T3102 |
NS 1619 |
NS1619 have cardio-protective effects after ischemia-reperfusion injury. |
| T3332 |
Isosteviol |
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
|
| T3528 |
Senicapoc |
Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human ...
|
| T3557 |
GAL-021 |
GAL-021 an intravenous BKCa-channel blocker. |
| T3581 |
KS176 |
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or M...
|
| T3959 |
ICA069673 |
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM). |
| T3S0870 |
Paederosidic acid methyl ester |
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels. |
| T4030 |
ML213 |
ML213 is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. |
| T4224 |
ML335 |
ML335 is a selective activator of both TREK-1 and TREK-2. |
| T4316 |
ML365 |
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3). |
| T4612 |
NS309 |
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for S...
|
| T5180 |
SKA-31 |
SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). |
| T5183 |
AUT1 |
AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a). |
| T5336 |
Zacopride hydrochloride |
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist. |
| T5444 |
CLP-290 |
CLP290 is an activator of the neuron-specific K+-Cl- cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric...
|
| T5585 |
AM-92016 hydrochloride |
AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the ...
|
| T6476 |
Dofetilide |
Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid compon...
|
| T6504 |
Flupirtine maleate |
Flupirtine maleate， a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal ...
|
| T6592 |
ML133 HCl |
ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for...
|
| T6631 |
Quinine HCl Dihydrate |
Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria. |
| T6978 |
Almitrine dimesylate |
Almitrine dimesylate inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cells,used in the treatment of hypoxemic chronic lung dise...
|
| T7056 |
Dronedarone |
Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. |
| T7190 |
Actein |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblas...
|
| T7195 |
GSK369796 Dihydrochloride |
GSK369796 Dihydrochloride,is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(...
|
| T7198 |
E-4031 |
E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM) |
| T7505 |
Azimilide Dihydrochloride |
Azimilide Dihydrochloride, a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delaye...
|
| T7512 |
BMS-191011 |
BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models |
| T7612 |
ICA 110381 |
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy |
| T7653 |
JNJ 303 |
JNJ 303 is a potent blocker of IKs (IC50 : 64 nM). |
| T7775 |
A2764 dihydrochloride |
A2764 dihydrochloride is a highly selective inhibitor of TRESK. |
| T7899 |
VU0810464 |
VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. |
| T8040 |
Cholesterol myristate |
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic ac...
|
| T8182 |
Guan-fu base A |
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current. |
| T8361 |
Tetraethylammonium bromide |
Tetraethylammonium bromide can selectively block potassium channels. |
| T8372 |
VU 0134992 |
VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 µM |
| T8700 |
TKIM |
TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1. |
| TMA0763 |
Methyl 3,4,5-trimethoxycinnamate |
Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel. |
| TMA0805 |
Lupanine |
Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lup...
|
| TN1032 |
Geissoschizine methyl ether |
Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan |
| TN1367 |
Alismol |
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for...
|
| TN1588 |
Dihydroisotanshinone I |
Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
|
| TN1757 |
Hypophyllanthin |
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. |
| TN1874 |
Liriodendrin |
Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
|
| TN2215 |
Sodium taurochenodeoxycholate |
Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of α²-cells and enhance cytosolic Ca(2+) co...
|
| TN2239 |
Strictosamide |
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain. |
| TN2306 |
Wilfordine |
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect. |
| TN2918 |
3-Acetoxy-8(17),13E-labdadien-15-oic acid |
ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane inv...
|
| TN3042 |
4-Hydroxycinnamamide |
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. |
| TN3319 |
9-Hydroxycanthin-6-one |
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as...
|
| TN3379 |
Allocryptopine |
Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyt...
|
| TN3460 |
Asebogenin |
Asebogenin has anti-bacterial activity, it shows inhibitory activity against S. aureus and methicillin-resistant S. aureus (IC50 of 10 and 4.5 micrograms/ml, re...
|
| TN3636 |
Chlorahololide C |
Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current wit...
|
| TN3831 |
Denudatin B |
Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
|
| TN3910 |
Ecdysone |
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
|
| TN4303 |
Isokaempferide |
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
|
| TN4322 |
Isopulegol |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly r...
|
| TN4638 |
Neolinine |
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity. |
| TN4697 |
Odoroside H |
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase. |
| TN5060 |
Stauntosaponin A |
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively. |
| TN5141 |
Thevetin B |
Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors. |
| TQ0139 |
VU 0240551 |
VU 0240551 is a neuronal K-Cl cotransporter KCC2 inhibitor (IC50: 560 nM for K+ uptake assay in KCC2-overexpressing cells). |
| TQ0150 |
Levcromakalim |
Levcromakalim is an activator of the ATP-sensitive K+ channel. |
| TQ0179 |
PAP-1 |
PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM). |
| TQ0307 |
Vernakalant |
Vernakalant (RSD-1235) is a mixed ion channel blocker. |
