Potassium Channel

Potassium Channels. K+ channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, and thus generate electrical signals in cells. Voltage-gated K+ channels (Kv channels), present in all animal cells, open and close upon changes in the transmembrane potential.

Cat No.	product name
T0038	Doxapram hydrochloride monohydrate	Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
T0075	Nicorandil	Nicorandil(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. First...
T0126	Diazoxide	Diazoxide is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it l...
T0127	Glimepiride	Glimepiride is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
T0161	Pantoprazole Sodium Hydrate	Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease...
T0266	Quinidine hydrochloride	Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and dec...
T0342	Carvedilol phosphate	Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
T0344	Miconazole	Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion.
T0365	Thioridazine hydrochloride	Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T0371	Gliquidone	Gliquidone is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater bindin...
T0447	Carvedilol	Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
T0451	Minoxidil	Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
T0483	Sotalol hydrochloride	Sotalol Hydrochloride is the hydrochloride salt form of sotalol, an ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties.
T0690	Quinine	Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cra...
T0700	Ursodeoxycholic acid	Ursodeoxycholic acid can be used to dissolve gallstones and reduce cholesterol absorption.
T0791	Reserpine	Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resu...
T0816	Acetohexamide	Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inw...
T0847	Chenodeoxycholic acid	Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorb...
T0866	Propafenone	Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythm...
T0954	Anestan	Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be ade...
T0974	Albamycinsodium	Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces nive...
T1050	Prazosin hydrochloride	Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not complet...
T1054	Tolbutamide	Tolbutamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
T1073	Dronedarone hydrochloride	Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T1088	Repaglinide	Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been...
T1138	Taurocholic acid sodium salt hydrate	Taurocholic acid sodium salt hydrate is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous ...
T1146	Nifedipine	Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
T1204	Bendroflumethiazide	A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, ede...
T1206	Amsacrine	Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specific...
T1260	Sodium cromoglycate	Cromolyn sodium is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
T1266	Terfenadine	Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistami...
T1278	Astemizole	Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors...
T1291	Cisapride	Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal p...
T1320	Disopyramide	A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
T1333	Tolazamide	Tolazamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
T1334	Hydroquinidine	Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
T1449	Hydrochlorothiazide	Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
T1453	Phenformin hydrochloride	Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T1496	Amiodarone hydrochloride	Amiodarone hydrochloride is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting PO...
T1498	Indapamide	Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
T1527	Gliclazide	Gliclazide, an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to ...
T1530	Mitiglinide calcium	Mitiglinide is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) chann...
T1634	Glyburide	Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1650	Chlorzoxazone	Chlorzoxazone is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
T1674	Nateglinide	Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 dia...
T1752	NS6180	NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.
T2546	Pimozide	Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic re...
T3102	NS 1619	NS1619 have cardio-protective effects after ischemia-reperfusion injury.
T3332	Isosteviol	Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
T3528	Senicapoc	Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human ...