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Cat No. | Product Name | Synonyms | Targets |
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T3036 | Dydrogesterone | Progesterone Receptor | |
Dydrogesterone is a potent progestogen which can be used in progesterone deficiency studies. | |||
T13703 | Gestonorone Capronate | Prostaglandin Receptor | |
Gestonorone Capronate is a progesterone used to treat benign prostatic hyperplasia and endometrial cancer. | |||
T7537 | Norgestimate | Progesterone Receptor | |
Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive. | |||
T1514 | Norethindrone | Norethisterone | Estrogen/progestogen Receptor , Progesterone Receptor |
Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties... | |||
T28362 | PF-02413873 | PF02413873 | Progesterone Receptor |
PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis. | |||
T8395 | Nomegestrol acetate | Others , Progesterone Receptor | |
Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor | |||
T1596 | Chlormadinone acetate | Gestafortin | Progesterone Receptor , Androgen Receptor |
Chlormadinone acetate (Gestafortin) is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive. | |||
T1541 | Drospirenone | ZK 3059,Dihydrospirorenone | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , COX |
Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. | |||
T0996 | Ethynodiol diacetate | Ethynodiol acetate,8080 CB | Estrogen/progestogen Receptor , Progesterone Receptor |
Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. | |||
T6819 | Desogestrel | Org-2969,Desogen,Desogestrelum,Cerazette | Estrogen/progestogen Receptor , Progesterone Receptor |
Desogestrel (Cerazette) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. | |||
T6713 | Ulipristal | Estrogen/progestogen Receptor , Progesterone Receptor | |
Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure. | |||
T5317 | Cridanimod | CMA,XBIO-101,10-carboxymethyl-9-acridanone | Progesterone Receptor , STING , IFNAR |
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. | |||
T2577 | Dienogest | STS 557 | Apoptosis , Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy |
Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therap... | |||
T1490 | Gestodene | SHB 331,WL 70 | Estrogen/progestogen Receptor , Progesterone Receptor |
Gestodene (WL 70) is a progestogen hormonal contraceptive. | |||
T5174 | Nestoron | ST-1435,Segesterone Acetate,Nestorone,Elcometrine | Estrogen/progestogen Receptor , Progesterone Receptor |
Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM). | |||
T0870 | Altrenogest | R2267,RU2267,Allyltrenbolone,A35957 | Estrogen/progestogen Receptor , Progesterone Receptor |
Altrenogest (Allyltrenbolone)(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone. | |||
T14975 | CJ-42794 | CJ-042794 | Others |
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... | |||
T2527 | Ulipristal acetate | Ulipristal,CDB-2914 | Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy |
Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereb... | |||
T2567 | Etonogestrel | 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite |
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives. | |||
T1102 | Mifepristone | C-1073,RU486,RU 38486 | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , NO Synthase , Autophagy |
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist. | |||
T2231 | Estradiol dipropionate | 17-Beta-Estradiol-3,17-Dipropionate | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor |
Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol. | |||
T20720 | Norethisterone enanthate | NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,NSC-9564 | Estrogen/progestogen Receptor |
Norethisterone enanthate (NSC-9564) is a long-acting parenteral progestogen with antigonadotropic effects. | |||
T60056 | Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl- | Progesterone Receptor | |
Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl- is a progesterone receptor antagonist with antiprogestin effects. | |||
T35054 | Vilaprisan | BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670 | Progesterone Receptor |
Vilaprisan (BAY 1002670) is a novel orally available and selective progesterone receptor modulator (SPRM) with antiproliferative activity against uterine fibroids (UF) and can be used for the study of uterine fibroids. | |||
TP1862L | [Sar9] Substance P acetate(77128-75-7 free base) | Neurokinin receptor | |
[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP. | |||
T21395 | Finerenone | BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 | Glucocorticoid Receptor |
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862... | |||
T16502 | PF-3882845 | Others | |
PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for ... | |||
T17291 | ZK 216348 | (+)-ZK 216348 | Others |
ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an an... | |||
T28995 | Tosagestin | Org 30659,Org30659,Org-30659 | |
Tosagestin is a progesterone receptor agonist. | |||
T28263 | Org-31710 | Org 31710,Org31710 | |
Org-31710 is a progesterone receptor antagonist potentially for contraception. | |||
T31082 | CP-8668 | UNII-5371O2R79D,CP 8668 | |
CP-8668 is an orally active nonsteroidal progesterone receptor modulator with tetrahydrobenzoindolone skeleton. | |||
T14332 | Asoprisnil | J867 | Others |
Asoprisnil is a selective modulator of progesterone receptor. | |||
T29224 | ZK112993 | ZK-112993,ZK 112993 | |
ZK112993 is an antagonist of human progesterone receptor. | |||
T34798 | Telapristone | metabolite of telapristone acetate (CDB-4124) | |
Telapristone, is the active metabolite of telapristone acetate (also known as CDB-4124). Telapristone is a selective progesterone receptor modulator (SPRM) being studied for the treatment of certain progesterone-sensitiv... | |||
T28264 | Org-33628 | ||
Org-33628, a progesterone receptor antagonist, is used potentially for female contraception. | |||
T27108 | Cymipristone | ZXH951,ZXH 951,ZXH-951 | |
Cymipristone, a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy. | |||
T27662 | JNJ-1250132 | JNJ 1250132,JNJ1250132 | |
JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro. | |||
T25304 | Demegestone | R-2453,Lutionex,R 2453,RU 2453,R2453 | |
Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat lutea... | |||
T16396 | OP-3633 | Others | |
OP-3633 is an effective and selective steroidal glucocorticoid receptor (GR) antagonist (IC50: 29 nM). OP-3633 shows low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism. It also has an inhibition... | |||
T16985 | Tanaproget | NSP-989 | Others |
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM), | |||
T28237 | Onapristone | IVV-1001,ZK 98299,IVV 1001,ZK98299,ZK-98299,IVV1001 | |
Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding. | |||
T68473 | WAY-255348 | ||
WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-... | |||
T37319 | 5β-Dihydroprogesterone | ||
5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when u... | |||
T19697 | Norgestomet | SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009 | |
Norgestomet is a steroidal progestin of the 19-norprogesterone group used in veterinary medicine to control estrus and ovulation in cattle. In addition to the progesterone receptor, norgestomet possesses a weak (micromol... | |||
T69895 | Lonaprisan | ||
Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; b... | |||
T69717 | Dimethandrolone | ||
Dimethandrolone (DMA), also known by its developmental code name CDB-1321, is an experimental androgen/anabolic steroid (AAS) and progestogen medication which is under investigation for potential clinical use. Dimethandr... | |||
T26669 | Asoprisnil ecamate | J956,J-956,J 956 | |
Asoprisnil ecamate is a selective progesterone receptor modulator. Asoprisnil inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cell... | |||
T28280 | Oxendolone | Roxenone,Prostetin | |
Oxendolone is a steroidal progestin and antiandrogen. Oxendolone binds to the progesterone receptor (Ki = 20 nM) and androgen receptor (AR) (Ki = 320 nM) and acts as a weak but clinically relevant inhibitor of 5α-reducta... | |||
T19684 | Pregnanolone | SKF 6455,Kabi-2213,Kabi 2213,Eltanolone,Kabi2213,SKF6455 | |
Pregnanolone is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA rec... | |||
T39853 | ARD-61 | ||
ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apo... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0478 | Progesterone | Pregn-4-ene-3,20-dione | Estrogen/progestogen Receptor , Progesterone Receptor , Opioid Receptor , Endogenous Metabolite |
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is require... | |||
T1263 | Levonorgestrel | D-Norgestrel | Others , Estrogen/progestogen Receptor , Progesterone Receptor |
Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. | |||
T5040 | Medroxyprogesterone | Estrogen/progestogen Receptor , Progesterone Receptor | |
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. | |||
T1261 | Medroxyprogesterone Acetate | Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate) | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , Endogenous Metabolite |
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been... | |||
T1429 | 17α-Hydroxyprogesterone | Hydroxyprogesterone,17-OHP,17-Hydroxyprogesterone | Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite |
17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to th... | |||
T1284 | Megestrol acetate | SC10363,BDH1298 | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , HIV Protease , Autophagy |
Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment ... | |||
T7974 | Lynestrenol | Progesterone Receptor | |
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist | |||
T7931 | 16a,17a-Epoxy-4-Pregnen-3,20-Dione | Others | |
16a,17a-Epoxy-4-Pregnen-3,20-Dione is a synthetic progestin, a metabolite of the luteinizing hormone hormone, which acts by binding to the luteinizing hormone receptor. It has been used to study the effects of progestero... |
Cat No. | Product Name | Species | Expression System |
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TMPK-00717 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag) | Human | HEK293 |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ... | |||
TMPK-00591 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His) | Mouse | HEK293 |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ... | |||
TMPK-00716 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244) | Human | HEK293 |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ... | |||
TMPH-01793 | NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentia... | |||
TMPY-01383 | PRMT6 Protein, Human, Recombinant (His & Flag) | Human | HEK293 |
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex... | |||
TMPH-00279 | Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His) | Bovine | Yeast |
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-... | |||
TMPH-00278 | Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His) | Bovine | E. coli |
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-... | |||
TMPH-00851 | HSD3B1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the... | |||
TMPY-02138 | Uteroglobin Protein, Human, Recombinant (His) | Human | HEK293 |
Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of sma... | |||
TMPY-02328 | Uteroglobin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of sma... |
Cat No. | Product Name | ||
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L2191 | Anti-Breast Cancer Compound Library | 1965 compounds | |
A unique collection of 1965 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; |